Cited by 550Bacterial Genetics and BiotechnologyBiochemical and Structural CharacterizationGene Regulatory Network Analysis

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Molecular Mechanisms of Two-Component Signal Transduction

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Zschiedrich, Christopher P., Keidel, Victoria, Szurmant, Hendrik·2016·Journal of Molecular Biology

DOI 10.1016/j.jmb.2016.08.003PMC PMC5023499

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Abstract

Two-component systems (TCS) comprising sensor histidine kinases and response regulator proteins are among the most important players in bacterial and archaeal signal transduction and also occur in reduced numbers in some eukaryotic organisms. Given their importance to cellular survival, virulence, and cellular development, these systems are among the most scrutinized bacterial proteins. In the recent years, a flurry of bioinformatics, genetic, biochemical, and structural studies have provided detailed insights into many molecular mechanisms that underlie the detection of signals and the generation of the appropriate response by TCS. Importantly, it has become clear that there is significant diversity in the mechanisms employed by individual systems. This review discusses the current knowledge on common themes and divergences from the paradigm of TCS signaling. An emphasis is on the information gained by a flurry of recent structural and bioinformatics studies.

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1 retracted

RETRACTED: Cell–cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover
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Two-Component Signal Transduction
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Authors: Zschiedrich, C. P., Keidel, V., & Szurmant, H.
Affiliations: Scripps Research Institute (US)
Corresponding author: Szurmant, Hendrik
ORCID: Szurmant, Hendrik
Venue: Journal of Molecular Biology
Publisher: Elsevier BV
Published: 2016-09
Volume: 428
Issue: 19
Pages: 3752-3775
ISSN: 0022-2836 (ISSN-L)
DOI: 10.1016/j.jmb.2016.08.003
PMC: PMC5023499
OpenAlex: W2498485322
Cited by: 540
References: 189
Citations by year: 2026: 33 · 2025: 54 · 2024: 64 · 2023: 54 · 2022: 63 · 2021: 63 · 2020: 58 · 2019: 69 · 2018: 40 · 2017: 39 · 2016: 2
FWCI: 6.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: US National Institute of General Medical Sciences, National Institutes of Health (GM106085)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: two-component systems, signal transduction, sensor histidine kinase, response regulator proteins, bacterial signaling, signal detection, protein structure, molecular mechanisms
MeSH terms: Histidine Kinase, Archaea, Bacteria, Gene Expression Regulation, Transcription Factors, Signal Transduction, Eukaryota

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