Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton
Abstract
Cell contact is required for efficient transmission of human T cell leukemia virus– type 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not understood. We show here that cell contact rapidly induces polarization of the cytoskeleton of the infected cell to the cell-cell junction. HTLV-I core (Gag protein) complexes and the HTLV-I genome accumulate at the cell-cell junction and are then transferred to the uninfected cell. Other lymphotropic viruses, such as HIV-1, may similarly subvert normal T cell physiology to allow efficient propagation between cells.
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MTOC polarization facilitates actin- and tubulin-dependent accumulation of Gag, Env, and viral RNA in the intercellular contact zone.
“MTOC polarization facilitates the actin- and tubulin-dependent accumulation of Gag, Env, and viral RNA in the intercellular contact zone [34,39].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [34]
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- Authors
- Igakura, T., Stinchcombe, J. C., Goon, P. K. C., Taylor, G. P., Weber, J. N., Griffiths, G. M., Tanaka, Y., Osame, M., & Bangham, C. R. M.
- Affiliations
- Kagoshima University (JP)
- University of Oxford (GB)
- Department of Immunology,
- Imperial College London (GB)
- University of the Ryukyus (JP)
- Corresponding author
- Bangham, Charles R. M.
- ORCID
- Venue
- Science
- Published
- 2003-03-14
- Volume
- 299
- Issue
- 5613
- Pages
- 1713-1716
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027209056
- Cited by
- 755
- References
- 1
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 23 · 2023: 24 · 2022: 38 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 25 · 2017: 32 · 2016: 28 · 2015: 31 · 2014: 39 · 2013: 30 · 2012: 38
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Virus Research Studies
- Keywords
- HTLV-1, cell-to-cell transmission, cell-cell junction, Gag protein, lymphocytes, HIV-1, viral propagation
- MeSH terms
- Cell Communication, Cell Line, Extracellular Space, Humans, Intercellular Junctions, Microtubules, Receptors, Antigen, T-Cell, T-Lymphocytes, Virion, Human T-lymphotropic virus 1, HTLV-I Infections, CD4-Positive T-Lymphocytes, Gene Products, gag, Gene Products, env, Cell Adhesion Molecules, Talin, Genome, Viral, Cell Polarity, In Situ Hybridization, Fluorescence, CD8-Positive T-Lymphocytes, Microscopy, Confocal, Nucleocapsid Proteins, Peptide Nucleic Acids, Microtubule-Organizing Center
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