Cited by 153Obsessive-Compulsive Spectrum DisordersPsychosomatic Disorders and Their TreatmentsPsychoanalysis and Psychopathology Research

A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders

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Mataix-Cols, D, Frans, E, Pérez-Vigil, A, Kuja-Halkola, R, Gromark, C, Isomura, K, Fernández de la Cruz, L, Serlachius, E +6 more·2018·Molecular Psychiatry

Abstract

The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013. The risk of 40 ADs was evaluated in individuals with OCD, individuals with TD/CTD and their first- (siblings, mothers, fathers), second- (half siblings) and third-degree (cousins) relatives, compared with population controls. Individuals with OCD and TD/CTD had increased comorbidity with any AD (43% and 36%, respectively) and many individual ADs. The risk of any AD and several individual ADs was consistently higher among first-degree relatives than among second- and third-degree relatives of OCD and TD/CTD probands. The risk of ADs was very similar in mothers, fathers and siblings of OCD probands, whereas it tended to be higher in mothers and fathers of TD/CTD probands (compared with siblings). The results suggest a familial link between ADs in general (that is, not limited to Streptococcus-related conditions) and both OCD and TD/CTD. Additional mother-specific factors, such as the placental transmission of antibodies, cannot be fully ruled out, particularly in TD/CTD.

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  • Maternal factors have been shown to increase risk for multiple psychiatric phenotypes in offspring.

    “Interestingly, maternal factors have been shown to increase risk for multiple psychiatric phenotypes in offspring [see, for example, (26–33)].”

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Authors
Mataix-Cols, D., Frans, E., Pérez-Vigil, A., Kuja-Halkola, R., Gromark, C., Isomura, K., Fernández de la Cruz, L., Serlachius, E., Leckman, J. F., Crowley, J. J., Rück, C., Almqvist, C., Lichtenstein, P., & Larsson, H.
Affiliations
  • Karolinska Institutet (SE)
  • Region Stockholm (SE)
  • Yale University (US)
  • University of North Carolina at Chapel Hill (US)
  • Karolinska University Hospital (SE)
  • Örebro University (SE)
Venue
Molecular Psychiatry
Published
2017-11-14
Volume
23
Issue
7
Pages
1652-1658
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2770065591
Cited by
153
References
41
Citations by year
2026: 13 · 2025: 17 · 2024: 17 · 2023: 19 · 2022: 31 · 2021: 22 · 2020: 7 · 2019: 19 · 2018: 7 · 2012: 1
FWCI
11.08
Type
journal article
Language
en
Open access
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Open Archive (Karolinska Institutet) (submittedVersion)
  • UNC Libraries
Funders
  • Syracuse University
  • State University of New York
  • Fundación Alicia Koplowitz
  • Tourette Association of America
  • Hjärnfonden
  • Shire
  • Vetenskapsrådet
  • Forskningsrådet om Hälsa, Arbetsliv och Välfärd
  • National Institutes of Health
  • State University of New York Upstate Medical University
  • National Institute of Mental Health (R01MH110427, R01MH105500, R21MH112963)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
obsessive-compulsive disorder, Tourette syndrome, chronic tic disorders, autoimmune disease, familial aggregation, comorbidities, genetic risk, first-degree relatives, placental transfer, birth cohort
MeSH terms
Adolescent, Adult, Aged, Autoimmune Diseases, Child, Family, Female, Tourette Syndrome, Humans, Male, Obsessive-Compulsive Disorder, Pedigree, Risk Factors, Sweden, Tic Disorders, Comorbidity, Cluster Analysis, Case-Control Studies, Siblings

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