Twenty-four-hour rhythms of mitogenic responses, lymphocyte subset populations and amino acid content in submaxillary lymph nodes of growing male rats subjected to calorie restriction
Abstract
Peripubertal male Wistar rats were submitted to a calorie restriction diet enriched in proteins and low in fat and carbohydrates for 4 weeks, and starting on day 35 of life. Mitogenic responses, lymphocyte subset populations, interferon (IFN)- gamma release and amino acid content were determined in submaxillary lymph nodes at six time intervals during the 24-h span. The diet employed completely arrested growth in growing rats. After caloric restriction, mean values of Con A response, lymph node T and CD4+ cell number and CD4+/CD8+ ratio augmented, whereas those of B cell number, IFN-gamma release and glutamine and glutamate concentration decreased. Calorie restriction modified 24-h rhythmicity of lymph node mitogenic responses to Con A and LPS, and of T, T-B, CD4+ and CD4+ -CD8+ lymph node cell subsets. It also changed the 24-h pattern of lymph node IFN-gamma release and glutamine, aspartate, glutamate and taurine lymph node content. Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of immune responsiveness in growing rats.
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In the rat model of human African trypanosomiasis, sleep alterations, including circadian sleep-wake disruption, sleep fragmentation, and decreased REM sleep latency, start early after infection and become increasingly severe at the time of neuroinvasion of the parasite.
“In the rat model of HAT, it has been reported that sleep alterations, including circadian sleep-wake disruption, sleep fragmentation, and decreased REM sleep latency, start early after infection and become increasingly severe at the time of neuroinvasion of the parasite (170).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [170]
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“Indeed, the studies described in section IIIA showing a sleep-induced reduction in circulating lymphocyte numbers, together with other studies suggesting an accumulation of APCs and lymphocytes in lymphatic tissues during the rest phase, support this notion (63, 67, 143, 148, 169).”
BackgroundResultCrosstalk between the circadian clock circuitry and the immune system
Cermakian, N., Lange, T., Golombek, D., Sarkar, D., Nakao, A., Shibata, S., & Mazzoccoli, G. (2013) · Chronobiology International · doi:10.3109/07420528.2013.782315 · Cited by 279 · see citing works
- Authors
- Esquifino, A. I., Chacon, F., Cano, P., Marcos, A., Cutrera, R. A., & Cardinali, D. P.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de Buenos Aires (AR)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 156
- Issue
- 1-2
- Pages
- 66-73
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2025205543
- Cited by
- 26
- References
- 28
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 4
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Danone
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- caloric restriction, circadian rhythm, immune responsiveness, mitogen response, concanavalin A, lipopolysaccharide, lymphocyte subsets, CD4/CD8 ratio, interferon-gamma, amino acid content, glutamine, glutamate, taurine, aspartic acid, T cells, B cells, growth arrest, peripubertal rats
- MeSH terms
- Aging, Amino Acids, Animals, Circadian Rhythm, Interferon-gamma, Lymph Nodes, Male, Mitogens, Submandibular Gland, Lymphocyte Subsets, Rats, Wistar, Caloric Restriction, Rats
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