The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol
Open accessAbstract
HOTAIR is a long noncoding RNA (lncRNA) that is transcribed from the antisense strand of HOXC gene locus in chromosome 12. HOTAIR coordinates with chromatin modifying enzymes and regulates gene silencing. It is overexpressed in various carcinomas including breast cancer. Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Its promoter contains multiple functional estrogen-response-elements (EREs). Estrogen receptors (ERs) along with various ER-coregulators such as histone methylases MLL1 and MLL3 and CBP/p300 bind to the promoter of HOTAIR in an E2-dependent manner. Level of histone H3K4-trimethylation, histone acetylation and RNA polymerase II recruitment is enriched at the HOTAIR promoter in presence of E2. Knockdown of ERs and MLLs down regulated the E2-induced HOTAIR expression. Thus, similar to protein coding gene transcription, E2-induced transcription of antisense transcript HOTAIR is coordinated via ERs and ER-coregulators and this mechanism of HOTAIR over expression potentially contributes towards breast cancer progression.
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“ed recruitment of the PRC2 complex and the LSD1– CoREST–REST complex.(12) HOTAIR aids in promoting genome-wide chromatin reprogramming and coordinates in long-range gene expression and regulation.”
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Cited by
Functions of lncRNA HOTAIR in lung cancer
Loewen, G., Jayawickramarajah, J., Zhuo, Y., & Shan, B. (2014) · Journal of Hematology & Oncology · doi:10.1186/s13045-014-0090-4 · Cited by 454
The bright side of dark matter: lncRNAs in cancer
Evans, J. R., Feng, F. Y., & Chinnaiyan, A. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84421 · Cited by 451
Long non-coding RNAs as emerging regulators of differentiation, development, and disease
Dey, B. K., Mueller, A. C., & Dutta, A. (2014) · Transcription · doi:10.4161/21541272.2014.944014 · Cited by 324
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
Bhan, A., & Mandal, S. S. (2014) · ChemMedChem · doi:10.1002/cmdc.201300534 · Cited by 279
Self-citationLong noncoding RNAs: a potential novel class of cancer biomarkers
Yarmishyn, A. A., & Kurochkin, I. V. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00145 · Cited by 273
Metadata
- Authors
- Bhan, A., Hussain, I., Ansari, K. I., Kasiri, S., Bashyal, A., & Mandal, S. S.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 425
- Issue
- 19
- Pages
- 3707-3722
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2024148591
- Cited by
- 262
- References
- 6
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Bhan, A., Hussain, I., Ansari, K. I., Kasiri, S., Bashyal, A., & Mandal, S. S. (2013). Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol. Journal of Molecular Biology. https://doi.org/10.1016/j.jmb.2013.01.022
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