Cited by 143Coenzyme Q10 studies and effectsParkinson's Disease Mechanisms and TreatmentsAntioxidant Activity and Oxidative Stress

Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

Sohmiya, Makoto, Tanaka, Makoto, Wei Tak, Nyou, Yanagisawa, Makoto, Tanino, Yutaka, Suzuki, Yoko, Okamoto, Koichi, Yamamoto, Yorihiro·2004·Journal of the Neurological Sciences

Abstract

Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients.

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Crossref · 10.1016/j.jns.2004.05.007

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  • Significantly decreased levels of CoQ10 have been detected in cortex of post-mortem brain tissues of Parkinson's brains; level of oxidized form of ubiquinone increased compared to healthy subjects.

    “Significantly decreased levels of CoQ10 have been detected in the cortex of post-mortem brain tissues of Parkinson’s brains. In addition, the level of the oxidized form of ubiquinone has been found to be increased compared to healthy subjects (Sohmiya et al. 2004).”

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Authors
Sohmiya, M., Tanaka, M., Wei Tak, N., Yanagisawa, M., Tanino, Y., Suzuki, Y., Okamoto, K., & Yamamoto, Y.
Affiliations
  • Gunma University (JP)
  • The University of Tokyo (JP)
  • Tokyo University of Technology (JP)
Corresponding author
Sohmiya, Makoto
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2004-08
Volume
223
Issue
2
Pages
161-166
ISSN
0022-510X (ISSN-L)
OpenAlex
W2117733672
Cited by
143
References
52
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 6
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
Parkinson's disease, oxidative stress, coenzyme Q10, plasma biomarkers, redox state, neurodegeneration
MeSH terms
Adult, Aged, Aged, 80 and over, Alzheimer Disease, Chromatography, High Pressure Liquid, Coenzymes, Electrochemistry, Female, Humans, Male, Middle Aged, Oxidation-Reduction, Parkinson Disease, Plasma, Ubiquinone, Case-Control Studies, Oxidative Stress, Statistics, Nonparametric

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