The contribution of altered neuronal autophagy to neurodegeneration
Open accessAbstract
Defects in cellular functions related to altered protein homeostasis and associated progressive accumulation of pathological intracellular material is a critical process involved in the pathogenesis of many neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Autophagy is an essential mechanism that ensures neuronal health by removing long-lived proteins or defective organelles and by doing so prevents cell toxicity and death within the central nervous system. Abundant evidence has shown that neuronal autophagy pathways are altered in Alzheimer's disease, Parkinson's disease and traumas of the central nervous system including Spinal Cord Injury and Traumatic Brain Injury. In this review, we aimed to summarize the latest studies on the role that altered neuronal autophagy plays in brain health and these pathological conditions, and how this knowledge can be leveraged for the development of novel therapeutics against them.
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Autophagy and microglial phagocytosis are impaired in AD and aged brains.
“Extensive evidence shows that autophagy and microglial phagocytosis are impaired in AD and aged brains [24, 30, 94, 103].”
From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [24]
The section on neuronal autophagy dysfunction in Alzheimer’s and Parkinson’s diseases reports impaired autophagy in people with AD, supporting that part of the claim. The Introduction discusses microglial activation, not impaired microglial phagocytosis; the retrieved passages also do not establish impairment of both processes in aged brains. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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Self-citationExtra-virgin olive oil, cognition and brain health
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- Authors
- Filippone, A., Esposito, E., Mannino, D., Lyssenko, N., & Praticò, D.
- Affiliations
- University of Messina (IT)
- Temple University (US)
- Corresponding author
- Praticò, Domenico
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 238
- Pages
- 108178
- ISSN
- 0163-7258 (ISSN-L)
- PMC
- PMC9510148
- OpenAlex
- W4220759666
- Cited by
- 55
- References
- 98
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 11 · 2023: 16 · 2022: 8
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Pharmacology & Therapeutics (publishedVersion, cc-by-nc-nd)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- TUScholarShare (Temple University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (AG056689)
- National Institute on Aging (AG055707)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuronal autophagy, neurodegeneration, Alzheimer's disease, Parkinson's disease, proteostasis, protein aggregation, spinal cord injury, traumatic brain injury, neuroprotection
- MeSH terms
- Alzheimer Disease, Autophagy, Humans, Neurons, Parkinson Disease
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