Effects of inflammatory cytokines IFN-γ, TNF-α and IL-6 on the viability and functionality of human pluripotent stem cell-derived neural cells
Abstract
Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease, where neural progenitor cell (NPC) transplantation has been suggested as a potential neuroprotective therapeutic strategy. Since the effect of inflammation on NPCs is poorly known, their effect on the survival and functionality of human NPCs were studied. Treatment with interleukin (IL)-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ did not induced cytotoxicity, but IFN-γ treatment showed decreased proliferation and neuronal migration. By contrast, increased proliferation and inhibition of electrical activity were detected after TNF-α treatment. Treatments induced secretion of inflammatory factors. Inflammatory cytokines appear to modulate proliferation as well as the cellular and functional properties of human NPCs.
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•NO inhibits the expression of the inflammatory cytokines IL-1β, TNF-α, IL-6, and IFN-γ in lymphocytes, eosinophils, and monocytes, in an effect mediated by nitrosylation of the transcription factors JAK/STAT and NF-κβ.
“Also, •NO inhibits the expression of the inflammatory cytokines IL-1β, TNF-α, IL-6, IFN-γ [116] in lymphocytes, eosinophils, and monocytes, in an effect mediated by nitrosylation of the transcription factors JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) and NF-κβ [117].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [116]
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- Authors
- Hagman, S., Mäkinen, A., Ylä-Outinen, L., Huhtala, H., Elovaara, I., & Narkilahti, S.
- Affiliations
- Tampere University (FI)
- University of Tampere (FI)
- Tampere University Hospital (FI)
- Corresponding author
- Narkilahti, Susanna
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 331
- Pages
- 36-45
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2889270618
- Cited by
- 31
- References
- 52
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 2
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Tampere University Institutional Repository (Tampere University) (submittedVersion)
- Funders
- Academy of Finland (122959)
- Tampere University Hospital (92109, 9M064)
- Finnish Cultural Foundation
- Karolinska Institute
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- inflammatory cytokines, interferon-gamma, TNF-α, interleukin-6, neural progenitor cells, multiple sclerosis, neuroprotection, cell proliferation, neuronal migration, electrical activity, neuroinflammation
- MeSH terms
- Astrocytes, Cell Division, Cells, Cultured, Gene Expression Regulation, Humans, Inflammation, Interferon-gamma, Nerve Net, Nerve Tissue Proteins, Neurons, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Receptors, Cytokine, Intercellular Signaling Peptides and Proteins, Pluripotent Stem Cells, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells, Time-Lapse Imaging, Single-Cell Analysis
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