A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Pleiotropy, natural selection, and the evolution of senescence.

Williams, G. C. (1957) · Evolution · doi:10.1111/j.1558-5646.1957.tb02911.x · Cited by 4,279 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Cytosine methylation and the ecology of intragenomic parasites

Yoder, J. A., Walsh, C. P., & Bestor, T. H. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01181-5 · Cited by 1,941 · see citing works

Mobile Elements: Drivers of Genome Evolution

Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922 · see citing works

A germline-specific class of small RNAs binds mammalian Piwi proteins

Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762 · see citing works

The origin and behavior of mutable loci in maize

McClintock, B. (1950) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.36.6.344 · Cited by 1,752 · see citing works

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencingPreprint

Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., Livingston, D. M., & Rajewsky, K. (2005) · Genes & Development · doi:10.1101/gad.1248505 · Cited by 1,256 · see citing works

Role of transposable elements in heterochromatin and epigenetic control

Lippman, Z. B., Gendrel, A.-V., Black, M. A., Vaughn, M. W., Dedhia, N., McCombie, W. R., Lavine, K., Mittal, V., May, B., Kasschau, K. D., et al. (2004) · Nature · doi:10.1038/nature02651 · Cited by 1,231 · see citing works

Lamin A-Dependent Nuclear Defects in Human Aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works

Molecular basis of base substitution hotspots in Escherichia coli

Coulondre, C., Miller, J. H., Farabaugh, P. J., & Gilbert, W. (1978) · Nature · doi:10.1038/274775a0 · Cited by 1,193 · see citing works

Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition

Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139 · see citing works

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096 · see citing works

Hot L1s account for the bulk of retrotransposition in the human population

Brouha, B., Schustak, J., Badge, R. M., Lutz-Prigge, S., Farley, A. H., Moran, J. V., & Kazazian, H. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831042100 · Cited by 1,073 · see citing works

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man

Kazazian, H. H., Wong, C., Youssoufian, H., Scott, A. F., Phillips, D. G., & Antonarakis, S. E. (1988) · Nature · doi:10.1038/332164a0 · Cited by 929 · see citing works

Alu Repeats and Human Disease

Deininger, P. L., & Batzer, M. A. (1999) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1999.2864 · Cited by 911 · see citing works

Biology of Mammalian L1 Retrotransposons

Ostertag, E. M., & Kazazian, H. H. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091032 · Cited by 764 · see citing works

Argonaute Proteins: Mediators of RNA Silencing

Peters, L., & Meister, G. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.001 · Cited by 695 · see citing works

An endogenous small interfering RNA pathway in Drosophila

Czech, B., Malone, C. D., Zhou, R., Stark, A., Schlingeheyde, C., Dus, M., Perrimon, N., Kellis, M., Wohlschlegel, J. A., Sachidanandam, R., et al. (2008) · Nature · doi:10.1038/nature07007 · Cited by 692 · see citing works

Origin of a substantial fraction of human regulatory sequences from transposable elements

Jordan, I. K., Rogozin, I. B., Glazko, G. V., & Koonin, E. V. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(02)00006-9 · Cited by 577 · see citing works

The Argonaute protein family

Höck, J., & Meister, G. (2008) · Genome biology · doi:10.1186/gb-2008-9-2-210 · Cited by 564 · see citing works

The impact of L1 retrotransposons on the human genome

Kazazian, H. H., & Moran, J. V. (1998) · Nature Genetics · doi:10.1038/ng0598-19 · Cited by 520 · see citing works

The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks

Gasior, S. L., Wakeman, T. P., Xu, B., & Deininger, P. L. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.01.089 · Cited by 519 · see citing works

DNA repair is limiting for haematopoietic stem cells during ageing

Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518 · see citing works

Human L1 Retrotransposition Is Associated with Genetic Instability In Vivo

Symer, D. E., Connelly, C. J., Szak, S. T., Caputo, E. M., Cost, G. J., Parmigiani, G., & Boeke, J. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00839-5 · Cited by 479 · see citing works

Genomic Deletions Created upon LINE-1 Retrotransposition

Gilbert, N., Lutz-Prigge, S., & Moran, J. V. (2002) · Cell · doi:10.1016/s0092-8674(02)00828-0 · Cited by 474 · see citing works

Timescales of Genetic and Epigenetic Inheritance

Rando, O. J., & Verstrepen, K. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.023 · Cited by 461 · see citing works

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

Kawamura, Y., Saito, K., Taishin Kin, A., Ono, Y., Asai, K., Sunohara, T., Okada, T. N., Siomi, M. C., & Siomi, H. (2008) · Nature · doi:10.1038/nature06938 · Cited by 450 · see citing works

Impact of aging on DNA methylation

Richardson, B. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00010-2 · Cited by 420 · see citing works

Millions of Years of Evolution Preserved: A Comprehensive Catalog of the Processed Pseudogenes in the Human GenomePreprint

Zhang, Z. (2003) · Genome Research · doi:10.1101/gr.1429003 · Cited by 420 · see citing works

Diversity of microRNAs in human and chimpanzee brain

Berezikov, E., Thuemmler, F., van Laake, L. W., Kondova, I., Bontrop, R., Cuppen, E., & Plasterk, R. H. A. (2006) · Nature Genetics · doi:10.1038/ng1914 · Cited by 416 · see citing works

L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells

Yang, N., & Kazazian, H. H. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1141 · Cited by 398 · see citing works

Mammalian RetroelementsPreprint

Deininger, P. L., & Batzer, M. A. (2002) · Genome Research · doi:10.1101/gr.282402 · Cited by 355 · see citing works

APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition

Muckenfuß, H., Hamdorf, M., Held, U., Perković, M., Löwer, J., Cichutek, K., Flory, E., Schumann, G. G., & Münk, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601716200 · Cited by 353 · see citing works

Cellular senescence and organismal aging

Jeyapalan, J. C., & Sedivy, J. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.001 · Cited by 347 · see citing works

Mammalian non-LTR retrotransposons: For better or worse, in sickness and in healthPreprint

Belancio, V. P., Hedges, D. J., & Deininger, P. L. (2008) · Genome Research · doi:10.1101/gr.5558208 · Cited by 317 · see citing works

L1 (LINE-1) Retrotransposon Evolution and Amplification in Recent Human History

Boissinot, S., Chevret, P., & Furano, A. V. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026372 · Cited by 312 · see citing works

Creation of genomic methylation patterns

Bestor, T. H., & Tycko, B. (1996) · Nature Genetics · doi:10.1038/ng0496-363 · Cited by 310 · see citing works

Caloric restriction in humans

Holloszy, J. O., & Fontana, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.009 · Cited by 304 · see citing works

Multiple Fates of L1 Retrotransposition Intermediates in Cultured Human Cells

Gilbert, N., Lutz, S., Morrish, T. A., & Moran, J. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7780-7795.2005 · Cited by 283 · see citing works

RNA truncation by premature polyadenylation attenuates human mobile element activity

Perepelitsa-Belancio, V., & Deininger, P. L. (2003) · Nature Genetics · doi:10.1038/ng1269 · Cited by 265 · see citing works

Mighty Piwis Defend the Germline against Genome Intruders

O’Donnell, K. A., & Boeke, J. D. (2007) · Cell · doi:10.1016/j.cell.2007.03.028 · Cited by 261 · see citing works

Developmental and cell type specificity of LINE-1 expression in mouse testis: implications for transposition.

Branciforte, D., & Martin, S. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2584 · Cited by 231 · see citing works

Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells

Belgnaoui, S. M., Gosden, R. G., Semmes, O. J., & Haoudi, A. (2006) · Cancer Cell International · doi:10.1186/1475-2867-6-13 · Cited by 219 · see citing works

Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma. Comparison with chronic liver diseases

Shirai, Y., Kawata, S., Tamura, S., Ito, N., Tsushima, H., Takaishi, K., Kiso, S., & Matsuzawa, Y. (1994) · Cancer · doi:10.1002/1097-0142(19940501)73:9 · Cited by 210 · see citing works

Identification of critical CpG sites for repression of L1 transcription by DNA methylation

Hata, K., & Sakaki, Y. (1997) · Gene · doi:10.1016/s0378-1119(96)00856-6 · Cited by 208 · see citing works

L1 retrotransposition can occur early in human embryonic development

van den Hurk, J. A. J. M., Meij, I. C., del Carmen Seleme, M., Kano, H., Nikopoulos, K., Hoefsloot, L. H., Sistermans, E. A., de Wijs, I. J., Mukhopadhyay, A., Plomp, A. S., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm108 · Cited by 193 · see citing works

Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription

Yu, F. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.21.4493 · Cited by 190 · see citing works

Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates

Ohshima, K., Hattori, M., Yada, T., Gojobori, T., Sakaki, Y., & Okada, N. (2003) · Genome biology · doi:10.1186/gb-2003-4-11-r74 · Cited by 184 · see citing works

An estimated frequency of endogenous insertional mutations in humans

Kazazian, H. H. (1999) · Nature Genetics · doi:10.1038/9638 · Cited by 179 · see citing works

Cell Type-specific Expression of LINE-1 Open Reading Frames 1 and 2 in Fetal and Adult Human Tissues

Ergün, S., Buschmann, C., Heukeshoven, J., Dammann, K., Schnieders, F., Lauke, H., Chalajour, F., Kilic, N., Strätling, W. H., & Schumann, G. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312985200 · Cited by 175 · see citing works

Nature and Structure of Human Genes that Generate RetropseudogenesPreprint

Gonçalves, I., Duret, L., & Mouchiroud, D. (2000) · Genome Research · doi:10.1101/gr.10.5.672 · Cited by 169 · see citing works

The Genetics of Human Longevity

Capri, M., Salvioli, S., Sevini, F., Valensin, S., Celani, L., Monti, D., Pawelec, G., Benedictis, G. D., Gonos, E. S., & Franceschi, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.033 · Cited by 153 · see citing works

L1 mobile element expression causes multiple types of toxicity

Wallace, N. A., Belancio, V. P., & Deininger, P. L. (2008) · Gene · doi:10.1016/j.gene.2008.04.013 · Cited by 150 · see citing works

Rapid amplification of a retrotransposon subfamily is evolving the mouse genome

DeBerardinis, R. J., Goodier, J. L., Ostertag, E. M., & Kazazian, H. H. (1998) · Nature Genetics · doi:10.1038/3104 · Cited by 149 · see citing works

RNA editing, DNA recoding and the evolution of human cognition

Mattick, J. S., & Mehler, M. F. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.003 · Cited by 149 · see citing works

L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas

Menéndez, L., Benigno, B., & McDonald, J. (2004) · Molecular Cancer · doi:10.1186/1476-4598-3-12 · Cited by 144 · see citing works

Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay

Farkash, E. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj522 · Cited by 141 · see citing works

Duplication of the gamma-globin gene mediated by L1 long interspersed repetitive elements in an early ancestor of simian primates.

Fitch, D. H. A., Bailey, W. J., Tagle, D. A., Goodman, M., Sieu, L. C., & Slightom, J. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7396 · Cited by 122 · see citing works

Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals

Brandt, J., Schrauth, S., Veith, A.-M., Froschauer, A., Haneke, T., Schultheis, C., Gessler, M., Leimeister, C., & Volff, J. (2004) · Gene · doi:10.1016/j.gene.2004.11.022 · Cited by 116 · see citing works

LINE-1 methylation patterns of different loci in normal and cancerous cells

Phokaew, C., Kowudtitham, S., Subbalekha, K., Shuangshoti, S., & Mutirangura, A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn571 · Cited by 109 · see citing works

The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination

Buzdin, A. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg496 · Cited by 105 · see citing works

Activation of Human Long Interspersed Nuclear Element 1 Retrotransposition by Benzo( a )pyrene, an Ubiquitous Environmental Carcinogen

Stribinskis, V., & Ramos, K. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3478 · Cited by 104 · see citing works

Many LINE1 elements contribute to the transcriptome of human somatic cells

Rangwala, S. H., Zhang, L., & Kazazian, H. H. (2009) · Genome Biology · doi:10.1186/gb-2009-10-9-r100 · Cited by 102 · see citing works

A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon

Soifer, H. S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki223 · Cited by 98 · see citing works

Cell Divisions Are Required for L1 Retrotransposition

Shi, X., Seluanov, A., & Gorbunova, V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01888-06 · Cited by 93 · see citing works

A large genomic deletion in thePDHX gene caused by the retrotranspositional insertion of a full-length LINE-1 element

Miné, M., Chen, J., Brivet, M., Desguerre, I., Marchant, D., de Lonlay, P., Aral, B., Férec, C., Abitbol, M. M., Ricquier, D., et al. (2006) · Human Mutation · doi:10.1002/humu.20449 · Cited by 81 · see citing works

Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling

Lucchinetti, E., Feng, J., da Silva, R., Tolstonog, G. V., SCHAUB, M. C., Schumann, G. G., & Zaugg, M. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00251.2005 · Cited by 81 · see citing works

Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control1

Xu, M., You, Y., Hunsicker, P. R., Hori, T., Small, C. L., Griswold, M. D., & Hecht, N. B. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.068072 · Cited by 79 · see citing works

DNA double-strand breaks: A potential causative factor for mammalian aging?

Li, H., Mitchell, J. R., & Hasty, P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.002 · Cited by 74 · see citing works

Decreased methylation of the major mouse long interspersed repeated DNA during aging and in myeloma cells

Mays-Hoopes, L. L., Wei, C., Butcher, H. C., & Huang, R. C. C. (1986) · Developmental Genetics · doi:10.1002/dvg.1020070202 · Cited by 72 · see citing works

Frequency of spontaneous chromosome aberrations in mice: effects of age

Tucker, J. D., Spruill, M., Ramsey, M. J., Director, A. D., & Nath, J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00036-6 · Cited by 71 · see citing works

Comparative expression of the LINE-1 p40 protein in human breast carcinomas and normal breast tissues.

Asch, H. L., Eliacin, E., Fanning, T. G., Connolly, J., Bratthauer, G. L., & Asch, B. B. (1996) · PubMed · Cited by 67 · see citing works

Genome instability and DNA repair in brain, ageing and neurological disease

Bohr, V. A., Ottersen, O. P., & Tønjum, T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.015 · Cited by 63 · see citing works

Downstream 28S Gene Sequences on the RNA Template Affect the Choice of Primer and the Accuracy of Initiation by the R2 Reverse Transcriptase

Luan, D. D., & Eickbush, T. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4726 · Cited by 62 · see citing works

Tissue-specific accelerated aging in nucleotide excision repair deficiency

Niedernhofer, L. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.010 · Cited by 60 · see citing works

The structures of mouse and human L1 elements reflect their insertion mechanism

Martin, S. L., Li, W.-L. P., Furano, A. V., & Boissinot, S. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084956 · Cited by 58 · see citing works

DNA damage, DNA repair, ageing and age-related disease

Wilson, D. M., Bohr, V. A., & McKinnon, P. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.013 · Cited by 56 · see citing works

Host defenses to transposable elements and the evolution of genomic imprinting

McDonald, J. F., Matzke, M. A., & Matzke, A. J. M. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084958 · Cited by 55 · see citing works

Frequent emergence and functional resurrection of processed pseudogenes in the human and mouse genomes

Sakai, H., Koyanagi, K. O., Imanishi, T., Itoh, T., & Gojobori, T. (2006) · Gene · doi:10.1016/j.gene.2006.11.007 · Cited by 52 · see citing works

Identifying related L1 retrotransposons by analyzing 3' transduced sequences

Szak, S. T., Pickeral, O. K., Landsman, D., & Boeke, J. D. (2003) · Genome biology · doi:10.1186/gb-2003-4-5-r30 · Cited by 43 · see citing works

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging

Akbari, M., & Krokan, H. E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.01.007 · Cited by 42 · see citing works

Mobile Genetic Element Activation and Genotoxic Cancer Therapy

Hagan, C. R., & Rudin, C. M. (2002) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200202010-00003 · Cited by 42 · see citing works

Different Rates of LINE-1 (L1) Retrotransposon Amplification and Evolution in New World Monkeys

Boissinot, S., Roos, C., & Furano, A. V. (2004) · Journal of Molecular Evolution · doi:10.1007/s00239-003-2539-x · Cited by 39 · see citing works

Detection of two Alu insertions in the CFTR gene

Chen, J., Masson, E., Maçek, M., Raguénès, O., Piskackova, T., Fercot, B., Fila, L., Cooper, D. N., Audrézet, M., & Férec, C. (2007) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2007.04.001 · Cited by 37 · see citing works

Between Scylla and Charybdis: p53 links tumor suppression and aging

Campisi, J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00006-4 · Cited by 33 · see citing works

Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma

Rockwood, L. D., Felix, K., & Janz, S. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.01.005 · Cited by 26 · see citing works

L1 retrotransposon-mediated stable gene silencing

Yang, N. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni056 · Cited by 24 · see citing works

Methylation mystery

Ronemus, M., & Martienssen, R. A. (2005) · Nature · doi:10.1038/433472a · Cited by 23 · see citing works

The L1 Retrotranspositional Stimulation by Particulate and Soluble Cadmium Exposure is Independent of the Generation of DNA Breaks

Kale, S. P., Carmichael, M. C., Harris, K., & Roy‐Engel, A. M. (2006) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph2006030015 · Cited by 21 · see citing works

Antagonistic pleiotropy and the stress theory of aging

Parsons, P. A. (2007) · Biogerontology · doi:10.1007/s10522-007-9101-y · Cited by 17 · see citing works

The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer

Martin, G. M. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.003 · Cited by 16 · see citing works

Molecular and Temporal Characteristics of Human Retropseudogenes

Devor, E. J., & Moffat-Wilson, K. A. (2003) · Human Biology · doi:10.1353/hub.2003.0075 · Cited by 16 · see citing works

Extrachromosomal Circular DNA and Aging Cells

Lumpkin, C. K., McGill, J. R., Riabowol, K. T., Moerman, E. J., Reis, R. J. S., & Goldstein, S. (1985) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7853-2_24 · Cited by 7 · see citing works

The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis

Neidhart (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200012)43:12 · Cited by 1 · see citing works

LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation

Simon, M., Van Meter, M., Ablaeva, J., Ke, Z., Gonzalez, R. S., Taguchi, T., De Cecco, M., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.014 · Cited by 498 · see citing works

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 455 · see citing works

Restricting retrotransposons: a review

Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436 · see citing works

The role of DNA damage and repair in aging through the prism of Koch-like criteria

Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

De Cecco, M., Criscione, S. W., Peterson, A. L., Neretti, N., Sedivy, J. M., & Kreiling, J. A. (2013) · Aging · doi:10.18632/aging.100621 · Cited by 365 · see citing works

Effect of aging on stem cells

Ahmed, A. S. I., Sheng, M. H. ‐., Wasnik, S., Baylink, D. J., & Lau, K. ‐. W. (2017) · World Journal of Experimental Medicine · doi:10.5493/wjem.v7.i1.1 · Cited by 202 · see citing works

Retrotransposition is associated with genome instability during chronological aging

Maxwell, P. H., Burhans, W. C., & Curcio, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100271108 · Cited by 132 · see citing works

Chromatin structure and transposable elements in organismal aging

Wood, J. G., & Helfand, S. L. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00274 · Cited by 124 · see citing works

Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

Wolf, G., Greenberg, D., & Macfarlan, T. S. (2015) · Mobile DNA · doi:10.1186/s13100-015-0050-8 · Cited by 109 · see citing works

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression

de Thé, F.-X. B., Rekaik, H., Pezé-Heidsieck, E., Massiani-Beaudoin, O., Joshi, R. L., Fuchs, J., & Prochiantz, A. (2018) · The EMBO Journal · doi:10.15252/embj.201797374 · Cited by 94 · see citing works

Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression

Sun, X., Wang, X., Tang, Z., Grivainis, M., Kahler, D. J., Yun, C., Mita, P., Fenyö, D., & Boeke, J. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722565115 · Cited by 92 · see citing works

SIRT7 in the aging process

Lagunas‐Rangel, F. A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04342-x · Cited by 89 · see citing works

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

Sarlak, G., Jenwitheesuk, A., Chetsawang, B., & Govitrapong, P. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r01sr · Cited by 87 · see citing works

Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study

van Hoesel, A. Q., van de Velde, C. J. �., Kuppen, P. J. K., Liefers, G., Putter, H., Sato, Y., Elashoff, D. A., Turner, R. R., Shamonki, J. M., de Kruijf, E. M., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2038-0 · Cited by 85 · see citing works

Death by transposition – the enemy within?

Sedivy, J. M., Kreiling, J. A., Neretti, N., Cecco, M. D., Criscione, S. W., Hofmann, J. W., Zhao, X., Ito, T., & Peterson, A. L. (2013) · BioEssays · doi:10.1002/bies.201300097 · Cited by 61 · see citing works

The role of transposable elements activity in aging and their possible involvement in laminopathic diseases

Andrenacci, D., Cavaliere, V., & Lattanzi, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100995 · Cited by 58 · see citing works

Aryl hydrocarbon receptor (AhR) reveals evidence of antagonistic pleiotropy in the regulation of the aging process

Salminen, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04520-x · Cited by 56 · see citing works

LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease

Mathavarajah, S., & Dellaire, G. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2023-0134 · Cited by 50 · see citing works

Retrotransposons as a Source of DNA Damage in Neurodegeneration

Pezé-Heidsieck, E., Bonnifet, T., Znaidi, R., Ravel‐Godreuil, C., Massiani-Beaudoin, O., Joshi, R. L., & Fuchs, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.786897 · Cited by 49 · see citing works

The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer’s Disease?

Sarlak, G., & Vincent, B. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9123-4 · Cited by 48 · see citing works

Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline

Potabattula, R., Zacchini, F., Ptak, G., Dittrich, M. T., Müller, T., Hajj, N. E., Hahn, T., Drummer, C., Behr, R., Lucas‐Hahn, A., et al. (2020) · Aging Cell · doi:10.1111/acel.13181 · Cited by 46 · see citing works

Organ-, sex- and age-dependent patterns of endogenous L1 mRNA expression at a single locus resolution

Stow, E. C., Kaul, T. K., deHaro, D. L., Dem, M. R., Beletsky, A. G., Morales, M. E., Du, Q., LaRosa, A. J., Yang, H., Smither, E., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab369 · Cited by 36 · see citing works

The association between personal sun exposure, serum vitamin D and global methylation in human lymphocytes in a population of healthy adults in South Australia

Nair‐Shalliker, V., Dhillon, V. S., Clements, M., Armstrong, B. K., & Fenech, M. F. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.04.001 · Cited by 34 · see citing works

Methods for the discovery of new anti-aging products – targeted approaches

Manayi, A., Saeidnia, S., Gohari, A. R., & Abdollahi, M. R. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.885014 · Cited by 32 · see citing works

Population and clinical genetics of human transposable elements in the (post) genomic era

Rishishwar, L., Wang, L., Clayton, E. A., Mariño‐Ramírez, L., McDonald, J. F., & Jordan, I. K. (2017) · Mobile Genetic Elements · doi:10.1080/2159256x.2017.1280116 · Cited by 32 · see citing works

Reactivation of retrotransposable elements is associated with environmental stress and ageing

Valle, F. D., Reddy, P., Aguirre-Vázquez, A., & Belmonte, J. C. I. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00829-y · Cited by 27 · see citing works

Mitochondrial DNA and Epigenetics: Investigating Interactions with the One‐Carbon Metabolism in Obesity

Bordoni, L., Petracci, I., Młodzik-Czyżewska, M. A., Malinowska, A. M., Szwengiel, A., Sadowski, M., Gabbianelli, R., & Chmurzyńska, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9171684 · Cited by 26 · see citing works

Transcriptional repression of repeat-derived transcripts correlates with histone hypoacetylation at repetitive DNA elements in aged mice brain.

Ryu, S. H., Kang, K., Yoo, T., Joe, C., & Chung, J. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.07.001 · Cited by 28 · see citing works

Retroelement-derived RNA and its role in the brain

Evans, T. A., & Erwin, J. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.11.001 · Cited by 25 · see citing works

Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis

Cadalbert, L. C., Ghaffar, F. N., Stevenson, D., Bryson, S., Vaz, F. M., Gottlieb, E., & Strathdee, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131066 · Cited by 24 · see citing works

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

Xu, Y., Zhang, L., Thaiparambil, J. T., Mai, S., Perera, D. N., Zhang, J., Pan, P., Coarfa, C., Ramos, K. S., Chen, S., et al. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0057 · Cited by 20 · see citing works

Extension of Saccharomyces paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species

VanHoute, D., & Maxwell, P. H. (2014) · Genetics · doi:10.1534/genetics.114.168799 · Cited by 19 · see citing works

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

Loh, D., & Reiter, R. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158122 · Cited by 17 · see citing works

Expression of a LINE-1 endonuclease variant in gastric cancer: its association with clinicopathological parameters

Wang, G., Gao, J., Huang, H., Tian, Y., Xue, L., Wang, W., You, W.-D., Lian, H., Duan, X., Wu, B., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-265 · Cited by 17 · see citing works

A Single Whole-Body Low Dose X-Irradiation Does Not Affect L1, B1 and IAP Repeat Element DNA Methylation Longitudinally

Newman, M. R., Sykes, P. J., Blyth, B. J., Bezak, E., Lawrence, M. D., Morel, K. L., & Ormsby, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093016 · Cited by 15 · see citing works

Intercellular viral spread and intracellular transposition of Drosophila gypsy

Keegan, R. M., Talbot, L. R., Chang, Y.-H., Metzger, M. J., & Dubnau, J. (2021) · PLOS Genetics · doi:10.1371/journal.pgen.1009535 · Cited by 14 · see citing works

Fetal Programming of Renal Development?Influence of Maternal Smoking

Chen, H., Al‐Odat, I., Pollock, C. A., & Saad, S. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s9-003 · Cited by 13 · see citing works

Navigating the brain and aging: exploring the impact of transposable elements from health to disease

Breton, A. L., Bettencourt, M. P., & Gendrel, A.-V. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1357576 · Cited by 12 · see citing works

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

Switzer, C. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16302 · Cited by 10 · see citing works

Genetic instability and aging under the scrutiny of comparative biology: a meta-analysis of spontaneous micronuclei frequency

Croco, E., Marchionni, S., & Lorenzini, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.04.004 · Cited by 10 · see citing works

Human L1 Transposition Dynamics Unraveled with Functional Data Analysis

Chen, D., Cremona, M. A., Qi, Z., Mitra, R. D., Chiaromonte, F., & Makova, K. D. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa194 · Cited by 7 · see citing works

Stress cycles in stem cells/iPSCs development: implications for tissue repair

Grafi, G. (2013) · Biogerontology · doi:10.1007/s10522-013-9445-4 · Cited by 7 · see citing works

Transposon Activity in Plant Genomes

Gözükırmızı, N., Temel, A., Maraklı, S., & Yılmaz, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-31703-8_4 · Cited by 7 · see citing works

ELISA-based detection of Open Reading Frame protein 1 in patients at risk of developing lung cancer

Sharp, C. N., Korte, E. A., Hosseinnejad, K., Pitman, J., Lavasanifar, A., Eichenberger, D. J., Sephton, S. E., Cash, E. D., & Jortani, S. A. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.005 · Cited by 6 · see citing works

Good, bad, mobile elements: genome's most successful "parasites" as emerging players in cell and organismal aging.

Cardelli, M., & Marchegiani, F. (2013) · Current pharmaceutical design · doi:10.2174/1381612811319090021 · Cited by 6 · see citing works

The Ultraviolet Irradiation of Keratinocytes Induces Ectopic Expression of LINE-1 Retrotransposon Machinery and Leads to Cellular Senescence

Touma, F., Lambert, M., Villarreal, A. M., Gantchev, J. K., Ramchatesingh, B. L., & Litvinov, I. V. (2023) · Biomedicines · doi:10.3390/biomedicines11113017 · Cited by 6 · see citing works

Cell-host, LINE and environment

Re, B. D., & Giorgi, G. (2013) · Mobile Genetic Elements · doi:10.4161/mge.24040 · Cited by 6 · see citing works

LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition

Mehmood, A., Xue, Y., Yassin, H. M., Zubair, M. A., Rahmat, S. A., & Ahmad, A. (2025) · Współczesna Onkologia · doi:10.5114/wo.2025.152369 · Cited by 5 · see citing works

Therapeutic value of homeoprotein signaling pathways

Nardo, A. A. D., & Prochiantz, A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1359523 · Cited by 4 · see citing works

Useful parasites: the evolutionary biology and biotechnology applications of transposable elements

Bonchev, G. (2016) · Journal of Genetics · doi:10.1007/s12041-016-0702-6 · Cited by 4 · see citing works

An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted GerotherapeuticsPreprint

Anderson, P. L., Pang, A. P. S., Coyle, R. P., Schlachetzki, J. C. M., Molina, A. J. A., Bushman, L. R., Aguado, J., Hill, R. B., Liu, A., Brooks, K. M., et al. (2026) · medRxiv · doi:10.64898/2026.03.23.26349105 · Cited by 4 · see citing works

Repetitive Sequence Stability in Embryonic Stem Cells

Shi, G. W., Pang, Q., Lin, Z., Zhang, X., & Huang, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168819 · Cited by 3 · see citing works

[Dacron and polytetrafluoroethylene aorto-bifemoral grafts].

Davidovic, L. B., Lotina, S. I., Kostic, D. M., Cinara, I., Cvetkovic, S. D., Stojanović, P. L., Velimirović, L. B., Markovic, D. M., Pejkić, S., & Pavlović, G. (1997) · PubMed · Cited by 3 · see citing works

Retrotransposons and Human Disease

Roy‐Engel, A. M., & Belancio, V. P. (2011) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0005492.pub2 · Cited by 2 · see citing works

MORE-RNAseq: a pipeline for quantifying retrotransposition-capable LINE1 expression based on RNA-seq data

Nakachi, Y., Du, J., Watanabe, R., Yanagida, Y., Bundo, M., & Iwamoto, K. (2025) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2025.1575346 · Cited by 1 · see citing works

Aging-induced stem cell dysfunction: Molecular mechanisms and potential therapeutic avenues

Grajeda, Y., Arias, N., Barrios, A., Pervin, S., & Singh, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00005-0 · Cited by 1 · see citing works

Retrotransposons as both “architects” and “saboteurs” in the nervous system

Izquierdo‐Useros, N., Dierssen, M., Clotet, B., Elizalde‐Torrent, A., & Carriba, P. (2025) · Advances in genetics · doi:10.1016/bs.adgen.2025.11.002 · Cited by 1 · see citing works

Dietary Restriction, Dietary Design and the Epigenetics of Aging and Longevity

Cooney, C. A. (2014) · Healthy ageing and longevity · doi:10.1007/978-3-319-14830-4_2 · Cited by 1 · see citing works

Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout micePreprint

Simon, M., Meter, M. V., Ablaeva, J., Ke, Z., González, R. S., Taguchi, T., Cecco, M. D., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/460808 · Cited by 1 · see citing works

High expression levels and nuclear localization of novel Danio rerio ncRNA transcribed from a genomic region containing repetitive elements

Shubernetskaya, O. S., Skvortsov, D. A., Evfratov, S. A., Rubtsova, M. P., Belova, E. V., Strelkova, O. S., Cherepaninets, V. D., Zhironkina, O. A., Olovnikov, A. M., Zvereva, M. I., et al. (2014) · Molecular Biology · doi:10.1134/s002689331404013x

Human lifespan: what determines the intrinsic length of human lives?

Crosse, D. J. (2011) · Reviews in Clinical Gerontology · doi:10.1017/s0959259811000062

Generation Of Humanized Models For The Understanding Of Health And Aging

Kraus, M. (2015) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.32656

The Effects of Exercise on LINE-1 Regulation

Romero, M. A. (2019)

Processus morphogénétiques

Prochiantz, A. (2015) · L’annuaire du Collège de France · doi:10.4000/annuaire-cdf.11906

In celebration of women in developmental epigenetics

(2024) · Frontiers research topics · doi:10.3389/978-2-8325-5657-3

L1 retrotransposon activity in muscle cells

Lopez, P. P. (2020) · doi:10.70675/d6a87136z1044z4451z9156z5fd79eb81aff

Variation in LINE-1 ORF1p expression across histologic and demographic subgroups in non-small cell lung cancers

Wang, Y., Li, C., Nguyen, K., Powell, R., Kondapaneni, M., & Ramos, K. S. (2026) · Translational Oncology · doi:10.1016/j.tranon.2026.102849

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer’s DiseasePreprint

Herdy, J. R., Taylor, E. E., Karbacher, L., Borgogno, O., Traxler, L., Lagerwall, J., Huynh, V. A., Lefterova, Z. V., Kang, A., Tosat‐Bitrián, C., et al. (2026) · SSRN Electronic Journal · doi:10.64898/2026.07.27.740588

LINE-1 Retrotransposition Increases with Age in Rodent Skeletal Muscle

Mumford, P. W., Romero, M. A., Osburn, S. C., Roberson, P. A., Young, K. C., & Roberts, M. D. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000561998.84264.2b

LINE-1 transposable element renaissance in aging and age-related diseases

Li, X., Yu, H., Li, D., & Liu, N. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102440 · Cited by 23 · see citing works

Antagonistic regulation of LINE-1/Alu elements and their repressor APOBEC3B in cellular senescence

Munot, D., Lu, Y., Haußmann, I., Najjar, G., Baur, C., Singh, M. K., Güneş, Ç., Sauter, D., & Arora, A. V. (2025) · Mobile DNA · doi:10.1186/s13100-025-00378-5 · Cited by 1 · see citing works

Inhibition of ‘jumping genes’ promotes healthy ageing

Childs, B. G., & van Deursen, J. (2019) · Nature · doi:10.1038/d41586-018-07553-0 · Cited by 11 · see citing works

Regulation of human LINE-1 activity and integration specificity by L1-EN mutations, DSB repair proteins and the application of the Tet/Dox-inducible eypression system

Layer, L. E. (2016) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)