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Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity
Open accessAbstract
The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH). The results of the study did not show any differences in any of the outcome measures between CFS patients with and without psychiatric comorbidity, thus indicating that psychiatric status may not be an exacerbating factor in CFS. Importantly, significant differences were found between the pooled samples of CFS compared to controls. These included lower GSH and CBF and higher ventricular lactate and rates of spinal fluid abnormalities in CFS patients compared to healthy controls. Thirteen of 26 patients had abnormal values on two or more of these 4 brain-related variables. These findings, which replicate the results of several of our prior studies, support the presence of a number of neurobiological and spinal fluid abnormalities in CFS. These results will lead to further investigation into objective biomarkers of the disorder to advance the understanding of CFS.
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White-matter lesions have long been reported in connection with ME/CFS.
“white-matter lesions have long been reported in connection with ME/CFS62,63”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [62]
The Abstract (page unavailable) reports that earlier studies found more brain lesions on structural MRI in CFS patients without psychiatric comorbidity. It does not identify those lesions as white-matter lesions, so it supports the history of reported brain lesions but not the claim’s anatomical specificity. (LLM, conf=0.82)
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
SF-36 health survey: Manual and interpretation guide
Ware, J. (2003) · Medical Entomology and Zoology · Cited by 11,424
Krupp, L. B. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460115022 · Cited by 6,172
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969
McNair, D. M. (1992) · Medical Entomology and Zoology · Cited by 2,527
Wechsler Adult Intelligence Scale
(2007) · Sage eBooks · doi:10.4135/9781412952644.n478 · Cited by 2,017
L'examen psychologique ; Dans les cas d'ence-phalopathie traumatique (Les problemes)
Rey, A. (1941) · Medical Entomology and Zoology · Cited by 1,702
North American Adult Reading Test: Age Norms, Reliability, and Validity
Uttl, B. (2002) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.24.8.1123.8375 · Cited by 288
Shungu, D. C., Weiduschat, N., Murrough, J. W., Mao, X., Pillemer, S., Dyke, J. P., Medow, M. S., Natelson, B. H., Stewart, J. M., & Mathew, S. J. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2772 · Cited by 189
Self-citationL'examen psychologique dans les cas d'encéphalopathie traumatique. (Les problems.).
Rey, A. (1941) · Cited by 180
Brain MRI abnormalities exist in a subset of patients with chronic fatigue syndrome
Lange, G., DeLuca, J., Maldjian, J. A., Lee, H.-J., Tiersky, L. A., & Natelson, B. H. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00243-9 · Cited by 154
Self-citationDeLuca, J., Johnson, S. K., Ellis, S. P., & Natelson, B. H. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.2.151 · Cited by 138
Self-citationSpinal Fluid Abnormalities in Patients with Chronic Fatigue Syndrome
Natelson, B. H., Weaver, S., Tseng, C., & Ottenweller, J. E. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.1.52-55.2005 · Cited by 113
Self-citationCerebral blood flow is reduced in chronic fatigue syndrome as assessed by arterial spin labeling
Biswal, B. B., Kunwar, P. S., & Natelson, B. H. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.11.018 · Cited by 106
Self-citationPatients with chronic fatigue syndrome have reduced absolute cortical blood flow
Yoshiuchi, K., Farkas, J., & Natelson, B. H. (2006) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2006.00649.x · Cited by 106
Self-citationMathew, S. J., Mao, X., Keegan, K. A., Levine, S. M., Smith, E. L., Heier, L., Otcheretko, V., Coplan, J. D., & Shungu, D. C. (2008) · NMR in Biomedicine · doi:10.1002/nbm.1315 · Cited by 85
Self-citationMurrough, J. W., Mao, X., Collins, K. A., Kelly, C. A., Andrade, G., Nestadt, P. S., Levine, S. M., Mathew, S. J., & Shungu, D. C. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1512 · Cited by 83
Self-citationWhite, D. N., & Rb, B. (1954) · Neurology · doi:10.1212/wnl.4.7.506 · Cited by 66
Behavioral assessment of psychopathology in children: Infantile autism
Overall, J. E., & Campbell, M. (1988) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198809)44:5 · Cited by 50
Psychiatric morbidity in the chronic fatigue syndrome
Ciccone, D. S., Busichio, K., Vickroy, M., & Natelson, B. H. (2003) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00525-1 · Cited by 43
Self-citationElevations of ventricular lactate levels occur in both chronic fatigue syndrome and fibromyalgia
Natelson, B. H., Vu, D., Coplan, J. D., Mao, X., Blate, M., Kang, G., Soto, E., Kapusuz, T., & Shungu, D. C. (2017) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2017.1280114 · Cited by 38
Self-citationA twin study of cognitive function in chronic fatigue syndrome: The effects of sudden illness onset.
Claypoole, K. H., Noonan, C., Mahurin, R. K., Goldberg, J. H., Erickson, T., & Buchwald, D. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.4.507 · Cited by 37
A two‐year follow‐up study of chronic fatigue syndrome comorbid with psychiatric disorders
Matsuda, Y., Matsui, T., Kataoka, K., Fukada, R., Fukuda, S., Kuratsune, H., Tajima, S., Yamaguti, K., Kato, Y. H., & Kiriike, N. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.01954.x · Cited by 31
Natelson, B. H., Vu, D., Mao, X., Weiduschat, N., Togo, F., Lange, G., Blate, M., Kang, G., Coplan, J. D., & Shungu, D. C. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.08.004 · Cited by 21
Self-citationIllness Trajectories in the Chronic Fatigue Syndrome
Ciccone, D. S., Chandler, H. K., & Natelson, B. H. (2010) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3181e4ce0b · Cited by 20
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Komaroff, A. L., & Lipkin, W. I. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1187163 · Cited by 354
Komaroff, A. L., & Lipkin, W. I. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.06.002 · Cited by 276
Mueller, C., Lin, J. C., Sheriff, S., Maudsley, A. A., & Younger, J. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-018-0029-4 · Cited by 121
Shan, Z., Barnden, L. R., Kwiatek, R. A., Bhuta, S., Hermens, D. F., & Lagopoulos, J. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02506-6 · Cited by 86
Renz‐Polster, H., Tremblay, M., Bienzle, D., & Fischer, J. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.888232 · Cited by 56
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Self-citationMorris, M. C., Cooney, K. E., Sedghamiz, H., Abreu, M., Collado, F., Balbin, E. G., Craddock, T. J. A., Klimas, N. G., Broderick, G., & Fletcher, M. A. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.03.002 · Cited by 13
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Friedberg, F., & Choi, D. W. (2022) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2022.2038519 · Cited by 7
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Zhu, Y., Quan, P., Yamazaki, T., Norweg, A. M., Natelson, B. H., & Xu, X. (2025) · Immunometabolism · doi:10.1097/in9.0000000000000068 · Cited by 3
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Metadata
- Authors
- Natelson, B. H., Mao, X., Stegner, A. J., Lange, G., Vu, D., Blate, M., Kang, G., Soto, E., Kapusuz, T., & Shungu, D. C.
- Affiliations
- Mount Sinai Beth Israel (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Natelson, Benjamin H
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 375
- Pages
- 411-416
- ISSN
- 0022-510X (ISSN-L)
- PMC
- PMC5393352
- OpenAlex
- W2591142440
- Cited by
- 17
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 4
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1s10od021782-01, UL1TR002384)
- National Institute of Mental Health (R01MH100005)
- National Institute of Neurological Disorders and Stroke (R21NS075653)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- chronic fatigue syndrome, psychiatric comorbidity, cerebrospinal fluid abnormalities, cerebral blood flow, neuropsychological performance, biomarkers
- MeSH terms
- Adult, Analysis of Variance, Mental Disorders, Brain, Cerebrovascular Circulation, Female, Glutathione, Humans, Male, Middle Aged, Neuropsychological Tests, Magnetic Resonance Spectroscopy, Psychiatric Status Rating Scales, Cohort Studies, Fatigue Syndrome, Chronic, Lactic Acid
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