Anhedonia and its correlation with clinical aspects in Parkinson’s disease
Abstract
Anhedonia is one of the non-motor symptoms observed in the Parkinson's disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with clinical aspects of PD in a relatively large cohort. We enrolled 318 patients with PD and 62 control subjects for this study. Patients and subjects were tested using the Snaith-Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition for the assessment of anhedonia and depression. We also investigated the correlation among clinical aspects of PD, anhedonia, and depression in patients with PD. The Snaith-Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition scores were significantly higher in patients with PD than in control subjects (p=0.03 and p=0.0006, respectively). All PD patients with anhedonia had a significantly higher score on the unified Parkinson's disease rating scale (UPDRS) parts I and II compared to PD patients without anhedonia. Additionally, all PD patients with depression scored significantly higher on UPDRS part I-IV than PD patients without depression. The patients with anhedonia and without depression had mild motor severity and their treatment was relatively low dosage. These results suggest that anhedonia and depression are slightly linked, but not the same. PD patients with only anhedonia may be closely linked apathy found in untreated early stages of PD.
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In Parkinson's disease, consummatory anhedonia is specifically blunted independently of depression.
“in Parkinson’s disease (characterized by the breakdown of dopamine-producing neurons), consummatory anhedonia is specifically blunted (160) independently of depression (161)”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [161]
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- Authors
- Nagayama, H., Maeda, T., Uchiyama, T., Hashimoto, M., Nomoto, N., Kano, O., Takahashi, T., Terashi, H., Hamada, S., Hasegawa, T., Hatano, T., Takahashi, T., Baba, Y., Sengoku, R., Watanabe, H., Inoue, M., Kadowaki, T., Kaneko, S., Shimura, H., & Kubo, S.-I.
- Affiliations
- Nippon Medical School (JP)
- Research Institute for Brain and Blood Vessels Akita (JP)
- Seirei Hamamatsu General Hospital (JP)
- Katsushika Medical Center (JP)
- Toho University Ohashi Medical Center (JP)
- Toho University Omori Medical Center (JP)
- Hiroshima University (JP)
- Tokyo Medical University (JP)
- Hokuyukai Neurology Hospital (JP)
- Tohoku University (JP)
- Juntendo University (JP)
- Jikei University School of Medicine (JP)
- Brain & Mind Research Center, Nagoya University (JP)
- SHOWA Medical University Fujigaoka Hospital (JP)
- Dokkyo Medical University (JP)
- Kansai Medical University (JP)
- Juntendo University Urayasu Hospital (JP)
- Corresponding author
- Nagayama, Hiroshi
- ORCID
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 372
- Pages
- 403-407
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2547354125
- Cited by
- 33
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 1
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16K09736)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- anhedonia, Parkinson's disease, depression, non-motor symptoms, apathy, Unified Parkinson's Disease Rating Scale, Snaith-Hamilton Pleasure Scale, motor impairment severity
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Depression, Female, Humans, Japan, Male, Middle Aged, Parkinson Disease, Psychiatric Status Rating Scales, Severity of Illness Index, Cohort Studies, Anhedonia
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