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Cited by 1,956Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismUbiquitin and proteasome pathways

Mammalian autophagy: core molecular machinery and signaling regulation

Open access
Yang, Zhifen, Klionsky, Daniel J·2010·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2009.11.014PMC PMC2854249
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Abstract

Autophagy, a cellular catabolic pathway, is evolutionarily conserved from yeast to mammals. Central to this process is the formation of autophagosomes, double-membrane vesicles responsible for delivering long-lived proteins and excess or damaged organelle into the lysosome for degradation and reuse of the resulting macromolecules. In addition to the hallmark discovery of core molecular machinery components involved in autophagosome formation, complex signaling cascades controlling autophagy have also begun to emerge, with mTOR as a central but far from exclusive player. Malfunction of autophagy has been linked to a wide range of human pathologies, including cancer, neurodegeneration, and pathogen infection. Here we highlight the recent advances in identifying and understanding the core molecular machinery and signaling pathways that are involved in mammalian autophagy.

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Cited by

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Authors
Yang, Z., & Klionsky, D. J.
Affiliations
University of Michigan (US)
Corresponding author
Klionsky, Daniel J
ORCID
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2010-04
Volume
22
Issue
2
Pages
124-131
ISSN
0955-0674 (ISSN-L)
DOI
10.1016/j.ceb.2009.11.014
PMC
PMC2854249
OpenAlex
W1975915706
Cited by
1,956
References
10
Citations by year
2026: 32 · 2025: 59 · 2024: 94 · 2023: 102 · 2022: 115 · 2021: 137 · 2020: 152 · 2019: 142 · 2018: 121 · 2017: 122 · 2016: 151 · 2015: 136 · 2014: 168 · 2013: 161 · 2012: 145
FWCI
10.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (R01GM053396)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
autophagy, autophagosome formation, autophagy signaling, mTOR, lysosomal degradation, cancer, neurodegeneration, pathogen infection
MeSH terms
Animals, Autophagy, Humans, Mammals, Signal Transduction

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