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Molecular Mechanisms of Two-Component Signal Transduction
Open accessAbstract
Two-component systems (TCS) comprising sensor histidine kinases and response regulator proteins are among the most important players in bacterial and archaeal signal transduction and also occur in reduced numbers in some eukaryotic organisms. Given their importance to cellular survival, virulence, and cellular development, these systems are among the most scrutinized bacterial proteins. In the recent years, a flurry of bioinformatics, genetic, biochemical, and structural studies have provided detailed insights into many molecular mechanisms that underlie the detection of signals and the generation of the appropriate response by TCS. Importantly, it has become clear that there is significant diversity in the mechanisms employed by individual systems. This review discusses the current knowledge on common themes and divergences from the paradigm of TCS signaling. An emphasis is on the information gained by a flurry of recent structural and bioinformatics studies.
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“Typically, lemA is part of a two-component regulatory system, which have been well-studied across bacterial systems92−94 (but that have not yet been observed in Mycoplasma to our knowledge), and are involved in regulation of various cellular processes varying from phosphate uptake, to respiration, to sporulation.”
From Toward the Complete Functional Characterization of a Minimal Bacterial Proteome (2022) · cites this paper as [92]
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“lemA-gacS/0604 | cell growth and morphology | two component sensor/membrane”
From Toward the Complete Functional Characterization of a Minimal Bacterial Proteome (2022) · cites this paper as [92]
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RetractedTwo-Component Signal Transduction
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Metadata
- Authors
- Zschiedrich, C. P., Keidel, V., & Szurmant, H.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Szurmant, Hendrik
- ORCID
- Szurmant, Hendrik
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 428
- Issue
- 19
- Pages
- 3752-3775
- ISSN
- 0022-2836 (ISSN-L)
- PMC
- PMC5023499
- OpenAlex
- W2498485322
- Cited by
- 540
- References
- 189
- Citations by year
- 2026: 33 · 2025: 54 · 2024: 64 · 2023: 54 · 2022: 63 · 2021: 63 · 2020: 58 · 2019: 69 · 2018: 40 · 2017: 39 · 2016: 2
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- US National Institute of General Medical Sciences, National Institutes of Health (GM106085)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- two-component systems, signal transduction, sensor histidine kinase, response regulator proteins, bacterial signaling, signal detection, protein structure, molecular mechanisms
- MeSH terms
- Histidine Kinase, Archaea, Bacteria, Gene Expression Regulation, Transcription Factors, Signal Transduction, Eukaryota
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