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Patient-derived organoids (PDOs) and PDO-derived xenografts (PDOXs): New opportunities in establishing faithful pre-clinical cancer models

Wang, Ergang, Xiang, Kun, Zhang, Yun, Wang, Xiao-Fan·2022·Journal of the National Cancer Center
DOI 10.1016/j.jncc.2022.10.001PMC PMC11256726
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Fig. 1 Comparison of patient-derived organoids (PDO), patient-derived xenografts (PDX) and PDO-derived xenografts (PDOX), along with a potential workflow for deriving patient-derived models of cancer (PDMC) in the future.
Fig. 1 Comparison of patient-derived organoids (PDO), patient-derived xenografts (PDX) and PDO-derived xenografts (PDOX), along with a potential workflow for deriving patient-derived models of cancer (PDMC) in the future.CC BY · PubMed Central
Fig. 2 Summary of advanced models of PDO and their applications. Inner loop: advanced PDO models. Outer loop: popular applications of PDO. ECM, extracellular matrix; FNB, fine-needle biopsy; TME, tumor microenvironment.
Fig. 2 Summary of advanced models of PDO and their applications. Inner loop: advanced PDO models. Outer loop: popular applications of PDO. ECM, extracellular matrix; FNB, fine-needle biopsy; TME, tumor microenvironment.CC BY · PubMed Central

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Metadata

Authors
Wang, E., Xiang, K., Zhang, Y., & Wang, X.-F.
Venue
Journal of the National Cancer Center
Publisher
Elsevier BV
Published
2022-12
Volume
2
Issue
4
Pages
263-276
ISSN
2667-0054
DOI
10.1016/j.jncc.2022.10.001
PMC
PMC11256726
Cited by
56
References
37
Language
en
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