Cited by 348Insect Resistance and GeneticsInsect-Plant Interactions and ControlTransgenic Plants and Applications

Next-generation insect-resistant plants: RNAi-mediated crop protection

Open access
Zhang, Jiang, Khan, Sher Afzal, Heckel, David G., Bock, Ralph·2017·Trends in Biotechnology

Abstract

Plant-mediated RNA interference (RNAi) shows great potential in crop protection. It relies on plants stably expressing double-stranded RNAs (dsRNAs) that target essential genes in pest insects. Practical application of this strategy is challenging because producing sufficient amounts of stable dsRNA in plants has proven to be difficult to achieve with conventional transgenesis. In addition, many insects do not respond to exogenously applied dsRNAs, either degrading them or failing to import them into the cytoplasm. We summarize recent progress in RNAi-mediated insect pest control and discuss factors determining its efficacy. Expressing dsRNA in chloroplasts overcomes many of the difficulties previously encountered. We also highlight remaining challenges and discuss the environmental and biosafety issues involved in the use of this technology in agriculture.

Integrity signals

Registry

Crossref · 10.1016/j.tibtech.2017.04.009

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Plants can be developed to produce dsRNA that silences an essential gene in the target species after ingestion.

    “Another promising new development is the use of RNA interference (RNAi) to control arthropod pests by developing plants to produce double-stranded RNA (dsRNA) that silences an essential gene in the target species after ingestion (Burand and Hunter, 2013;Zhang et al., 2017).”

    From Genetically engineered crops help support conservation biological control (2019) · cites this paper as Zhang et al., 2017

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zhang, J., Khan, S. A., Heckel, D. G., & Bock, R.
Affiliations
  • Max Planck Institute of Molecular Plant Physiology (DE)
  • Max Planck Institute for Chemical Ecology (DE)
Corresponding author
  • Heckel, David G.
  • Bock, Ralph
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2017-09
Volume
35
Issue
9
Pages
871-882
ISSN
0167-7799 (ISSN-L)
OpenAlex
W2736891943
Cited by
348
References
53
Citations by year
2026: 24 · 2025: 41 · 2024: 42 · 2023: 31 · 2022: 52 · 2021: 50 · 2020: 37 · 2019: 39 · 2018: 30 · 2017: 2
FWCI
2.76
Type
journal article
Language
en
Open access
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders
  • European Research Council (ERC) (669982)
  • National Natural Science Foundation of China (31572071)
  • National Key Research and Development Program of China (SQ2017YFNC030122)
  • Science and Technology Department of Hubei Province of China (2016CFA052)
  • Recruitment Program of Global Experts
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
Keywords
RNA interference, insect pest control, double-stranded RNA, chloroplast transformation, genetically modified crops, insect resistance, dsRNA stability, biosafety, environmental risk
MeSH terms
Animals, Chloroplasts, Insecta, Pest Control, Biological, RNA, Double-Stranded, Crops, Agricultural, RNA, Plant, Plants, Genetically Modified, RNA Interference

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review