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Cited by 86Coenzyme Q10 studies and effectsGenetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative Stress

Coenzyme Q and Its Role in the Dietary Therapy against Aging

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Varela-López, Alfonso, Giampieri, Francesca, Battino, Maurizio, Quiles, José·2016·Molecules
DOI 10.3390/molecules21030373PMC PMC6273282
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Abstract

Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally sufficient amounts of CoQ under normal physiological conditions. However, CoQ is a molecule found in different dietary sources, which can be taken up and incorporated into biological membranes. It is known that mitochondria have a close relationship with the aging process. Additionally, delaying the aging process through diet has aroused the interest of scientists for many years. These observations have stimulated investigation of the anti-aging potential of CoQ and its possible use in dietary therapies to alleviate the effects of aging. In this context, the present review focus on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases.

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Cited by

Sorted by citations

Authors
Varela-López, A., Giampieri, F., Battino, M., & Quiles, J.
Affiliations
  • Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center (CIBM), University of Granada, Avda. del Conocimiento s.n., Armilla, Granada 18100, Spain
  • Marche Polytechnic University (IT)
  • Universidad de Granada (ES)
Corresponding author
  • Battino, Maurizio
  • Quiles, José
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2016-03-18
Volume
21
Issue
3
Pages
373
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules21030373
PMC
PMC6273282
OpenAlex
W2298417771
Cited by
86
References
6
Citations by year
2026: 2 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 5
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by)
  • Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by-nc-nd)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fondazione Umberto Veronesi
  • Universidad de Granada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
coenzyme Q10, dietary therapy, aging, mitochondria, electron transport chain, antioxidant activity, signal transduction, age-related diseases, lifespan, membrane lipids
MeSH terms
Aging, Antioxidants, Diet Therapy, Humans, Mitochondria, Oxidation-Reduction, Ubiquinone, Oxidative Stress

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