Cited by 55Neuroinflammation and Neurodegeneration MechanismsThermal Regulation in MedicineStress Responses and Cortisol

Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain

Sugama, Shuei, Takenouchi, Takato, Fujita, Masayo, Kitani, Hiroshi, Hashimoto, Makoto·2011·Journal of Neuroimmunology

Abstract

The present study investigated the possible impact of cold stress on the immune functions of the brain. Wistar rats were exposed to 4°C for 2h prior to analysis of immunohistochemical analysis of OX-42 and IL-1β, which are markers of microglia and inflammation, respectively. Exposure to cold stress induced morphological microglial activation in as early as 30 min, and the activation lasted up to 2h following the stress. In addition, increased IL-1β-immunoreactivity was detected in the hippocampus and hypothalamus. However, IL-1β was not co-localized with microglia, and was predominantly expressed in astroglia. The present study provides the first evidence that cold stress contributes to neuro-immunomodulation in the brain through microglial activation and expression of IL-1β in astroglia.

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Crossref · 10.1016/j.jneuroim.2010.11.002

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Authors
Sugama, S., Takenouchi, T., Fujita, M., Kitani, H., & Hashimoto, M.
Affiliations
  • Nippon Medical School (JP)
  • Institute of Agrobiological Sciences (JP)
Corresponding author
Sugama, Shuei
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2011-04
Volume
233
Issue
1-2
Pages
29-36
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2121667809
Cited by
55
References
39
Citations by year
2026: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 4
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
cold stress, microglial activation, IL-1β, astroglial cells, neuroinflammation, hippocampus, hypothalamus, OX-42, cold exposure
MeSH terms
Animals, Brain, Cold Temperature, Disease Models, Animal, Gliosis, Male, Stress, Physiological, Neuroimmunomodulation, Up-Regulation, Rats, Wistar, Microglia, Rats, Interleukin-1beta, Cold-Shock Response

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