Cited by 726Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and SenescenceProteoglycans and glycosaminoglycans research

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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

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Loeser, R.F.·2009·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2009.03.002PMC PMC2713363

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Abstract

Objective Age-related changes in multiple components of the musculoskeletal system may contribute to the well established link between aging and osteoarthritis (OA). This review focused on potential mechanisms by which age-related changes in the articular cartilage could contribute to the development of OA.Methods The peer-reviewed literature published prior to February 2009 in the PubMed database was searched using pre-defined search criteria. Articles, selected for their relevance to aging and articular chondrocytes or cartilage, were summarized.Results Articular chondrocytes exhibit an age-related decline in proliferative and synthetic capacity while maintaining the ability to produce pro-inflammatory mediators and matrix degrading enzymes. These findings are characteristic of the senescent secretory phenotype and are most likely a consequence of extrinsic stress-induced senescence driven by oxidative stress rather than intrinsic replicative senescence. Extracellular matrix changes with aging also contribute to the propensity to develop OA and include the accumulation of proteins modified by non-enzymatic glycation.Conclusion The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of OA. A better understanding of the basic mechanisms underlying senescence and how the process may be modified could provide novel ways to slow the development of OA.

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Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724
"A Controlled Study"
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719
The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis
Sharma, L. (2001) · JAMA · doi:10.1001/jama.286.2.188 · Cited by 1,572
The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524
Oxidant signals and oxidative stress
Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393

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Rosen, 1997, Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation, Arthritis Rheum, 40, 1275
Pelletier, 2001, Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets, Arthritis Rheum, 44, 1237, 10.1002/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F · DOI

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Duan, Z., Li, Y.-S., Tu, C., Xie, P., Li, Y., Qi, L., & Li, Z. (2020) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-01756-w · Cited by 8
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RORβ modulates a gene program that is protective against articular cartilage damage
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Huang, C.-C., Lee, C., Wang, C., Wang, F., Huang, H., Ng, S., Tseng, C.-Y., & Ko, S. (2014) · BioMed Research International · doi:10.1155/2014/284784 · Cited by 8
Characterization of the Proliferating Layer Chondrocytes of Growth Plate for Cartilage Regeneration
Liu, Z., Shen, P., Lu, C., Chou, S., & Tien, Y.-C. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0110 · Cited by 8
Transcriptomic characterization elucidates a signaling network that controls antler growth
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FXR in bone metabolism: An emerging regulator
Rizvi, S. M. M. H., Aihemaiti, S., Kan, Y., Tao, S., & Liu, H. (2026) · iScience · doi:10.1016/j.isci.2026.114842 · Cited by 8
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Li, H., Wang, C., Liu, Q., Tong, Z., Song, B., Wei, W., & Teng, C. (2024) · ACS Omega · doi:10.1021/acsomega.3c10316 · Cited by 7
Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures
Dai, C., Jia, J., Kot, A., Liu, X., Liu, L., Jiang, M., Lane, N. E., Wise, B. L., & Yao, W. (2019) · Bone · doi:10.1016/j.bone.2019.115196 · Cited by 7
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Yan, J., Yao, L., Tan, Y. H. V., & Wang, Y. (2023) · Aging · doi:10.18632/aging.205024 · Cited by 7
Osteoarthritis and Chinese medicine: an overview of theories and evidence.
Hua, B., & O’Brien, K. (2010) · Victoria University Research Repository (Victoria University) · Cited by 7
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Lawrence, K. M., Jackson, T., Jamieson, D. G., Stevens, A., Owens, G. L., Sayan, B. S., Locke, I. C., & Townsend, P. A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.12.005 · Cited by 7
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Choi, J. Y., Babu, H., Joseph, F. N., Stephanie, S., & Suh, J. S. (2017) · Foot and Ankle Surgery · doi:10.1016/j.fas.2017.03.012 · Cited by 7
Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury
Bao, X., & Hu, X. (2018) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-018-2253-x · Cited by 8
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Smyth, T. T., Allen, A. L., & Carmalt, J. L. (2019) · American Journal of Veterinary Research · doi:10.2460/ajvr.80.12.1107 · Cited by 7
Effectiveness of Platelet-ich Plasma Based on Gene Expression in Knee Osteoarthritis.
Ghasroldasht, M. M., Moayednia, A., & Shahrezaee, M. (2019) · Europe PMC (PubMed Central) · Cited by 7
Recent Evidence for Orthobiologics Combined with Hydrogels for Joint Tissue Regeneration: Focus on Osteoarthritis
Cavallo, C., Desando, G., D’Alessandro, M., Grigolo, B., & Roseti, L. (2025) · Gels · doi:10.3390/gels11070551 · Cited by 8
Mitochondrial dysfunction exacerbates inflammatory responses via the JNK/p38-AP-1 pathway in primary cultured chondrocytes
Motonari, H., Hayashi, A., Tanaka, Y., Nakamura, Y., Hisaoka‐Nakashima, K., & Morioka, N. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115433 · Cited by 6
Benzophenone-3 drives osteoarthritis pathogenesis by regulating chondrocyte senescence
Zhu, Z., Wang, C., Wei, S., Wu, R., Zhao, W., Zhao, X., Li, Y.-J., & Ye-zhou, Y. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111757 · Cited by 6
Optimized Lipid Nanoparticle-Mediated mRNA Co-Delivery of SOX5/SOX9 Enables Synergistic Senescence Reversal for Osteoarthritis Therapy
Yu, Y., Ji, Z., Xu, H., Ma, M., Li, S., Yin, Z., Du, Y., Li, H., Liu, S., & Qian, W. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s544168 · Cited by 8
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Gong, Y., Wu, Y., Liu, Y., Chen, S., Zhang, F., Chen, F., Wang, C., Li, S., Hu, M., Huang, R., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1083904 · Cited by 6
Aging and osteoarthritis. Chronic nonspecific inflammation as a link between aging and osteoarthritis (a review)
Mendel, O. I., Luchikhina, L. V., & Mendel, W. (2015) · Advances in Gerontology · doi:10.1134/s2079057015040165 · Cited by 6

Authors: Loeser, R. F.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Loeser, R.F.
ORCID: Loeser, R.F.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2009-08
Volume: 17
Issue: 8
Pages: 971-979
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2009.03.002
PMC: PMC2713363
OpenAlex: W2025243746
Cited by: 726
References: 130
Citations by year: 2026: 39 · 2025: 55 · 2024: 48 · 2023: 51 · 2022: 39 · 2021: 75 · 2020: 57 · 2019: 48 · 2018: 35 · 2017: 46 · 2016: 43 · 2015: 49 · 2014: 36 · 2013: 29 · 2012: 27
FWCI: 3.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1661 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG016697, R01-AG-16697, P30AG021332)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR49003, R01AR049003)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: osteoarthritis, aging, chondrocyte senescence, articular cartilage, oxidative stress, replicative senescence, extracellular matrix, glycation, pro-inflammatory mediators, matrix-degrading enzymes, cartilage homeostasis
MeSH terms: Aging, Animals, Cartilage, Articular, Humans, Osteoarthritis, Oxidative Stress, Chondrocytes

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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

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