The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges
Open accessAbstract
Exploiting the RNA interference (RNAi) gene mechanism to silence essential genes in pest insects, leading to toxic effects, has surfaced as a promising new control strategy in the past decade. While the first commercial RNAi-based products are currently coming to market, the application against a wide range of insect species is still hindered by a number of challenges. In this review, we discuss the current status of these RNAi-based products and the different delivery strategies by which insects can be targeted by the RNAi-triggering double-stranded RNA (dsRNA) molecules. Furthermore, this review also addresses a number of physiological and cellular barriers, which can lead to decreased RNAi efficacy in insects. Finally, novel non-transgenic delivery technologies, such as polymer or liposomic nanoparticles, peptide-based delivery vehicles and viral-like particles, are also discussed, as these could overcome these barriers and lead to effective RNAi-based pest control.
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Citations
Cites
Pesticide Exposure, Safety Issues, and Risk Assessment Indicators
Damalas, C. A., & Eleftherohorinos, I. G. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8051402 · Cited by 2,426
Chemical Pesticides and Human Health: The Urgent Need for a New Concept in Agriculture
Nicolopoulou-Stamati, P., Maipas, S., Kotampasi, C., Stamatis, P., & Hens, L. (2016) · Frontiers in Public Health · doi:10.3389/fpubh.2016.00148 · Cited by 1,880
Control of coleopteran insect pests through RNA interference
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IRAC: Mode of action classification and insecticide resistance management
Sparks, T. C., & Nauen, R. (2015) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2014.11.014 · Cited by 1,366
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
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Clay nanosheets for topical delivery of RNAi for sustained protection against plant viruses
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Mechanisms of dsRNA uptake in insects and potential of RNAi for pest control: A review
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Self-citationTerenius, O., Papanicolaou, A., Garbutt, J. S., Eleftherianos, I., Huvenne, H., Kanginakudru, S., Albrechtsen, M., An, C., Aymeric, J.-L., Barthel, A., et al. (2011) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2010.11.006 · Cited by 864
Self-citationDistinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
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Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing
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Metadata
- Authors
- Christiaens, O., Whyard, S., Vélez, A. M., & Smagghe, G.
- Venue
- Frontiers in Plant Science
- Publisher
- Frontiers Media SA
- Published
- 2020-04-21
- Volume
- 11
- Pages
- 451-451
- ISSN
- 1664-462X (ISSN-L)
- OpenAlex
- W3016276978
- Cited by
- 339
- References
- 86
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
