Clinical, MRI and 18F-FDG-PET/CT analysis of progressive supranuclear palsy
Abstract
Background Progressive supranuclear palsy (PSP) is a kind of neurodegenerative disease. In the present study, the clinical and magnetic resonance imaging (MRI) features of PSP were analyzed, and fluorodeoxyglucose positron emission tomography (FDG PET) brain imaging was performed to preliminarily explore the characteristics of cerebral glucose metabolism, so as to make a more accurate and differential diagnosis.Methods In accordance with the diagnostic criteria, the clinical symptoms, the unified Parkinson's disease rating scale (UPDRS), the mini-mental state examination (MMSE), the activities of daily living (ADL), and the magnetic resonance image (MRI) of 19 patients with PSP were examined and FDG-PET brain imaging was performed. Visual analysis and statistical parameter diagram were used to analyze the characteristics.Results Concerning the clinical characteristics, 84.21% of the patients with PSP had early recurrent falls, 63.15% had vertical supranuclear ophthalmoplegia, and 47.37% had symptoms of dementia. The MRI scans showed that 57.89% of the patients had a "hummingbird" sign in the middle sagittal position. The FDG-PET imaging indicated that glucose metabolism in the midbrain and frontal lobe was decreased in patients with PSP.Conclusions Studying the clinical and MRI features of patients with PSP can be helpful in the diagnosis, especially as some signs could be found in the early stage by FDG PET, enhancing early diagnosis and differentiation.
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PET-CT imaging showed lower glucose metabolism in the frontal lobe of patients with PSP than those with PD at the early stage.
“Meanwhile, PET-CT imaging also showed lower glucose metabolism in the frontal lobe of patients with PSP than those with PD at the early stage [64, 65], which indirectly further verifies our findings.”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [65]
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- Authors
- Zhao, P., Zhang, B., Gao, S., & Li, X.
- Affiliations
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Corresponding author
- Zhao, Ping
- Venue
- Journal of Clinical Neuroscience
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 80
- Pages
- 318-323
- ISSN
- 0967-5868 (ISSN-L)
- OpenAlex
- W3042153146
- Cited by
- 20
- References
- 23
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- progressive supranuclear palsy, neurodegenerative diseases, FDG-PET, brain glucose metabolism, MRI findings, hummingbird sign, supranuclear ophthalmoplegia, falls, dementia, differential diagnosis, frontal lobe hypometabolism
- MeSH terms
- Positron Emission Tomography Computed Tomography, Activities of Daily Living, Aged, Aged, 80 and over, Brain, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Supranuclear Palsy, Progressive, Fluorodeoxyglucose F18, Early Diagnosis
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