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Cited by 87Obsessive-Compulsive Spectrum DisordersAutoimmune Neurological Disorders and TreatmentsStreptococcal Infections and Treatments

Maternal history of autoimmune disease in children presenting with tics and/or obsessive-compulsive disorder

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Murphy, T.K., Storch, E.A., Turner, A., Reid, J.M., Tan, J., Lewin, A.B.·2010·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2010.08.017PMC PMC2991439
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Abstract

Objectives A commonality across a number of pediatric neuropsychiatric disorders is a higher than typical rate of familial - and especially maternal - autoimmune disease. Of recent interest, a subtype of obsessive-compulsive disorder (OCD) and tic disorders known collectively as Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) is believed to be secondary to central nervous system (CNS) autoimmunity that occurs in relation to group A streptococcal infection. Thus, we hypothesized that a sample of children with OCD and/or tics would have an increased maternal risk for an autoimmune response relative to population norms. We also expected maternal prevalence of various autoimmune diseases to be higher among those participants that met the putative criteria for PANDAS.Methods We examined, via structured interview, the medical history of the biological mothers of 107 children with OCD and/or tics.Results Autoimmune disorders were reported in 17.8% of study mothers, which is significantly greater than the general prevalence among women in the United States (approximately 5%). Further, study mothers were more likely to report having an autoimmune disease if their children were considered "likely PANDAS" cases versus "unlikely PANDAS" cases.Conclusions The results offer preliminary support for hypothesized links between maternal autoimmune disease and both OCD/tics and PANDAS in youth. Further research is necessary to clarify these general associations; links to specific autoimmune disease; and relevance of autoimmune disease in other family members (e.g., fathers).

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  • Multiple studies have linked maternal conditions before and during pregnancy, such as maternal smoking and maternal history of autoimmune disease, to the risk of OCD.

    “Indeed, multiple studies have linked maternal conditions before and during pregnancy, such as maternal smoking and maternal history of autoimmune disease, to the risk of OCD (16,25).”

    From Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder (2020) · cites this paper as [25]

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Authors
Murphy, T. K., Storch, E. A., Turner, A., Reid, J. M., Tan, J., & Lewin, A. B.
Affiliations
University of South Florida (US)
Corresponding author
Murphy, T.K.
ORCID
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2010-12
Volume
229
Issue
1-2
Pages
243-247
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/j.jneuroim.2010.08.017
PMC
PMC2991439
OpenAlex
W2086758012
Cited by
87
References
42
Citations by year
2026: 3 · 2025: 2 · 2024: 9 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 3
FWCI
3.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (K23MH001739, R01MH063914)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
Keywords
PANDAS, pediatric autoimmune neuropsychiatric disorders, maternal autoimmune disease, obsessive-compulsive disorder, tic disorders, group A streptococcal infection, central nervous system autoimmunity, children
MeSH terms
Adolescent, Adult, Autoimmune Diseases, Child, Child, Preschool, Female, Humans, Male, Mothers, Obsessive-Compulsive Disorder, Risk, Prevalence, Genetic Predisposition to Disease, Tics

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