Cited by 726Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and SenescenceProteoglycans and glycosaminoglycans research

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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

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Loeser, R.F.·2009·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2009.03.002PMC PMC2713363

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Abstract

Objective Age-related changes in multiple components of the musculoskeletal system may contribute to the well established link between aging and osteoarthritis (OA). This review focused on potential mechanisms by which age-related changes in the articular cartilage could contribute to the development of OA.Methods The peer-reviewed literature published prior to February 2009 in the PubMed database was searched using pre-defined search criteria. Articles, selected for their relevance to aging and articular chondrocytes or cartilage, were summarized.Results Articular chondrocytes exhibit an age-related decline in proliferative and synthetic capacity while maintaining the ability to produce pro-inflammatory mediators and matrix degrading enzymes. These findings are characteristic of the senescent secretory phenotype and are most likely a consequence of extrinsic stress-induced senescence driven by oxidative stress rather than intrinsic replicative senescence. Extracellular matrix changes with aging also contribute to the propensity to develop OA and include the accumulation of proteins modified by non-enzymatic glycation.Conclusion The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of OA. A better understanding of the basic mechanisms underlying senescence and how the process may be modified could provide novel ways to slow the development of OA.

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Authors: Loeser, R. F.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Loeser, R.F.
ORCID: Loeser, R.F.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2009-08
Volume: 17
Issue: 8
Pages: 971-979
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2009.03.002
PMC: PMC2713363
OpenAlex: W2025243746
Cited by: 726
References: 130
Citations by year: 2026: 39 · 2025: 55 · 2024: 48 · 2023: 51 · 2022: 39 · 2021: 75 · 2020: 57 · 2019: 48 · 2018: 35 · 2017: 46 · 2016: 43 · 2015: 49 · 2014: 36 · 2013: 29 · 2012: 27
FWCI: 3.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1661 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG016697, R01-AG-16697, P30AG021332)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR49003, R01AR049003)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: osteoarthritis, aging, chondrocyte senescence, articular cartilage, oxidative stress, replicative senescence, extracellular matrix, glycation, pro-inflammatory mediators, matrix-degrading enzymes, cartilage homeostasis
MeSH terms: Aging, Animals, Cartilage, Articular, Humans, Osteoarthritis, Oxidative Stress, Chondrocytes

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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

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