The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Insect Antiviral Innate Immunity: Pathways, Effectors, and Connections
Open accessAbstract
Insects are infected by a wide array of viruses some of which are insect-restricted and pathogenic, and some of which are transmitted by biting insects to vertebrates. The medical and economic importance of these viruses heightens the need to understand the interaction between the infecting pathogen and the insect immune system in order to develop transmission interventions. The interaction of the virus with the insect host innate immune system plays a critical role in the outcome of infection. The major mechanism of antiviral defense is the siRNA pathway that responds through the detection of virus-derived dsRNA to suppress virus replication. However, other innate antimicrobial pathways such as Imd, Toll, Jak-STAT, and the autophagy pathway have also been shown to play important roles in antiviral immunity. In this review we provide an overview of the current understanding of the main insect antiviral pathways and examine recent findings that further our understanding of the roles of these pathways in facilitating a systemic and specific response to infecting viruses.
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Cited by
Insect immunology and hematopoiesis
Hillyer, J. F. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.12.006 · Cited by 561
Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges
Christiaens, O., Whyard, S., Vélez, A. M., & Smagghe, G. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00451 · Cited by 339
Alton, L. A., Novelo, M., Beaman, J. E., Arnold, P. A., Bywater, C. L., Kerton, E. J., Lombardi, E. J., Koh, C., & McGraw, E. A. (2023) · Global Change Biology · doi:10.1111/gcb.16906 · Cited by 6
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Metadata
- Authors
- Kingsolver, M. B., Huang, Z., & Hardy, R. W.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 425
- Issue
- 24
- Pages
- 4921-4936
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2085030395
- Cited by
- 349
- References
- 134
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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