The DOI matches its Crossref record; 149 of the 150 references it cites were found in a registry or an index.
Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
Open accessAbstract
Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.
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“Microglial cells express these receptors (TLR1-TLR9) and their co-receptors, which promote microglial activation (Gonzalez et al., 2014).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Gonzalez et al., 2014
In the citing paper
“M1 microglial cells present amoeboid morphology as well as high phagocytic capacity and motility (Varnum and Ikezu, 2012; Gonzalez et al., 2014; Jones and Bouvier, 2014).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Gonzalez et al., 2014
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Role of neuroinflammation in neurodegenerative diseases (Review)
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The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
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The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466
Balancing the immune response in the brain: IL-10 and its regulation
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Metadata
- Authors
- González, H., Elgueta, D., Montoya, A., & Pacheco, R.
- Affiliations
- Fundación Ciencia and Vida (CL)
- Universidad Andrés Bello (CL)
- Universidad San Sebastián (CL)
- Corresponding author
- Pacheco, Rodrigo
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 274
- Issue
- 1-2
- Pages
- 1-13
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2003129702
- Cited by
- 352
- References
- 150
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 24 · 2023: 24 · 2022: 19 · 2021: 45 · 2020: 34 · 2019: 38 · 2018: 46 · 2017: 30 · 2016: 28 · 2015: 33 · 2014: 6
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- FONDECYT (1130271)
- CONICYT (PFB-16)
- Universidad San Sebastián (2011-0001-R)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, neuroinflammation, neurodegenerative diseases, neuroimmune regulation, microglial activation, intercellular communication, microglia-neuron interaction, blood-brain barrier, T cell infiltration, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis
- MeSH terms
- Animals, Blood-Brain Barrier, Humans, Immune Tolerance, Neuritis, Neuroimmunomodulation, Microglia, Neurodegenerative Diseases
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