The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
An overview of macroautophagy in yeast
Open accessAbstract
Macroautophagy is an evolutionarily conserved dynamic pathway that functions primarily in a degradative manner. A basal level of macroautophagy occurs constitutively, but this process can be further induced in response to various types of stress including starvation, hypoxia and hormonal stimuli. The general principle behind macroautophagy is that cytoplasmic contents can be sequestered within a transient double-membrane organelle, an autophagosome, which subsequently fuses with a lysosome or vacuole (in mammals, or yeast and plants, respectively), allowing degradation of the cargo followed by recycling of the resulting macromolecules. Through this basic mechanism, macroautophagy has a critical role in cellular homeostasis; however, either insufficient or excessive macroautophagy can seriously compromise cell physiology, and thus it needs to be properly regulated. In fact, a wide range of diseases is associated with dysregulation of macroautophagy. There has been substantial progress in understanding the regulation and molecular mechanisms of macroautophagy in different organisms; however, many questions concerning some most fundamental aspects of macroautophagy still remain unresolved. In this review, we summarize current knowledge about macroautophagy mainly in yeast, including the mechanism of autophagosome biogenesis, the function of the core macroautophagic machinery, the regulation of macroautophagy, and the process of cargo recognition in selective macroautophagy, with the goal of providing insights into some of the key unanswered questions in this field.
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Cited by
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Metadata
- Authors
- Wen, X., & Klionsky, D. J.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 428
- Issue
- 9
- Pages
- 1681-1699
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2278612953
- Cited by
- 265
- References
- 193
- FWCI
- 20.72
- Type
- journal article
- Language
- en
- Open access
- green
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