G-quadruplex unwinding helicases and their function in vivo
Open accessAbstract
The concept that G-quadruplex (G4) structures can form within DNA or RNA in vitro has been long known and extensively discussed. In recent years, accumulating evidences imply that G-quadruplex structures form in vivo. Initially, inefficient regulation of G-quadruplex structures was mainly associated with genome instability. However, due to the location of G-quadruplex motifs and their evolutionary conservation, different cellular functions of these structures have been postulated (e.g. in telomere maintenance, DNA replication, transcription, and translation). Regardless of their function, efficient and controlled formation and unwinding are very important, because ‘mis’-regulated G-quadruplex structures are detrimental for a given process, causing genome instability and diseases. Several helicases have been shown to target and regulate specific G-quadruplex structures. This mini-review focuses on the biological consequences of G4 disruption by different helicases in vivo.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent studies have demonstrated the involvement of G4s in inducing or aggravating genomic damage, such as copy number alterations, deletions or translocations.
“Recent studies have demonstrated the involvement of G4s in inducing or aggravating genomic damage, such as copy number alterations, deletions or translocations (65).”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [65]
The passages labeled Abstract contain bibliographic metadata and a ‘GENOME INSTABILITY’ keyword, but no discussion of G4s causing genomic damage. Searches for copy-number alterations, deletions, translocations, and chromosome rearrangements returned no substantive passage, so our copy cannot verify the claim. (LLM, conf=0.70)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Quadruplex DNA: sequence, topology and structure
Burge, S., Parkinson, G. N., Hazel, P., Todd, A. K., & Neidle, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl655 · Cited by 2,404 · see citing works
Quantitative visualization of DNA G-quadruplex structures in human cells
Biffi, G., Tannahill, D., McCafferty, J., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1548 · Cited by 2,152 · see citing works
Siddiqui-Jain, A., Grand, C., Bearss, D., & Hurley, L. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.182256799 · Cited by 2,069 · see citing works
G-quadruplexes and their regulatory roles in biology
Rhodes, D., & Lipps, H. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv862 · Cited by 1,494 · see citing works
DNA secondary structures: stability and function of G-quadruplex structures
Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,449 · see citing works
Self-citationHelix formation by guanylic acid.
Gellert, M., Lipsett, M., & Davies, D. R. (1962) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.48.12.2013 · Cited by 1,430 · see citing works
G-quadruplexes in promoters throughout the human genome
Huppert, J., & Balasubramanian, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl1057 · Cited by 1,287 · see citing works
High-throughput sequencing of DNA G-quadruplex structures in the human genome
Chambers, V. S., Marsico, G., Boutell, J. M., Antonio, M. D., Smith, G. P., & Balasubramanian, S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3295 · Cited by 1,238 · see citing works
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C. L., & de Lange, T. (2009) · Cell · doi:10.1016/j.cell.2009.06.021 · Cited by 990 · see citing works
G-quadruplex structures mark human regulatory chromatin
Hänsel-Hertsch, R., Beraldi, D., Lensing, S. V., Marsico, G., Zyner, K., Parry, A., Di Antonio, M., Pike, J., Kimura, H., Narita, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3662 · Cited by 964 · see citing works
G-quadruplex structures: in vivo evidence and function
Lipps, H. J., & Rhodes, D. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.05.002 · Cited by 829 · see citing works
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Wolfe, A. L., Singh, K., Zhong, Y., Drewe, P., Rajasekhar, V. K., Sanghvi, V. R., Mavrakis, K. J., Jiang, M., Roderick, J. E., Van der Meulen, J., et al. (2014) · Nature · doi:10.1038/nature13485 · Cited by 635 · see citing works
Schaffitzel, C., Berger, I., Postberg, J., Hanes, J., Lipps, H., & Plückthun, A. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.141229498 · Cited by 610 · see citing works
Biffi, G., Antonio, M. D., Tannahill, D., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1805 · Cited by 608 · see citing works
Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity
Crabbé, L., Verdún, R. E., Haggblom, C., & Karlseder, J. (2004) · Science · doi:10.1126/science.1103619 · Cited by 604 · see citing works
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
Mohaghegh, P. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2843 · Cited by 599 · see citing works
DNA tetraplex formation in the control region of c-myc
Simonsson, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1167 · Cited by 598 · see citing works
G-quadruplex nucleic acids as therapeutic targets
Balasubramanian, S., & Neidle, S. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.04.637 · Cited by 585 · see citing works
Paeschke, K., Capra, J. A., & Zakian, V. A. (2011) · Cell · doi:10.1016/j.cell.2011.04.015 · Cited by 566 · see citing works
Self-citationThe Bloom’s Syndrome Helicase Unwinds G4 DNA*
Sun, H., Karow, J. K., Hickson, I., & Maizels, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27587 · Cited by 552 · see citing works
Human telomeric G‐quadruplex: structures of DNA and RNA sequences
Phan, A. T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07464.x · Cited by 539 · see citing works
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
Paeschke, K., Simonsson, T., Postberg, J., Rhodes, D., & Lipps, H. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb982 · Cited by 531 · see citing works
Self-citationDuquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., & Maizels, N. (2004) · Genes & Development · doi:10.1101/gad.1200804 · Cited by 528 · see citing works
Gene function correlates with potential for G4 DNA formation in the human genome
Eddy, J., & Maizels, N. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl529 · Cited by 524 · see citing works
RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria
Guo, J. U., & Bartel, D. P. (2016) · Science · doi:10.1126/science.aaf5371 · Cited by 472 · see citing works
Pif1 family helicases suppress genome instability at G-quadruplex motifs
Paeschke, K., Bochman, M. L., Garcia, P. D., Ćejka, P., Friedman, K. L., Kowalczykowski, S. C., & Zakian, V. A. (2013) · Nature · doi:10.1038/nature12149 · Cited by 471 · see citing works
Self-citationRTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity
Vannier, J., Pavicic-Kaltenbrunner, V., Petalcorin, M. I. R., Ding, H., & Boulton, S. J. (2012) · Cell · doi:10.1016/j.cell.2012.03.030 · Cited by 462 · see citing works
G-quadruplex structures are stable and detectable in human genomic DNA
Lam, E. Y. N., Beraldi, D., Tannahill, D., & Balasubramanian, S. (2013) · Nature Communications · doi:10.1038/ncomms2792 · Cited by 455 · see citing works
Mendoza, Ó., Bourdoncle, A., Boulé, J.-B., Brosh, R. M., & Mergny, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw079 · Cited by 452 · see citing works
RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms
Fay, M. M., Lyons, S. M., & Ivanov, P. V. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.05.017 · Cited by 448 · see citing works
Law, M. J., Lower, K. M., Voon, H. P. J., Hughes, J. R., Garrick, D., Viprakasit, V., Mitson, M., Gobbi, M. D., Marra, M. A., Morris, A. P., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.023 · Cited by 443 · see citing works
G-quadruplexes: the beginning and end of UTRs
Huppert, J. L., Bugaut, A., Kumari, S., & Balasubramanian, S. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn511 · Cited by 432 · see citing works
Wu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02210-07 · Cited by 428 · see citing works
Polymorphism of human telomeric quadruplex structures
Dai, J., Carver, M., & Yang, D. (2008) · Biochimie · doi:10.1016/j.biochi.2008.02.026 · Cited by 418 · see citing works
Fry, M., & Loeb, L. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12797 · Cited by 371 · see citing works
RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination
Barber, L. J., Youds, J. L., Ward, J. D., McIlwraith, M. J., O'Neil, N. J., Petalcorin, M. I. R., Martin, J. S., Collis, S. J., Cantor, S. B., Auclair, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.08.016 · Cited by 369 · see citing works
Sun, D., & Hurley, L. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900055s · Cited by 367 · see citing works
Ribeyre, C., Lopes, J., Boulé, J., Piazza, A., Guédin, A., Zakian, V., Mergny, J., & Nicolas, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000475 · Cited by 367 · see citing works
Grand, C. L., Han, H., Muñoz, R. M., Weitman, S., Hoff, D. D. V., Hurley, L. H., & Bearss, D. J. (2002) · PubMed · Cited by 367 · see citing works
Existence and consequences of G-quadruplex structures in DNA
Murat, P., & Balasubramanian, S. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.10.012 · Cited by 346 · see citing works
G‐quadruplex‐induced instability during leading‐strand replication
Lopes, J., Piazza, A., Bermejo, R., Kriegsman, B. A., Colosio, A., Teulade‐Fichou, M., Foiani, M., & Nicolas, A. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.316 · Cited by 330 · see citing works
Regulation of Murine Telomere Length by Rtel
Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Kammori, M., Pourvali, R., Poon, S., Vulto, I., Chavez, E., et al. (2004) · Cell · doi:10.1016/j.cell.2004.05.026 · Cited by 309 · see citing works
Maizels, N. (2015) · EMBO Reports · doi:10.15252/embr.201540607 · Cited by 306 · see citing works
The RecQ DNA Helicases in DNA Repair
Bernstein, K. A., Gangloff, S., & Rothstein, R. J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102209-163602 · Cited by 297 · see citing works
Stabilization of G-Quadruplex DNA and Down-Regulation of Oncogene c-myc by Quindoline Derivatives
Ou, T., Lu, Y., Zhang, C., Huang, Z., Wang, X., Tan, J., Chen, Y., Ma, D., Wong, K., Tang, J. C. O., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0610088 · Cited by 289 · see citing works
Hershman, S. G., Chen, Q., Lee, J. Y., Kozak, M., Peng, Y., Wang, L., & Johnson, F. B. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm986 · Cited by 285 · see citing works
Capra, J. A., Paeschke, K., Singh, M., & Zakian, V. A. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000861 · Cited by 283 · see citing works
Self-citationDisruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA
Cheung, I. K., Schertzer, M. J., Rose, A. M., & Lansdorp, P. M. (2002) · Nature Genetics · doi:10.1038/ng928 · Cited by 270 · see citing works
Picketts, D. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.12.1899 · Cited by 260 · see citing works
FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
London, T. B. C., Barber, L. J., Mosedale, G., Kelly, G. P., Balasubramanian, S., Hickson, I. D., Boulton, S. J., & Hiom, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808152200 · Cited by 252 · see citing works
Structure, location and interactions of G‐quadruplexes
Huppert, J. L. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07758.x · Cited by 249 · see citing works
Chakraborty, P., & Große, F. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.04.013 · Cited by 248 · see citing works
DNA and RNA Quadruplex-Binding Proteins
Brázda, V., Hároníková, L., Liao, J. C. C., & Fojta, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017493 · Cited by 243 · see citing works
A comparison of DNA and RNA quadruplex structures and stabilities
Joachimi, A., Benz, A., & Hartig, J. S. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.08.043 · Cited by 232 · see citing works
Verma, A., Halder, K., Halder, R., Yadav, V. K., Rawal, P., Thakur, R. K., Mohd, F., Sharma, A., & Chowdhury, S. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800448a · Cited by 231 · see citing works
Michelotti, G. A., Michelotti, E., Pullner, A., Duncan, R. C., Eick, D., & Levens, D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2656 · Cited by 227 · see citing works
G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition
Huber, M. D. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf530 · Cited by 218 · see citing works
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
Sarkies, P., Murat, P., Phillips, L. G., Patel, K. J., Balasubramanian, S., & Sale, J. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr868 · Cited by 214 · see citing works
G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
Graybuck, L. T., Vallur, A. C., Eddy, J., & Maizels, N. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1475 · Cited by 211 · see citing works
Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans
Kruisselbrink, E., Guryev, V., Brouwer, K., Pontier, D. B., Cuppen, E., & Tijsterman, M. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.013 · Cited by 209 · see citing works
Unwinding the functions of the Pif1 family helicases
Bochman, M. L., Sabouri, N., & Zakian, V. A. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.008 · Cited by 209 · see citing works
Cusanelli, E., & Chartrand, P. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00143 · Cited by 208 · see citing works
Creacy, S. D., Routh, E. D., Iwamoto, F., Nagamine, Y., Akman, S. A., & Vaughn, J. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806277200 · Cited by 200 · see citing works
Telomeric repeat-containing RNA structure in living cells
Xu, Y., Suzuki, Y., Ito, K., & Komiyama, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001177107 · Cited by 193 · see citing works
Guen, T. L., Jullien, L., Touzot, F., Schertzer, M. J., Gaillard, L., Perderiset, M., Carpentier, W., Nitschké, P., Pïcard, C., Couillault, G., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt178 · Cited by 191 · see citing works
The biology of DHX9 and its potential as a therapeutic target
Lee, T., & Pelletier, J. (2016) · Oncotarget · doi:10.18632/oncotarget.8446 · Cited by 190 · see citing works
Zimmermann, M., Kibe, T., Kabir, S., & de Lange, T. (2014) · Genes & Development · doi:10.1101/gad.251611.114 · Cited by 189 · see citing works
Vaughn, J. P., Creacy, S. D., Routh, E. D., Joyner-Butt, C., Jenkins, G. S., Pauli, S., Nagamine, Y., & Akman, S. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500348200 · Cited by 187 · see citing works
Wanrooij, P. H., Uhler, J. P., Simonsson, T., Falkenberg, M., & Gustafsson, C. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006026107 · Cited by 184 · see citing works
Pause Sites Promote Transcriptional Termination of Mammalian RNA Polymerase II
Gromak, N., West, S., & Proudfoot, N. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3986-3996.2006 · Cited by 181 · see citing works
Barefield, C., & Karlseder, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks407 · Cited by 170 · see citing works
Agarwala, P., Pandey, S., & Maiti, S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob02681k · Cited by 168 · see citing works
Mammalian DNA2 helicase/nuclease cleaves G‐quadruplex DNA and is required for telomere integrity
Lin, W., Sampathi, S., Dai, H., Liu, C., Zhou, M., Hu, J., Huang, Q. M., Campbell, J. L., Shin‐ya, K., Zheng, L., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.88 · Cited by 166 · see citing works
BLM helicase facilitates telomere replication during leading strand synthesis of telomeres
Drosopoulos, W. C., Kosiyatrakul, S. T., & Schildkraut, C. L. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201410061 · Cited by 164 · see citing works
RecQ Helicases: Conserved Guardians of Genomic Integrity
Larsen, N. B., & Hickson, I. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5037-5_8 · Cited by 161 · see citing works
Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity
Sanders, C. M. (2010) · Biochemical Journal · doi:10.1042/bj20100612 · Cited by 156 · see citing works
Booy, E. P., Meier, M., Okun, N., Novakowski, S. K., Xiong, S., Stetefeld, J., & McKenna, S. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1306 · Cited by 155 · see citing works
FANCJ promotes DNA synthesis through G‐quadruplex structures
Bosch, P. C., Segura‐Bayona, S., Koole, W., Heteren, J. T. V., Dewar, J. M., Tijsterman, M., & Knipscheer, P. (2014) · The EMBO Journal · doi:10.15252/embj.201488663 · Cited by 154 · see citing works
Johnson, J. E., Cao, K.-J., Ryvkin, P., Wang, L.-S., & Johnson, F. B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1103 · Cited by 154 · see citing works
G-Quadruplexes in DNA Replication: A Problem or a Necessity?
Valton, A.-L., & Prioleau, M.-N. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.09.004 · Cited by 149 · see citing works
The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities
Popuri, V., Bachrati, C. Z., Muzzolini, L., Mosedale, G., Costantini, S., Giacomini, E., Hickson, I. D., & Vindigni, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709749200 · Cited by 147 · see citing works
Paeschke, K., Juranek, S., Simonsson, T., Hempel, A., Rhodes, D., & Lipps, H. J. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1422 · Cited by 141 · see citing works
Self-citationIdentification and characterization of RNA guanine-quadruplex binding proteins
von Hacht, A., Seifert, O., Menger, M., Schütze, T., Arora, A., Konthur, Z., Neubauer, P. B., Wagner, A., Weise, C., & Kurreck, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku290 · Cited by 141 · see citing works
Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation
Thangavel, S., Mendoza-Maldonado, R., Tissino, E., Sidorova, J. M., Yin, J., Wang, W., Monnat, R. J., Falaschi, A., & Vindigni, A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01290-09 · Cited by 139 · see citing works
Lattmann, S., Giri, B., Vaughn, J. P., Akman, S. A., & Nagamine, Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq372 · Cited by 138 · see citing works
Bharti, S. K., Sommers, J. A., George, F., Kuper, J., Hamon, F., Shin‐ya, K., Teulade‐Fichou, M., Kisker, C., & Brosh, R. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.496463 · Cited by 136 · see citing works
The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats
Nguyen, D. T. T., Voon, H. P. J., Xella, B., Scott, C., Clynes, D., Babbs, C., Ayyub, H., Kerry, J., Sharpe, J. A., Sloane‐Stanley, J., et al. (2017) · EMBO Reports · doi:10.15252/embr.201643078 · Cited by 134 · see citing works
Benhalevy, D., Gupta, S. K., Danan, C. H., Ghosal, S., Sun, H., Kazemier, H. G., Paeschke, K., Hafner, M., & Juranek, S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.080 · Cited by 133 · see citing works
Self-citationLiu, H., Zhao, Q., Zhang, T., Wu, Y., Xiong, Y., Wang, S., Ge, Y., He, J., Lv, P., Ou, T., et al. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.08.013 · Cited by 128 · see citing works
Nguyen, G. H., Tang, W., Robles, A. I., Beyer, R. P., Graybuck, L. T., Welsh, J. A., Schetter, A. J., Kumamoto, K., Wang, X. W., Hickson, I. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404807111 · Cited by 123 · see citing works
Specific Transcriptional Pausing Activates Polyadenylation in a Coupled In Vitro System
Yonaha, M., & Proudfoot, N. J. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80352-4 · Cited by 121 · see citing works
Lattmann, S., Stadler, M. B., Vaughn, J. P., Akman, S. A., & Nagamine, Y. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr630 · Cited by 120 · see citing works
Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K + Solution
Martadinata, H., & Phan, A. T. (2013) · Biochemistry · doi:10.1021/bi301606u · Cited by 117 · see citing works
Thandapani, P., Song, J., Gandin, V., Cai, Y., Rouleau, S. G., Garant, J., Boisvert, F., Yu, Z., Perreault, J., Topisirović, I., et al. (2015) · eLife · doi:10.7554/elife.06234 · Cited by 117 · see citing works
Recruitment of the RNA Helicase RHAU to Stress Granules via a Unique RNA-binding Domain
Chalupníková, K., Lattmann, S., Selak, N., Iwamoto, F., Fujiki, Y., & Nagamine, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804857200 · Cited by 117 · see citing works
Huang, W., Smaldino, P. J., Zhang, Q., Miller, L. D., Cao, P. D., Stadelman, K. M., Wan, M., Giri, B., Lei, M., Nagamine, Y., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr849 · Cited by 107 · see citing works
Human DDX21 binds and unwinds RNA guanine quadruplexes
McRae, E. K. S., Booy, E. P., Moya, A., Ezzati, P., Stetefeld, J., & McKenna, S. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx380 · Cited by 106 · see citing works
Structure, function and evolution of the XPD family of iron–sulfur-containing 5′→3′ DNA helicases
White, M. F. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370547 · Cited by 104 · see citing works
Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development
Nie, J., Jiang, M., Zhang, X., Tang, H., Jin, H., Huang, X., Yuan, B., Zhang, C., Lai, J. C., Nagamine, Y., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.043 · Cited by 87 · see citing works
Dynamics and stability of polymorphic human telomeric G-quadruplex under tension
You, H., Zeng, X., Xu, Y., Lim, C. J., Efremov, A. K., Phan, A. T., & Yan, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku581 · Cited by 86 · see citing works
The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1
Booy, E. P., Howard, R., Marushchak, O., Ariyo, E. O., Meier, M., Novakowski, S. K., Deo, S. R., Dzananovic, E., Stetefeld, J., & McKenna, S. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1340 · Cited by 81 · see citing works
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia
Brosh, R. M., & Cantor, S. B. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00372 · Cited by 77 · see citing works
DNA Replication Origins and Fork Progression at Mammalian Telomeres
Higa, M., Fujita, M., & Yoshida, K. (2017) · Genes · doi:10.3390/genes8040112 · Cited by 73 · see citing works
Sabouri, N., Capra, J. A., & Zakian, V. A. (2014) · BMC Biology · doi:10.1186/s12915-014-0101-5 · Cited by 72 · see citing works
Human Rev1 polymerase disrupts G-quadruplex DNA
Eddy, S., Ketkar, A., Zafar, M. K., Maddukuri, L., Choi, J.-Y., & Eoff, R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1314 · Cited by 71 · see citing works
Zheng, K., Wu, R., He, Y.-D., Xiao, S., Zhang, J., Liu, J., Hao, Y., & Tan, Z. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku764 · Cited by 70 · see citing works
Piazza, A., Serero, A., Boulé, J.-B., Legoix-Né, P., Lopes, J., & Nicolas, A. G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003033 · Cited by 68 · see citing works
Agarwal, T., Roy, S., Kumar, S., Chakraborty, T. K., & Maiti, S. (2014) · Biochemistry · doi:10.1021/bi401451q · Cited by 68 · see citing works
G‐Quadruplex Formation Interferes with P1 Helix Formation in the RNA Component of Telomerase hTERC
Gros, J., Guédin, A., Mergny, J., & Lacroix, L. (2008) · ChemBioChem · doi:10.1002/cbic.200800300 · Cited by 65 · see citing works
Wallgren, M., Mohammad, J. B., Yan, K., Pourbozorgi-Langroudi, P., Ebrahimi, M., & Sabouri, N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw349 · Cited by 64 · see citing works
A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase
Byrd, A. K., & Raney, K. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.630749 · Cited by 63 · see citing works
Nakken, S., Rognes, T., & Hovig, E. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp590 · Cited by 62 · see citing works
DNA Helicases and DNA Motor Proteins
Spies, M. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5037-5 · Cited by 61 · see citing works
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ–BLM helicase interaction
Suhasini, A. N., & Brosh, R. M. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.09.003 · Cited by 57 · see citing works
Newman, M., Sfaxi, R., Saha, A., Monchaud, D., Teulade‐Fichou, M., & Vagner, S. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.11.033 · Cited by 55 · see citing works
Wu, R., Zheng, K., Zhang, J., Hao, Y., & Tan, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201408719 · Cited by 54 · see citing works
Contributions of the specialised DNA polymerases to replication of structured DNA
Wickramasinghe, C. M., Arzouk, H., Frey, A., Maiter, A., & Sale, J. E. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.01.004 · Cited by 45 · see citing works
Multifunctional transcription factor YY1: a therapeutic target in human cancer?
Wang, C.-C., Chen, J. J. W., & Yang, P. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.2.253 · Cited by 45 · see citing works
Fekete, A., Kénesi, E., Hunyadi‐Gulyás, É., Dürgő, H., Berko, B., Dunai, Z. A., & Bauer, P. I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042690 · Cited by 45 · see citing works
A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase
Budhathoki, J. B., Maleki, P., Roy, W. A., Janščák, P., Yodh, J. G., & Balci, H. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.05.016 · Cited by 41 · see citing works
FANCJ: Solving problems in DNA replication
Hiom, K. J. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.005 · Cited by 40 · see citing works
Postberg, J., Tsytlonok, M., Sparvoli, D., Rhodes, D., & Lipps, H. J. (2012) · Gene · doi:10.1016/j.gene.2012.01.068 · Cited by 37 · see citing works
Replication of Structured DNA and its implication in epigenetic stability
Cea, V., Cipolla, L., & Sabbioneda, S. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00209 · Cited by 24 · see citing works
Biochemical Characterization of G4 Quadruplex Telomerase RNA Unwinding by the RNA Helicase RHAU
Booy, E. P., McRae, E. K. S., & McKenna, S. A. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-2214-7_9 · Cited by 21 · see citing works
Structure, Interactions and Effects on Activity of the 5′-terminal Region of Human telomerase RNA
Li, X., Nishizuka, H., Tsutsumi, K., Imai, Y., Kurihara, Y., & Uesugi, S. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvm081 · Cited by 19 · see citing works
Wanzek, K., Schwindt, E., Capra, J. A., & Paeschke, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx467 · Cited by 17 · see citing works
Self-citationMorphological Effects of G-Quadruplex Stabilization Using a Small Molecule in Zebrafish
Agarwal, T., Lalwani, M. K., Kumar, S., Roy, S., Chakraborty, T. K., Sivasubbu, S., & Maiti, S. (2014) · Biochemistry · doi:10.1021/bi4009352 · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 128 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Structure and Function of DNA G-Quadruplexes
Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920 · see citing works
G-quadruplexes: a promising target for cancer therapy
Kosiol, N., Juranek, S., Brossart, P., Heine, A., & Paeschke, K. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01328-4 · Cited by 540 · see citing works
Self-citationOn the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
Khristich, A. N., & Mirkin, S. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007678 · Cited by 289 · see citing works
Lago, S., Nadai, M., Cernilogar, F. M., Kazerani, M., Domíniguez Moreno, H., Schotta, G., & Richter, S. N. (2021) · Nature Communications · doi:10.1038/s41467-021-24198-2 · Cited by 269 · see citing works
Porphyrinoid biohybrid materials as an emerging toolbox for biomedical light management
Almeida‐Marrero, V., van de Winckel, E., Anaya‐Plaza, E., Torres⊗, T., & de la Escosura, A. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00554g · Cited by 216 · see citing works
Sauer, M., Juranek, S., Marks, J., Magis, A. D., Kazemier, H. G., Hilbig, D., Benhalevy, D., Wang, X., Hafner, M., & Paeschke, K. (2019) · Nature Communications · doi:10.1038/s41467-019-10432-5 · Cited by 180 · see citing works
Self-citationStructure and functional reselection of the Mango-III fluorogenic RNA aptamer
Trachman, R. J., Autour, A., Jeng, S. C. Y., Abdolahzadeh, A., Andreoni, A., Cojocaru, R., Garipov, R., Dolgosheina, E. V., Knutson, J. R., Ryckelynck, M., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0267-9 · Cited by 149 · see citing works
Liu, L., Liu, W., Wang, K., Zhu, B., Xia, X., Ji, L., & Mao, Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202002422 · Cited by 138 · see citing works
Zhi-yin, S., Wang, X., Cheng, S.-Q., Su, X., & Ou, T. (2019) · Molecules · doi:10.3390/molecules24030396 · Cited by 135 · see citing works
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Miglietta, G., Russo, M. V., & Capranico, G. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa944 · Cited by 135 · see citing works
Roychoudhury, S., Pramanik, S., Harris, H. L., Tarpley, M., Sarkar, A., Spagnol, G., Sorgen, P. L., Chowdhury, D., Band, V., Klinkebiel, D. L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912355117 · Cited by 127 · see citing works
G-Quadruplexes: More Than Just a Kink in Microbial Genomes
Saranathan, N., & Vivekanandan, P. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.08.011 · Cited by 110 · see citing works
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases
Zheng, L., Meng, Y., Campbell, J. L., & Shen, B. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1101 · Cited by 108 · see citing works
The emerging structural complexity of G-quadruplex RNAs
Banco, M. T., & Ferré-D’Amaré, A. R. (2021) · RNA · doi:10.1261/rna.078238.120 · Cited by 105 · see citing works
How to untie G-quadruplex knots and why?
Lejault, P., Mitteaux, J., Sperti, F. R., & Monchaud, D. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.01.015 · Cited by 96 · see citing works
G4-quadruplex-binding proteins: review and insights into selectivity
Meier-Stephenson, V. (2022) · Biophysical Reviews · doi:10.1007/s12551-022-00952-8 · Cited by 85 · see citing works
G-quadruplex in cancer biology and drug discovery
Nakanishi, C., & Seimiya, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.178 · Cited by 91 · see citing works
Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes
Bryan, T. M. (2019) · Molecules · doi:10.3390/molecules24193439 · Cited by 91 · see citing works
G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
Shu, H.-L., Zhang, R., Xiao, K., Yang, J., & Sun, X. (2022) · Biomolecules · doi:10.3390/biom12050648 · Cited by 78 · see citing works
Dahan, D., Tsirkas, I., Dovrat, D., Sparks, M. A., Singh, S. P., Galletto, R., & Aharoni, A. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1065 · Cited by 87 · see citing works
Shukla, V., Samaniego‐Castruita, D., Dong, Z., González‐Avalos, E., Yan, Q., Sarma, K., & Rao, A. (2021) · Nature Immunology · doi:10.1038/s41590-021-01087-w · Cited by 88 · see citing works
Tassinari, M., Richter, S. N., & Gandellini, P. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab127 · Cited by 82 · see citing works
Mammalian CST averts replication failure by preventing G-quadruplex accumulation
Zhang, M., Wang, B., Li, T., Liu, R., Xiao, Y., Geng, X., Li, G., Liu, Q., Price, C. M., Liu, Y., et al. (2018) · bioRxiv · doi:10.1093/nar/gkz264 · Cited by 78 · see citing works
Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons
Moruno-Manchon, J. F., Lejault, P., Wang, Y., McCauley, B. S., Honarpisheh, P., Morales‐Scheihing, D., Singh, S. S., Dang, W., Kim, N., Urayama, A., et al. (2020) · eLife · doi:10.7554/elife.52283 · Cited by 80 · see citing works
CNBP controls transcription by unfolding DNA G-quadruplex structures
David, A. P., Pipier, A., Pascutti, F., Binolfi, A., Weiner, A. M. J., Challier, E., Heckel, S., Calsou, P., Gómez, D., Calcaterra, N. B., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz527 · Cited by 80 · see citing works
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
Goodman, L. D., Prudencio, M., Kramer, N. J., Martinez-Ramirez, L. F., Srinivasan, A. R., Lan, M., Parisi, M. J., Zhu, Y., Chew, J., Cook, C. N., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0396-1 · Cited by 77 · see citing works
Human MYC G-quadruplex: From discovery to a cancer therapeutic target
Wang, W., Hu, S., Gu, Y., Yan, Y., Stovall, D. B., Li, D., & Sui, G. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188410 · Cited by 77 · see citing works
Crosstalk between G-quadruplex and ROS
Wu, S., Jiang, L., Lei, L., Fu, C., Huang, J., Hu, Y., Dong, Y., Chen, J., & Zeng, Q. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05562-0 · Cited by 69 · see citing works
“The unfolding and folding of G4s during replication or transcription are mainly catalyzed by helicases [54, 55] including DNA G4 helicases such as Pif1, ATRX, RecQ, FANCJ, BLM and WRN [54], and RNA G4 helicases such as DHX9, DHX36, and the DDX5/ DDX17/Dbp2 subfamily [56] (Fig.”
BackgroundThe Relevance of G-Quadruplexes for DNA Repair
Linke, R., Limmer, M., Juranek, S., Heine, A., & Paeschke, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212599 · Cited by 64 · see citing works
Self-citationG-quadruplex resolution: From molecular mechanisms to physiological relevance
Sato, K., & Knipscheer, P. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103552 · Cited by 64 · see citing works
DNA folds threaten genetic stability and can be leveraged for chemotherapy
Zell, J., Sperti, F. R., Britton, S., & Monchaud, D. (2020) · RSC Chemical Biology · doi:10.1039/d0cb00151a · Cited by 58 · see citing works
G-Quadruplexes and the DNA/RNA helicase DHX36 in health, disease, and aging
Antcliff, A., McCullough, L. D., & Tsvetkov, A. S. (2021) · Aging · doi:10.18632/aging.203738 · Cited by 58 · see citing works
Liu, L., Liu, W., Wang, K., Zhu, B., Xia, X., Ji, L., & Mao, Z. (2020) · Angewandte Chemie · doi:10.1002/ange.202002422 · Cited by 56 · see citing works
Targeting G-quadruplexes to achieve antiviral activity
Ruggiero, E., & Richter, S. N. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.129085 · Cited by 56 · see citing works
Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair
Magis, A. D., Götz, S., Hajikazemi, M., Fekete-Szücs, E., Caterino, M., Juranek, S., & Paeschke, K. (2020) · Nature Communications · doi:10.1038/s41467-020-17701-8 · Cited by 53 · see citing works
Self-citationFolding dynamics of polymorphic G‐quadruplex structures
Grün, J. T., & Schwalbe, H. (2021) · Biopolymers · doi:10.1002/bip.23477 · Cited by 52 · see citing works
Changing of the guard: How the Lyme disease spirochete subverts the host immune response
Chaconas, G., Castellanos, M., & Verhey, T. B. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.008583 · Cited by 50 · see citing works
Masai, H., & Tanaka, T. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.132 · Cited by 50 · see citing works
5′UTR G-quadruplex structure enhances translation in size dependent manner
Lee, C.-Y., Joshi, M., Wang, A. R., & Myong, S. (2024) · Nature Communications · doi:10.1038/s41467-024-48247-8 · Cited by 49 · see citing works
Recent advances in fluorescent probes for G-quadruplex nucleic acids
Yuan, J., Shao, W., Chen, S.-B., Huang, Z., & Tan, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.114 · Cited by 49 · see citing works
Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions
Byrd, A. K., Bell, M. R., & Raney, K. D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004499 · Cited by 46 · see citing works
Untangling the crosstalk between BRCA1 and R-loops during DNA repair
Alonso, M. S. M., & Noordermeer, S. M. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab178 · Cited by 45 · see citing works
Ligands stimulating antitumour immunity as the next G-quadruplex challenge
Miglietta, G., Marinello, J., Russo, M., & Capranico, G. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01649-y · Cited by 44 · see citing works
Folding Landscape of a Parallel G-Quadruplex
Gray, R. D., Trent, J. O., Arumugam, S., & Chaires, J. B. (2019) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.9b00227 · Cited by 44 · see citing works
Metal-Based G-Quadruplex Binders for Cancer Theranostics
Palma, E., Carvalho, J., Cruz, C., & Paulo, A. (2021) · Pharmaceuticals · doi:10.3390/ph14070605 · Cited by 44 · see citing works
The mechanism of replication stalling and recovery within repetitive DNA
Casas-Delucchi, C. S., Daza-Martín, M., Williams, S. L., & Coster, G. (2022) · Nature Communications · doi:10.1038/s41467-022-31657-x · Cited by 42 · see citing works
DNA helicases and their roles in cancer
Dhar, S., Datta, A., & Brosh, R. M. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102994 · Cited by 40 · see citing works
Yang, T., Li, J., Zhang, D., Cheng, X., Li, J., Huang, X., Ding, S., Tang, B. Z., & Cheng, W. (2022) · ACS Sensors · doi:10.1021/acssensors.2c01391 · Cited by 40 · see citing works
Frasson, I., Soldà, P., Nadai, M., Lago, S., & Richter, S. N. (2021) · Communications Biology · doi:10.1038/s42003-021-02035-y · Cited by 37 · see citing works
Cation-Responsive and Photocleavable Hydrogels from Noncanonical Amphiphilic DNA Nanostructures
Fabrini, G., Minard, A., Brady, R. A., Antonio, M. D., & Michele, L. D. (2022) · Nano Letters · doi:10.1021/acs.nanolett.1c03314 · Cited by 35 · see citing works
Paul, T., Voter, A. F., Cueny, R. R., Gavrilov, M. M., Ha, T., Keck, J. L., & Myong, S. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa442 · Cited by 34 · see citing works
Duplex-tetraplex equilibria in guanine- and cytosine-rich DNA
Chalikian, T. V., Liu, L., & Macgregor, R. B. (2020) · Biophysical Chemistry · doi:10.1016/j.bpc.2020.106473 · Cited by 34 · see citing works
Constrained G4 structures unveil topology specificity of known and new G4 binding proteins
Pipier, A., Devaux, A., Lavergne, T., Adrait, A., Couté, Y., Britton, S., Calsou, P., Riou, J., Defrancq, É., & Gómez, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-92806-8 · Cited by 34 · see citing works
DNA G‐Quadruplexes (G4s) Modulate Epigenetic (Re)Programming and Chromatin Remodeling
Varizhuk, A. M., Isaakova, E. A., & Pozmogova, G. E. (2019) · BioEssays · doi:10.1002/bies.201900091 · Cited by 33 · see citing works
Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control
Taylor, K., & Sobczak, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145161 · Cited by 32 · see citing works
Action and function of helicases on RNA G-quadruplexes
Caterino, M., & Paeschke, K. (2021) · Methods · doi:10.1016/j.ymeth.2021.09.003 · Cited by 32 · see citing works
Self-citationWang, L., Wang, Q.-M., Wang, Y.-R., Xi, X., & Hou, X. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005071 · Cited by 31 · see citing works
Regulation of autophagy by DNA G-quadruplexes
Lejault, P., Moruno-Manchon, J. F., Vemu, S. M., Honarpisheh, P., Zhu, L., Kim, N., Urayama, A., Monchaud, D., McCullough, L. D., & Tsvetkov, A. S. (2020) · Autophagy · doi:10.1080/15548627.2020.1769991 · Cited by 31 · see citing works
G-quadruplexes and associated proteins in aging and Alzheimer’s disease
Kumar, M. J. V., Morales, R., & Tsvetkov, A. S. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1164057 · Cited by 33 · see citing works
Dorn, A., Feller, L., Castri, D., Röhrig, S., Enderle, J., Herrmann, N. J., Block-Schmidt, A. S., Trapp, O., Köhler, L., & Puchta, H. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008174 · Cited by 30 · see citing works
Zhang, X., Yu, L., Ye, S., Xie, J., Huang, X., Zheng, K., & Sun, B. (2019) · iScience · doi:10.1016/j.isci.2019.06.016 · Cited by 29 · see citing works
RPA and Pif1 cooperate to remove G-rich structures at both leading and lagging strand
Maestroni, L., Audry, J., Luciano, P., Coulon, S., Géli, V., & Corda, Y. (2020) · Cell Stress · doi:10.15698/cst2020.03.214 · Cited by 29 · see citing works
SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase
Martone, J., Mariani, D., Santini, T., Setti, A., Shamloo, S., Colantoni, A., Capparelli, F., Paiardini, A., Dimartino, D., Morlando, M., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949942 · Cited by 29 · see citing works
Non-canonical DNA in human and other ape telomere-to-telomere genomes
Smeds, L., Kamali, K., Kejnovská, I., Kejnovský, E., Chiaromonte, F., & Makova, K. D. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf298 · Cited by 28 · see citing works
The Functional Consequences of Eukaryotic Topoisomerase 1 Interaction with G-Quadruplex DNA
Berroyer, A., & Kim, N. (2020) · Genes · doi:10.3390/genes11020193 · Cited by 27 · see citing works
Fundamentals of G-quadruplex biology
Johnson, F. B. (2020) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2020.06.004 · Cited by 27 · see citing works
Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma
Akter, J., Katai, Y., Parvin, S., Takenobu, H., Haruta, M., Sugino, R. P., Mukae, K., Satoh, S., Wada, T., Ohira, M., et al. (2021) · Oncogenesis · doi:10.1038/s41389-021-00363-6 · Cited by 27 · see citing works
G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology
Datta, A., Pollock, K. J., Kormuth, K. A., & Brosh, R. M. (2021) · Cytogenetic and Genome Research · doi:10.1159/000516394 · Cited by 26 · see citing works
Simple Repeats as Building Blocks for Genetic Computers
Herbert, A. G. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.06.012 · Cited by 24 · see citing works
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
Schult, P., & Paeschke, K. (2020) · Biological Chemistry · doi:10.1515/hsz-2020-0292 · Cited by 25 · see citing works
Self-citationUV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence
Magis, A. D., Limmer, M., Mudiyam, V., Monchaud, D., Juranek, S., & Paeschke, K. (2023) · Nature Communications · doi:10.1038/s41467-023-42494-x · Cited by 23 · see citing works
Self-citationStructural overview of DNA and RNA G-quadruplexes in their interaction with proteins
Troisi, R., & Sica, F. (2024) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2024.102846 · Cited by 24 · see citing works
Orren, D. K., & Machwe, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158300 · Cited by 24 · see citing works
Higher Order Organization of the mtDNA: Beyond Mitochondrial Transcription Factor A
Mishmar, D., Levin, R., Naeem, M. M., & Sondheimer, N. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01285 · Cited by 24 · see citing works
Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization
Tabor, N., Ngwa, C., Mitteaux, J., Meyer, M. D., Moruno-Manchon, J. F., Zhu, L., Liu, F., Monchaud, D., McCullough, L. D., & Tsvetkov, A. S. (2021) · Aging · doi:10.18632/aging.203222 · Cited by 24 · see citing works
RNA helicases required for viral propagation in humans
Marecki, J. C., Belachew, B., Gao, J., & Raney, K. D. (2021) · The Enzymes · doi:10.1016/bs.enz.2021.09.005 · Cited by 23 · see citing works
Heddi, B., Cheong, V. V., Schmitt, E., Méchulam, Y., & Phan, A. T. (2019) · Journal of Structural Biology · doi:10.1016/j.jsb.2019.10.001 · Cited by 23 · see citing works
Saczuk, K., Cottini, M. V., Dudek, M., Mazur, L. M., Sánchez, D. P., López‐Pacios, L., Kassem, A., Matczyszyn, K., Nogueira, J. J., Monnereau, C., et al. (2025) · Nanoscale Horizons · doi:10.1039/d5nh00237k · Cited by 22 · see citing works
Wang, Y.-R., Guo, T., Zheng, Y., Lai, C.-W., Sun, B., Xi, X., & Hou, X. (2021) · iScience · doi:10.1016/j.isci.2021.102493 · Cited by 22 · see citing works
Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase
Maleki, P., Mustafa, G., Gyawali, P., Budhathoki, J. B., Ma, Y., Nagasawa, K., & Balci, H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz803 · Cited by 22 · see citing works
Al‐Zeer, M. A., Dutkiewicz, M., von Hacht, A., Kreuzmann, D., Röhrs, V., & Kurreck, J. (2019) · RNA Biology · doi:10.1080/15476286.2019.1652524 · Cited by 21 · see citing works
Ruggiero, E., Frasson, I., Tosoni, E., Scalabrin, M., Perrone, R., Marušič, M., Plavec, J., & Richter, S. N. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00508 · Cited by 21 · see citing works
Benabou, S., Mazzini, S., Aviñó, A. M., Eritja, R., & Gargallo, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-52311-5 · Cited by 21 · see citing works
G-quadruplex-mediated genomic instability drives SNVs in cancer
Richl, T., Kuper, J., & Kisker, C. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae098 · Cited by 20 · see citing works
DNA G-Quadruplex-Binding Proteins: An Updated Overview
Sánchez-Martín, V. (2023) · DNA · doi:10.3390/dna3010001 · Cited by 20 · see citing works
Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role
Anastasakis, D. G., Apostolidi, M., Garman, K. A., Polash, A. H., Umar, M. I., Meng, Q., Scutenaire, J., Jarvis, J. E., Wang, X., Haase, A. D. D., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.07.025 · Cited by 20 · see citing works
Kinetics, conformation, stability, and targeting of G-quadruplexes from a physiological perspective
Tan, Z., Hao, Y., & Zheng, K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.047 · Cited by 20 · see citing works
G-quadruplex in animal development: Contribution to gene expression and genomic heterogeneity
Armas, P., & Calcaterra, N. B. (2018) · Mechanisms of Development · doi:10.1016/j.mod.2018.05.004 · Cited by 19 · see citing works
Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy
Oh, K., Kim, J., Park, C., & Lee, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082673 · Cited by 19 · see citing works
A Novel G-Quadruplex Binding Protein in Yeast—Slx9
Götz, S., Pandey, S., Bartsch, S., Juranek, S., & Paeschke, K. (2019) · Molecules · doi:10.3390/molecules24091774 · Cited by 18 · see citing works
Self-citationMerlino, F., Marzano, S., Zizza, P., D’Aria, F., Grasso, N., Carachino, A., Iachettini, S., Biroccio, A., Fonzo, S. D., Grieco, P., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae471 · Cited by 18 · see citing works
G-quadruplexes in the BAP1 promoter positively regulate its expression
Li, Y., Zhang, X., Gao, Y., Shi, J., Tang, L., & Sui, G. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.05.016 · Cited by 18 · see citing works
New Roles for Canonical Transcription Factors in Repeat Expansion Diseases
Goodman, L. D., & Bonini, N. M. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.11.003 · Cited by 18 · see citing works
Shitikov, E. A., Bespiatykh, D., Malakhova, M. V., Bespyatykh, J., Bodoev, I. N., Vedekhina, T., Zaychikova, M. V., Veselovsky, V. A., Klimina, K. M., Ilina, E. N., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.817024 · Cited by 18 · see citing works
Ganegamage, S. K., & Heagy, M. D. (2022) · Current Organic Chemistry · doi:10.2174/1385272826666220811102939 · Cited by 17 · see citing works
Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin
Escarcega, R. D., Patil, A. A., Moruno-Manchon, J. F., Urayama, A., Marrelli, S. P., Kim, N., Monchaud, D., McCullough, L. D., & Tsvetkov, A. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105157 · Cited by 16 · see citing works
Centromere: A Trojan horse for genome stability
Scelfo, A., & Fachinetti, D. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103569 · Cited by 16 · see citing works
Herbert, A. G. (2022) · BioEssays · doi:10.1002/bies.202200166 · Cited by 15 · see citing works
HNRNPU's multi‐tasking is essential for proper cortical development
Sapir, T., & Reiner, O. (2023) · BioEssays · doi:10.1002/bies.202300039 · Cited by 14 · see citing works
Fu, L., Wu, Q., & Fu, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131811 · Cited by 15 · see citing works
- Authors
- Sauer, M., & Paeschke, K.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Paeschke, Katrin
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2017-09-22
- Volume
- 45
- Issue
- 5
- Pages
- 1173-1182
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2757691983
- Cited by
- 179
- References
- 128
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 30 · 2023: 13 · 2022: 18 · 2021: 27 · 2020: 32 · 2019: 21 · 2018: 10 · 2017: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- other-oa
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- G-quadruplex, DNA structure, genomic instability, telomere maintenance, DNA replication, transcription, translation (biology), in vivo function
- MeSH terms
- Animals, DNA, DNA Replication, DNA Helicases, Humans, RNA, Messenger, Transcription, Genetic, G-Quadruplexes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review