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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
Open accessAbstract
Objective Age-related changes in multiple components of the musculoskeletal system may contribute to the well established link between aging and osteoarthritis (OA). This review focused on potential mechanisms by which age-related changes in the articular cartilage could contribute to the development of OA.Methods The peer-reviewed literature published prior to February 2009 in the PubMed database was searched using pre-defined search criteria. Articles, selected for their relevance to aging and articular chondrocytes or cartilage, were summarized.Results Articular chondrocytes exhibit an age-related decline in proliferative and synthetic capacity while maintaining the ability to produce pro-inflammatory mediators and matrix degrading enzymes. These findings are characteristic of the senescent secretory phenotype and are most likely a consequence of extrinsic stress-induced senescence driven by oxidative stress rather than intrinsic replicative senescence. Extracellular matrix changes with aging also contribute to the propensity to develop OA and include the accumulation of proteins modified by non-enzymatic glycation.Conclusion The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of OA. A better understanding of the basic mechanisms underlying senescence and how the process may be modified could provide novel ways to slow the development of OA.
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“the age-related decline in the proliferative and synthetic capacities of articular chondrocytes may reduce subsequent tissue regeneration33.”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [33]
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“These findings suggest that UBX0101 can clear SnCs from aged articular cartilage, but the age-related decline in the proliferative and synthetic capacities of articular chondrocytes may reduce subsequent tissue regeneration33.”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [33]
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Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719
The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis
Sharma, L. (2001) · JAMA · doi:10.1001/jama.286.2.188 · Cited by 1,572
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524
Oxidant signals and oxidative stress
Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393
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Research works printed but not linked: 2
- Rosen, 1997, Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation, Arthritis Rheum, 40, 1275
- Pelletier, 2001, Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets, Arthritis Rheum, 44, 1237, 10.1002/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F · DOI
Cited by
Sorted by citations
Items 501–600 of 726
Immonen, J. A., & Siefring, C. (2018) · Cartilage · doi:10.1177/1947603517752432 · Cited by 6
Association between ACE polymorphisms and osteoarthritis susceptibility.
Qing, Z., & Ye, J. (2015) · Europe PMC (PubMed Central) · Cited by 6
Jenkins, N. D. M., Housh, T. J., Miramonti, A. A., McKay, B. D., Yeo, N. M., Smith, C. M., Hill, E. C., Cochrane, K. C., & Cramer, J. T. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.004 · Cited by 6
Elements of biomechanics correlated to the body mass index in knee osteoarthritis
Antonescu, E., Silişteanu, S. C., & Totan, M. (2020) · Balneo Research Journal · doi:10.12680/balneo.2020.366 · Cited by 6
PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS
Karateev, A. E., Karateev, D. E., & Давыдов, О. С. (2017) · Rheumatology Science and Practice · doi:10.14412/1995-4484-2016-693-704 · Cited by 7
Cell Count and Cell Density Decrease as Age Increases in Cadaveric Pediatric Medial Menisci
Albersheim, M. S., Fedje-Johnston, W., Carlson, C. S., ARNOCZKY, S. P., Tóth, F., Shea, K. G., Harper, L. R., Rendahl, A., & Tompkins, M. A. (2023) · Arthroscopy Sports Medicine and Rehabilitation · doi:10.1016/j.asmr.2023.100795 · Cited by 5
Karim, A., Khan, H. A., Ahmad, F., & Qaisar, R. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01967-9 · Cited by 5
Ha, J. S., Jo, A., Yeo, E. J., Kim, Y. W., Lim, J.-Y., Yun, S., Moon, S. W., & Choi, W.-S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103139 · Cited by 5
Liang, J., Hu, J., Hong, X., Zhou, M., Xia, G., Hu, L., Luo, S., Quan, K., Yan, J., Wang, S., et al. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05075-2 · Cited by 5
Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats
Patel, P. R., Tamas, I. P., Bas, M. V. D., Kegg, A., Hilliard, B. A., Lambi, A. G., Popoff, S. N., & Barbe, M. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413546 · Cited by 5
Iloh, G. U. P. (2013) · European Journal of Preventive Medicine · doi:10.11648/j.ejpm.20130102.11 · Cited by 5
Li, Y., Zhan, P., Wang, Q., Zhang, M., Huang, S., & Chen, D. (2022) · Bioengineered · doi:10.1080/21655979.2022.2031407 · Cited by 5
Inflammatory Process on Knee Osteoarthritis in Cyclists
Noriega, D. C., Caballero-García, A., Roche, E., Álvarez‐Mon, M., & Córdova, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113703 · Cited by 5
Huang, K., Fu, W., Wang, A., Du, G., Tang, H., Yin, L., Yin, Z., & Gao, W. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2343898 · Cited by 5
Cheng, Y., Liu, X., Qu, W., Wang, X., Su, H., Li, W., & Xu, W. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03222-4 · Cited by 5
Potential Mechanisms of PTA: Oxidative Stress
Coleman, M. C., Buckwalter, J. A., & Martin, J. A. (2015) · Springer eBooks · doi:10.1007/978-1-4899-7606-2_17 · Cited by 5
El-Aziz, G. S. A., Gomaa, W. M., Hegaze, A. H., Mustafa, H. N., & Al-Hibshi, A. M. (2019) · International Journal of Morphology · doi:10.4067/s0717-95022019000301089 · Cited by 5
Xu, Y., Dai, G.-J., Liu, Q., Ma, X., Li, L., Chen, W., & Lin, N. (2014) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-014-1761-2 · Cited by 5
Agten, H., Hoven, I. V., Hoorick, J. V., Vlierberghe, S. V., Luyten, F. P., & Bloemen, V. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1386692 · Cited by 5
Blockade of ZMIZ1‐GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage
Nam, J., Woo, H., Yang, J.-H., Kim, S. J., Lee, K. P., Yu, J. H., Park, T. J., Eyun, S., & Yang, S. (2025) · Advanced Science · doi:10.1002/advs.202404311 · Cited by 4
Maintaining high levels of HIF-1α protects osteoarthritis cartilage by activating autophagy
Chen, X., Feng, G., Shao, L., Lin, X., He, X., Yang, Y., Zhao, X. S., Yan, J., Ma, L., Zhou, Y., et al. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103027 · Cited by 5
Xu, F., Zhuang, C., Yao, L., Xu, Y., Cao, Q., Fu, Z., Wang, L., Zhu, Y., Xue, D., Zhang, N., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102138 · Cited by 6
Serum TSP-1 is a useful biomarker in severity assessment and the diagnosis of osteoarthritis
Che, X., Zhang, C., Zhuo, Y., Li, H., Ding, X., Wu, G., Cao, F., Zhang, G., Yin, Y., Guo, L., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07022-z · Cited by 4
Modeling treatment of osteoarthritis with standard therapy and senolytic drugs
Siewe, N., & Friedman, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0332763 · Cited by 4
Ding, X., Huang, J., Zhou, R., Che, X., Pang, Y., Liang, D., Lu, C., Zhuo, Y., Cao, F., Wu, G., et al. (2024) · Medicine · doi:10.1097/md.0000000000037611 · Cited by 4
Liu, Y., Jiang, W., Huang, J., & Zhong, L. (2024) · Medicine · doi:10.1097/md.0000000000038430 · Cited by 4
Temporomandibular joint disc responses to installation and removal of the experimental malocclusion
Zhang, Y., Xu, L., Xu, X., Xu, J., Liu, Q., Zhao, Y., & Wang, M. (2024) · Journal of Oral Rehabilitation · doi:10.1111/joor.13833 · Cited by 4
Li, K., Leng, Y., Lei, D., Zhang, H., Ding, M., & Lo, W. L. A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1424286 · Cited by 4
Degenerative joint changes of the thoracic spine with respect to sex and age
Bagwell, K. L., & Williams, F. (2022) · Revista Argentina de Antropología Biológica · doi:10.24215/18536387e054 · Cited by 4
Runx1 alleviates osteoarthritis progression in aging mice
Chen, H., Pi, C., Chen, M., Du, X., Cui, Y., Zhang, D., Guo, Q., Xie, J., & Zhou, X. (2023) · Journal of Histotechnology · doi:10.1080/01478885.2023.2281790 · Cited by 4
Loeser, R. F., & Lotz, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_11 · Cited by 5
Self-citationKim, K., Sohn, D. H., Kim, K., & Park, Y. M. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.4016 · Cited by 4
Oxidative Stress in Musculoskeletal Disorders – Bone Disease
Philippe, C., & Wittrant, Y. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_125 · Cited by 4
Blood tests and age-related changes in older people.
Blann, A. D. (2014) · PubMed · Cited by 4
Czech, A., Kiesz, M., Ognik, K., & Różański, P. (2016) · Medycyna Weterynaryjna · doi:10.21521/mw.5567 · Cited by 4
Prise en charge de l’arthrose du sujet très âgé
Cailleaux, P., Maheu, E., & Haguenauer, D. (2021) · Revue du Rhumatisme Monographies · doi:10.1016/j.monrhu.2021.01.004 · Cited by 4
Xu, Y., Dai, G.-J., Liu, Q., Zhu, H., Chen, W., Zhang, P., Zhao, T., & Lin, N. (2014) · 中医杂志：英文版 · doi:10.1016/s0254-6272(15)30050-9 · Cited by 4
Williams, A. (2014) · Nottingham ePrints (University of Nottingham) · Cited by 4
Farooqi, R., Maryam, H., Jaffar, H. M., & Malik, T. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2541850 · Cited by 3
Dinç, M., Soydemir, Ö. C., Karasu, R., Sarıçetin, A., & Bayrak, H. Ç. (2025) · Medicina · doi:10.3390/medicina61081461 · Cited by 3
Karim, A., Khan, H. A., Ahmad, F., & Qaisar, R. (2025) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2025.2563670 · Cited by 3
Chen, L., Li, J., Wang, S., Ren, R., Xiong, W., Gan, X., Kang, H., Wen, Y., Li, J., & He, L. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116450 · Cited by 4
Drug-Releasing Thermogel for Osteoarthritis Induction in an Animal Model
Piao, Z., Lee, H. J., & Jeong, B. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c01111 · Cited by 3
Li, J., Zhang, Y., Chen, Y., Li, Y., Dai, B., & Liu, P. (2024) · International Wound Journal · doi:10.1111/iwj.14773 · Cited by 3
RetractedKim, J. I., & Kang, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-75774-7 · Cited by 3
Biomarkers and Their Role in Understanding Osteoarthritis
Hlubek, R., Kušnierová, P., Walder, P., Bystronova, I., & Douša, P. (2025) · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · doi:10.55095/achot2024/051 · Cited by 3
Kelly, E., & Heron, N. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08666-0 · Cited by 3
Bian, G., Zhao, W., & Zhang, L. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2524091 · Cited by 3
Serum sodium/potassium ratio in patients with rheumatoid arthritis and osteoarthritis
Rozin, A. P., Pruzansky, J., Edoute, Y., & Balbir‐Gurman, A. (2010) · Rheumatology Reports · doi:10.4081/rr.2010.e5 · Cited by 3
Local and systemic risk factors for incidence and progression of osteoarthritis
Felson, D. T., & Zhang, Y. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-09138-1.00172-8 · Cited by 3
Postnatal morpho-functional development of a dog’s meniscus
Modina, S., Aidos, L., Millar, V. R. H., Pallaoro, M., Polito, U., Veronesi, M. C., Peretti, G. M., Mangiavini, L., Carnevale, L., Boschetti, F., et al. (2023) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2023.152141 · Cited by 3
Xie, T., Ren, X., Zhuang, H., Jiang, F., Zhang, Y., & Zhou, P. (2023) · PubMed Central · Cited by 3
Wahba, A. S., Mohamed, D. A., Mehanna, M., Mesbah, N. M., Abo–Elmatty, D. M., & Mehanna, E. T. (2023) · Diagnostics · doi:10.3390/diagnostics13233544 · Cited by 3
Cervical arthritis, C3-C7, from an identified osteological collection
Williams, F., & Quispe, B. I. (2018) · Revista Argentina de Antropología Biológica · doi:10.17139/raab.2019.0021.01.04 · Cited by 3
Narrative Review of Subchondral Bone Morphology on Cartilage Damage (Osteoarthritis)
Mahendra, N. Y., Putra, D. P., Akbar, I., Putra, R. U., Prakoso, A. T., Yanis, M. N., Chandra, H., Syahrom, A., Amrullah, M. I., Jamari, J., et al. (2022) · Atlantis highlights in engineering/Atlantis Highlights in Engineering · doi:10.2991/ahe.k.220205.014 · Cited by 3
Mancini, A., Raimondo, S., Segni, C. D., Persano, M., Geronimo, E. D., Silvestrini, A., Pontecorvi, A., Meucci, E., & Tamburrelli, F. C. (2014) · PubMed · Cited by 3
OXIDATIVE STRESS INCIDENCE ON THE SEVERITY OF KNEE OSTEOARTHRITIS
Oikonomidis, S. A., Simos, Y. V., Toliopoulos, I. K., Verginadis, I. I., Oikonomidis, A. S., Ragos, V., Karkabounas, S. C., Evangelou, A. M., & Peschos, D. (2017) · Journal of Musculoskeletal Research · doi:10.1142/s0218957717500087 · Cited by 3
Bolton, S. N. (2015) · Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton) · Cited by 3
Surulescu, C., Grosjean, E., Dauner, M., Doser, M., Jäger, H., Keilmann, A., Linti, C., Mohanan, S. C., Teixeira, G. Q., Redenbach, C., et al. (2025) · Applied Mathematical Modelling · doi:10.1016/j.apm.2025.116535 · Cited by 2
Theodorou, S. J., Theodorou, D. J., Kigka, V. I., Gkiatas, I. S., & FOTOPOULOS, A. D. (2024) · Rheumatology International · doi:10.1007/s00296-024-05622-4 · Cited by 2
Molecular basis of senescence in osteoarthritis
Lawson, M. G., & Ritchison, H. M. (2024) · doi:10.32948/ajsep.2024.11.22 · Cited by 2
Chang, Y.-C., Cheng, Y., Liu, W.-C., Zhong, W., & Tsao, C. (2025) · Biomedical Materials · doi:10.1088/1748-605x/add6f8 · Cited by 2
Doucet, R., El-Seoudi, A., Rostami-Afshari, B., Elbakry, M., Taheri, M., Pellicelli, M., Picard, C., Lavoie, J.-F., Wang, D. S., Lavigne, P., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136281 · Cited by 2
Chondrocyte Senescence in Osteoarthritis: Potential Targets and Pharmacological Interventions
Tan, D. Y., Guo, J., Wang, T., Yang, S., Liu, J., Wang, D., & Li, W. (2026) · Cartilage · doi:10.1177/19476035251414314 · Cited by 2
Medoro, A., Tardugno, R., Davinelli, S., Clodoveo, M. L., Iorio, E. L., Tsolaki, M., Corbo, F., & Scapagnini, G. (2026) · Mediators of Inflammation · doi:10.1155/mi/5347893 · Cited by 2
Roux, C. H. (2020) · EMC - Podología · doi:10.1016/s1762-827x(20)44250-6 · Cited by 2
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Мякишева, С. Н., Linkova, N. S., Kozhevnikova, E. O., Полякова, В. О., & Ryzhak, G. A. (2023) · Успехи геронтологии · doi:10.34922/ae.2023.36.2.011 · Cited by 2
The efficacy and safety of Nigella sativa in the management of osteoarthritis: A systematic review
Mousavi, S. E., Noori, M., Marandi, H., Fazlollahi, A., Nejadghaderi, S. A., Rahmani, S., Noordoost, M., Karamzad, N., Sullman, M. J. M., Kolahi, A., et al. (2024) · Health Science Reports · doi:10.1002/hsr2.1989 · Cited by 2
IL-1 receptor antagonist: etiological and drug delivery systems overview
Ubhe, A. (2024) · Inflammation Research · doi:10.1007/s00011-024-01960-y · Cited by 2
Lynskey, S. J., Ling, Z., Ziemann, M., Gill, S. D., McGee, S. L., & Page, R. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073145 · Cited by 2
Lin, Y., Chen, Q., Liu, S., & Liu, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-98283-7 · Cited by 2
Huang, L., Deng, X., Jin, Y., Li, J., Wu, X., Xiong, Y., Guo, S., Yan, S., Lu, S., & Chen, D. (2025) · Journal of Pain Research · doi:10.2147/jpr.s547968 · Cited by 2
Intra-articular platelet rich plasma in osteoarthritis knee
Rawat, P. K., Agarwal, R., Ahuja, Y., Nagar, M. M., Kothiyal, P., Vij, K., & Gupta, P. (2021) · International Journal of Orthopaedics Sciences · doi:10.22271/ortho.2021.v7.i4i.2940 · Cited by 2
TMJ Degenerative Changes in SAMP3 Mice by Occlusal Disharmony and Aging
Abir, E., Wakamatsu, N., Iinuma, M., Nagayama, M., & Tamura, Y. (2012) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.21.399 · Cited by 2
Cardiovascular and Functional Capacity of Patients with Knee Osteoarthritis
Kunduracılar, Z., & Selici, K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81680 · Cited by 3
Basic Science Concepts in Musculoskeletal Regenerative Medicine
Bean, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-42771-9_2 · Cited by 2
Cheng, C., Tian, J., Gao, S., Zhou, Z., Yang, R., Xiao, K., Guo, W., Liu, L., Yang, H., & Zhang, F. (2022) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000001063 · Cited by 2
Macrophage migration inhibitory factor reversed senescent phenotype in human chondrocytes in vitro
Fu, Z., Li, Q., Jiang, P., Song, X., Yang, J., Chen, G., Gong, X., & Yang, L. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09101-0 · Cited by 2
Rovensky, Y. A. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-304-2_2 · Cited by 2
Spinelli, L. D. F., Pagnussato, F., Ribeiro, T. A., Guareze, F. S., Feder, M. G., Macedo, C. A. D. S., Moreira, L. F., & Gália, C. R. (2018) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/0100-6991e-20181985 · Cited by 2
Schrobback, K. (2010) · Cited by 2
Extending the Paradigm of Osteoarthritis: Comment on the Editorial by McAlindon
Hardingham, T. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39500 · Cited by 2
A network medicine approach to elucidate mechanisms underlying menopause-induced knee osteoarthritisPreprint
Gilmer, G. G., Iijima, H., Jackson, N., Hettinger, Z. R., Bean, A., Bergmann, J., Evans, C., Thurston, R. C., & Ambrosio, F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.02.530756 · Cited by 2
Specificities of oxidative stress in the blood and synovial fluid in knee osteoarthritis
Внуков, В. В., Panina, S., Krolevets, I. V., Milutina, N. P., Ananyan, A. A., Zabrodin, M. A., & Plotnikov, A. A. (2015) · Advances in Gerontology · doi:10.1134/s2079057015040220 · Cited by 1
Xu, W., Xue, Z., Xie, G., Xi, H., Yang, H., Lou, Y., Zhao, M., & Wang, Q. (2025) · ACS Omega · doi:10.1021/acsomega.5c02130 · Cited by 1
Amorim, P. A., Agten, H., Vermeulen, M., Vlierberghe, S. V., Geris, L., & Bloemen, V. (2025) · Gels · doi:10.3390/gels11090698 · Cited by 2
Maniglio, M., Saggaf, M. M., Purohit, N., Antflek, D., Rockel, J. S., Kapoor, M., & Baltzer, H. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209856 · Cited by 1
Water-Based Wellness: Unlocking Physical Resilience and Functional Longevity in Ageing Population
Shukla, A. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1011381 · Cited by 1
Wen, X., An, S., Zhou, X., Bi, X., & Sun, S. (2026) · Journal of Orthopaedics · doi:10.1016/j.jor.2026.02.050 · Cited by 1
Lubricin in osteoarthritis: functions and therapeutic prospects
Li, H., Yi, G., Zhou, D., Zhou, J., Cui, Z., Zhang, H., & Chen, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1790804 · Cited by 1
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Love, R. J., Sheridan, J., Funk, C., & Young, J.-L. (2026) · Pain and Therapy · doi:10.1007/s40122-026-00880-5 · Cited by 1
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Metadata
- Authors
- Loeser, R. F.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Loeser, R.F.
- ORCID
- Loeser, R.F.
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 17
- Issue
- 8
- Pages
- 971-979
- ISSN
- 1063-4584 (ISSN-L)
- PMC
- PMC2713363
- OpenAlex
- W2025243746
- Cited by
- 726
- References
- 130
- Citations by year
- 2026: 39 · 2025: 55 · 2024: 48 · 2023: 51 · 2022: 39 · 2021: 75 · 2020: 57 · 2019: 48 · 2018: 35 · 2017: 46 · 2016: 43 · 2015: 49 · 2014: 36 · 2013: 29 · 2012: 27
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Osteoarthritis and Cartilage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG016697, R01-AG-16697, P30AG021332)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR49003, R01AR049003)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- osteoarthritis, aging, chondrocyte senescence, articular cartilage, oxidative stress, replicative senescence, extracellular matrix, glycation, pro-inflammatory mediators, matrix-degrading enzymes, cartilage homeostasis
- MeSH terms
- Aging, Animals, Cartilage, Articular, Humans, Osteoarthritis, Oxidative Stress, Chondrocytes
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