Cited by 181DNA and Nucleic Acid ChemistryTelomeres, Telomerase, and SenescenceDNA Repair Mechanisms

G-quadruplex unwinding helicases and their function in vivo

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Sauer, Markus, Paeschke, Katrin·2017·Biochemical Society Transactions

Abstract

The concept that G-quadruplex (G4) structures can form within DNA or RNA in vitro has been long known and extensively discussed. In recent years, accumulating evidences imply that G-quadruplex structures form in vivo. Initially, inefficient regulation of G-quadruplex structures was mainly associated with genome instability. However, due to the location of G-quadruplex motifs and their evolutionary conservation, different cellular functions of these structures have been postulated (e.g. in telomere maintenance, DNA replication, transcription, and translation). Regardless of their function, efficient and controlled formation and unwinding are very important, because ‘mis’-regulated G-quadruplex structures are detrimental for a given process, causing genome instability and diseases. Several helicases have been shown to target and regulate specific G-quadruplex structures. This mini-review focuses on the biological consequences of G4 disruption by different helicases in vivo.

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  • Recent studies have demonstrated the involvement of G4s in inducing or aggravating genomic damage, such as copy number alterations, deletions or translocations.

    “Recent studies have demonstrated the involvement of G4s in inducing or aggravating genomic damage, such as copy number alterations, deletions or translocations (65).”

    From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [65]

    The passages labeled Abstract contain bibliographic metadata and a ‘GENOME INSTABILITY’ keyword, but no discussion of G4s causing genomic damage. Searches for copy-number alterations, deletions, translocations, and chromosome rearrangements returned no substantive passage, so our copy cannot verify the claim. (LLM, conf=0.70)

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Authors
Sauer, M., & Paeschke, K.
Affiliations
University Medical Center Groningen (NL)
Corresponding author
Paeschke, Katrin
Venue
Biochemical Society Transactions
Published
2017-09-22
Volume
45
Issue
5
Pages
1173-1182
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
OpenAlex
W2757691983
Cited by
179
References
128
Citations by year
2026: 9 · 2025: 16 · 2024: 30 · 2023: 13 · 2022: 18 · 2021: 27 · 2020: 32 · 2019: 21 · 2018: 10 · 2017: 3
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Biochemical Society Transactions (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
G-quadruplex, DNA structure, genomic instability, telomere maintenance, DNA replication, transcription, translation (biology), in vivo function
MeSH terms
Animals, DNA, DNA Replication, DNA Helicases, Humans, RNA, Messenger, Transcription, Genetic, G-Quadruplexes

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