Cited by 256Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

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Appel, Stanley H., Beers, David R., Henkel, Jenny S.·2010·Trends in Immunology

Abstract

Neuroinflammation is a pathological hallmark in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and is characterized by activated microglia and infiltrating T cells at sites of neuronal injury. In PD and ALS, neurons do not die alone; neuronal injury is non-cell-autonomous and depends on a well-orchestrated dialogue in which neuronally secreted misfolded proteins activate microglia and initiate a self-propagating cycle of neurotoxicity. Diverse populations and phenotypes of CD4(+) T cells crosstalk with microglia, and depending on their activation status, influence this dialogue and promote neuroprotection or neurotoxicity. A greater understanding of the T cell population that mediates these effects, as well as the molecular signals involved should provide targets for neuroprotective immunomodulation to treat these devastating neurodegenerative diseases.

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Crossref · 10.1016/j.it.2009.09.003

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  1. [94]Benoit M 2008 Macrophage polarization in bacterial infections J Immunol 181 3733 3739 18768823
  2. [95]Dauer W Przedborski S 2003 Parkinson's disease: Mechanisms and Models Neuron 39 889 909 12971891

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Authors
Appel, S. H., Beers, D. R., & Henkel, J. S.
Affiliations
Houston Methodist (US)
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2010-01
Volume
31
Issue
1
Pages
7-17
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2034254855
Cited by
256
References
94
Citations by year
2026: 6 · 2025: 5 · 2024: 13 · 2023: 6 · 2022: 5 · 2021: 16 · 2020: 13 · 2019: 15 · 2018: 17 · 2017: 14 · 2016: 23 · 2015: 17 · 2014: 21 · 2013: 20 · 2012: 24
FWCI
1.66
Type
journal article
Language
en
Open access
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS048950, R01NS048950)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, amyotrophic lateral sclerosis, neuroinflammation, microglia, CD4+ T cells, neurotoxicity, neuroprotection, immunomodulation, neurodegenerative diseases
MeSH terms
Amyotrophic Lateral Sclerosis, Animals, Cell Communication, Parkinson Disease, T-Lymphocytes, Microglia, Mice

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