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RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms
Open accessAbstract
G-quadruplexes are extremely stable DNA or RNA secondary structures formed by sequences rich in guanine. These structures are implicated in many essential cellular processes and the number of biological functions attributed to them continues to grow. While DNA G-quadruplexes are well understood on structural and to some extent on functional levels, RNA G-quadruplexes and their functions have received less attention. The presence of bona fide RNA G-quadruplexes in cells has long been a matter of debate. The development of G-quadruplex-specific antibodies and ligands hinted on their presence in vivo but recent advances in RNA sequencing coupled with chemical footprinting suggested the opposite. In this review, we will critically discuss the biology of RNA G-quadruplexes focusing on the molecular mechanisms underlying their proposed functions.
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“The pLenti CRISPR (pXPR) vector expressing Cas9 and the single guide (sg)RNAs that target ATG5 or ATG7 or non-specific sgRNA control were constructed and validated in the laboratory of Prof. Kevin M Ryan (Beatson Institute of Health, University of Glasgow).”
BackgroundResultInfluential
Metadata
- Authors
- Fay, M. M., Lyons, S. M., & Ivanov, P.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 429
- Issue
- 14
- Pages
- 2127-2147
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2619324489
- Cited by
- 447
- References
- 161
- FWCI
- 15.92
- Type
- journal article
- Language
- en
- Open access
- green
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