Meta-analysis of the relationship between homocysteine, vitamin B12, folate, and multiple sclerosis
Abstract
A meta-analysis was conducted to assess the relationship between serum homocysteine, vitamin B(12), and folate levels in patients with multiple sclerosis (MS). The DerSimonian and Laird Q test was used to evaluate the degree of heterogeneity between studies and a funnel plot was used to assess publication bias. The pooled effect size (standardized mean difference [SMD]) between patients with MS and control patients) from a random effects model was 0.84 (95% confidence interval: 0.18, 1.49) for homocysteine and -0.25 (-0.45, -0.04) for vitamin B(12), and from a fixed effects model was 0.98 (0.80, 1.16) for homocysteine and -0.25 (-0.41, -0.09) for vitamin B(12). Both nutrients were statistically significant, but the SMD for folate was not. Patients with MS were found to have raised homocysteine levels but low B(12) levels, which might contribute to the pathogenesis of MS.
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Seven meta-analyses comprised studies with high (>90%) average power.
“However, seven meta-analyses comprised studies with high (>90%) average power 24,26,31,57,63,68,71 .”
From Power failure: why small sample size undermines the reliability of neuroscience (2013) · cites this paper as [71]
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- Authors
- Zhu, Y., He, Z.-Y., & Liu, H.-N.
- Affiliations
- First Hospital of China Medical University (CN)
- Corresponding author
- Zhu, Ying
- ORCID
- Zhu, Ying
- Venue
- Journal of Clinical Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 18
- Issue
- 7
- Pages
- 933-938
- ISSN
- 0967-5868 (ISSN-L)
- OpenAlex
- W1969078199
- Cited by
- 75
- References
- 51
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 2
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Keywords
- multiple sclerosis, homocysteine, vitamin B12, folic acid, serum biomarkers, pathogenesis, hyperhomocysteinemia, vitamin deficiency
- MeSH terms
- Folic Acid, Homocysteine, Humans, Multiple Sclerosis, Vitamin B 12
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