Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer
Open accessAbstract
Accumulating evidence indicates that patient-derived organoids (PDOs) can predict drug responses in the clinic, but the ability of PDOs to predict responses to chemoradiation in cancer patients remains an open question. Here we generate a living organoid biobank from patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiation (NACR) enrolled in a phase III clinical trial. Our co-clinical trial data confirm that rectal cancer organoids (RCOs) closely recapitulate the pathophysiology and genetic changes of corresponding tumors. Chemoradiation responses in patients are highly matched to RCO responses, with 84.43% accuracy, 78.01% sensitivity, and 91.97% specificity. These data imply that PDOs predict LARC patient responses in the clinic and may represent a companion diagnostic tool in rectal cancer treatment.
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Patient-derived tumoroid models show promise in testing drug efficacy and potentially determining a personalized treatment for the patient.
“patient-derived tumoroid models also show promise in testing drug efficacy and potentially determining a personalized treatment for the patient7–12.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [12]
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BackgroundOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
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- Authors
- Yao, Y., Xu, X., Yang, L., Zhu, J., Wan, J., Shen, L., Xia, F., Fu, G., Deng, Y., Pan, M., Guo, Q., Gao, X., Li, Y., Rao, X., Zhou, Y., Liang, L., Wang, Y., Zhang, J., Zhang, H., Li, G., Zhang, L., Peng, J., Cai, S., Hu, C., Gao, J., Clevers, H., Zhang, Z., & Hua, G.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Johns Hopkins University (US)
- University Medical Center Utrecht (NL)
- Corresponding author
- Zhang, Zhen
- Hua, Guoqiang
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 26
- Issue
- 1
- Pages
- 17-26.e6
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2994559322
- Cited by
- 755
- References
- 15
- Citations by year
- 2026: 107 · 2025: 115 · 2024: 135 · 2023: 115 · 2022: 118 · 2021: 113 · 2020: 49 · 2019: 1
- FWCI
- 29.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- patient-derived organoids, rectal cancer, locally advanced rectal cancer, neoadjuvant chemoradiotherapy, organoid biobank, companion diagnostics, predictive biomarkers
- MeSH terms
- Humans, Organoids, Rectal Neoplasms, Neoadjuvant Therapy, Chemoradiotherapy
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