An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients
Abstract
We have compared plasma redox status of coenzyme Q-10 in 20 sporadic amyotrophic lateral sclerosis (sALS) patients with those in 20 healthy age/sex-matched controls. A significant increase in the oxidized form of coenzyme Q-10 (sALS=109.3+/-95.2 nM; controls=23.3+/-7.5 nM, P=0.0002) and in the ratio of oxidized form of coenzyme Q-10 to total coenzyme Q-10 (%CoQ-10) (sALS=12.0+/-9.3%; controls=3.2+/-0.9%, P<0.0001) were observed. Moreover, %CoQ-10 correlated significantly with the duration of illness (rho=0.494, P=0.0315). Our finding suggests systemic oxidative stress in the pathogenesis of sALS.
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The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid of PD patients and in plasma of ALS patients.
“The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid (CSF) of PD patients156, 157 and in plasma of ALS patients158.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [158]
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- Authors
- Sohmiya, M., Tanaka, M., Suzuki, Y., Tanino, Y., Okamoto, K., & Yamamoto, Y.
- Affiliations
- Gunma University (JP)
- Tokyo University of Technology (JP)
- Corresponding author
- Sohmiya, Makoto
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 228
- Issue
- 1
- Pages
- 49-53
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2062885773
- Cited by
- 69
- References
- 24
- Citations by year
- 2024: 5 · 2023: 2 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- amyotrophic lateral sclerosis, coenzyme Q10, oxidative stress, disease duration, biomarkers
- MeSH terms
- Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Ascorbic Acid, Bilirubin, Chromatography, High Pressure Liquid, Coenzymes, Female, Follow-Up Studies, Humans, Male, Middle Aged, Oxidation-Reduction, Time Factors, Ubiquinone, Uric Acid, Case-Control Studies, Statistics, Nonparametric
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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