GeneCaRNA: A Comprehensive Gene-centric Database of Human Non-coding RNAs in the GeneCards Suite.
Open accessAbstract
Non-coding RNA (ncRNA) genes assume increasing biological importance, with growing associations with diseases. Many ncRNA sources are transcript-centric, but for non-coding variant analysis and disease decipherment it is essential to transform this information into a comprehensive set of genome-mapped ncRNA genes. We present GeneCaRNA, a new all-inclusive gene-centric ncRNA database within the GeneCards Suite. GeneCaRNA information is integrated from four community-backed data structures: the major transcript database RNAcentral with its 20 encompassed databases, and the ncRNA entries of three major gene resources HGNC, Ensembl and NCBI Gene. GeneCaRNA presents 219,587 ncRNA gene pages, a 7-fold increase from those available in our three gene mining sources. Each ncRNA gene has wide-ranging annotation, mined from >100 worldwide sources, providing a powerful GeneCards-leveraged search. The latter empowers VarElect, our disease-gene interpretation tool, allowing one to systematically decipher ncRNA variants. The combined power of GeneCaRNA with GeneHancer, our regulatory elements database, facilitates wide-ranging scrutiny of the non-coding terra incognita of gene networks and whole genome analyses.
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- Authors
- Barshir, R., Fishilevich, S., Iny-Stein, T., Zelig, O., Mazor, Y., Guan-Golan, Y., Safran, M., & Lancet, D.
- Affiliations
- Weizmann Institute of Science (IL)
- Alameda Applied Sciences Corporation (United States) (US)
- Corresponding author
- Barshir, Ruth
- Lancet, Doron
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 433
- Issue
- 11
- Pages
- 166913
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W3135817634
- Cited by
- 134
- References
- 39
- Citations by year
- 2026: 27 · 2025: 32 · 2024: 28 · 2023: 30 · 2022: 14 · 2021: 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Molecular Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- non-coding RNA, GeneCards, non-coding variants, regulatory elements, human genome
- MeSH terms
- Genes, Humans, Software, Genetic Predisposition to Disease, RNA, Untranslated, Databases, Nucleic Acid, Gene Regulatory Networks
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