Cited by 129HIV Research and TreatmentT-cell and Retrovirus StudiesHIV/AIDS drug development and treatment

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Molecular Determinants that Regulate Plasma Membrane Association of HIV-1 Gag

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Chukkapalli, Vineela, Ono, Akira·2011·Journal of Molecular Biology

DOI 10.1016/j.jmb.2011.04.015PMC PMC3139151

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Abstract

Human immunodeficiency virus type 1 assembly is a multistep process that occurs at the plasma membrane (PM). Targeting and binding of Gag to the PM are the first steps in this assembly process and are mediated by the matrix domain of Gag. This review highlights our current knowledge on viral and cellular determinants that affect specific interactions between Gag and the PM. We will discuss potential mechanisms by which the matrix domain might integrate three regulatory components, myristate, phosphatidylinositol-(4,5)-bisphosphate, and RNA, to ensure that human immunodeficiency virus type 1 assembly occurs at the PM.

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“Later it became apparent that Gag localization to the plasma membrane is contingent on interactions between the HBR and phosphatidylinositol 4,5-bisphosphate (PIP 2 ) (Ono et al. 2004 , Chukkapalli et al. 2008 , Chukkapalli and Ono 2011 , Dick et al. 2012 ).”
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Authors: Chukkapalli, V., & Ono, A.
Affiliations: University of Michigan (US)
Corresponding author: Ono, Akira
ORCID: Ono, Akira
Venue: Journal of Molecular Biology
Publisher: Elsevier BV
Published: 2011-07
Volume: 410
Issue: 4
Pages: 512-524
ISSN: 0022-2836 (ISSN-L)
DOI: 10.1016/j.jmb.2011.04.015
PMC: PMC3139151
OpenAlex: W1982692592
Cited by: 129
References: 121
Citations by year: 2026: 3 · 2025: 3 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 12 · 2012: 11
FWCI: 1.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R56AI089282, R01AI071727)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: HIV-1, Gag, matrix domain, plasma membrane association, viral assembly, myristoylation, phosphatidylinositol 4,5-bisphosphate, RNA binding, membrane targeting
MeSH terms: Amino Acid Sequence, Cell Membrane, Humans, Membrane Lipids, Molecular Sequence Data, Protein Binding, Viral Matrix Proteins, HIV-1, gag Gene Products, Human Immunodeficiency Virus

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Molecular Determinants that Regulate Plasma Membrane Association of HIV-1 Gag

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