Cited by 55Autophagy in Disease and TherapyAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

The contribution of altered neuronal autophagy to neurodegeneration

Open access
Filippone, Alessia, Esposito, Emanuela, Mannino, Deborah, Lyssenko, Nicholas, Praticò, Domenico·2022·Pharmacology & Therapeutics

Abstract

Defects in cellular functions related to altered protein homeostasis and associated progressive accumulation of pathological intracellular material is a critical process involved in the pathogenesis of many neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Autophagy is an essential mechanism that ensures neuronal health by removing long-lived proteins or defective organelles and by doing so prevents cell toxicity and death within the central nervous system. Abundant evidence has shown that neuronal autophagy pathways are altered in Alzheimer's disease, Parkinson's disease and traumas of the central nervous system including Spinal Cord Injury and Traumatic Brain Injury. In this review, we aimed to summarize the latest studies on the role that altered neuronal autophagy plays in brain health and these pathological conditions, and how this knowledge can be leveraged for the development of novel therapeutics against them.

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Crossref · 10.1016/j.pharmthera.2022.108178

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  • Autophagy and microglial phagocytosis are impaired in AD and aged brains.

    “Extensive evidence shows that autophagy and microglial phagocytosis are impaired in AD and aged brains [24, 30, 94, 103].”

    From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [24]

    The section on neuronal autophagy dysfunction in Alzheimer’s and Parkinson’s diseases reports impaired autophagy in people with AD, supporting that part of the claim. The Introduction discusses microglial activation, not impaired microglial phagocytosis; the retrieved passages also do not establish impairment of both processes in aged brains. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 5

  1. Bellomo G, Paciotti S, Gatticchi L, and Parnetti L. The Vicious Cycle Between α-Synuclein Aggregation and Autophagic-Lysosomal Dysfunction. Movement Disorders, 1, 2020. Vol. 35. 31729779
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  3. Lin S, He Tian, Jiaquan Lin, Chang Xu, Yajiang Yuan, Shuang Gao, Changwei Song, Pengfei Lv, Xifan Mei. Zinc promotes autophagy and inhibits apoptosis through AMPK/mTOR signaling pathway after spinal cord injury. Neuroscience Letters. (2020) 25; 736: p135263. 32682846
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Authors
Filippone, A., Esposito, E., Mannino, D., Lyssenko, N., & Praticò, D.
Affiliations
  • University of Messina (IT)
  • Temple University (US)
Corresponding author
Praticò, Domenico
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2022-10
Volume
238
Pages
108178
ISSN
0163-7258 (ISSN-L)
OpenAlex
W4220759666
Cited by
55
References
98
Citations by year
2026: 7 · 2025: 13 · 2024: 11 · 2023: 16 · 2022: 8
FWCI
1.91
Type
journal article
Language
en
Open access
Locations
  • Pharmacology & Therapeutics (publishedVersion, cc-by-nc-nd)
  • SSRN Electronic Journal (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • TUScholarShare (Temple University) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institutes of Health (AG056689)
  • National Institute on Aging (AG055707)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neuronal autophagy, neurodegeneration, Alzheimer's disease, Parkinson's disease, proteostasis, protein aggregation, spinal cord injury, traumatic brain injury, neuroprotection
MeSH terms
Alzheimer Disease, Autophagy, Humans, Neurons, Parkinson Disease

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