Frontal deficits differentiate progressive supranuclear palsy from P arkinson's disease
Abstract
The clinical differentiation of progressive supranuclear palsy from P arkinson's disease can be challenging, due to overlapping clinical features and a lack of diagnostic markers. Abnormalities in cognitive function form part of the clinical spectrums of these diseases and distinctive cognitive profiles may be helpful in differentiating these diseases in the diagnostic period. A comprehensive neuropsychological test battery was administered to 12 patients with clinically diagnosed progressive supranuclear palsy and 12 patients with P arkinson's disease matched for age and disease duration. Effect size ( C ohen's d ) was calculated for cognitive tests that were significantly different between groups. Patients with progressive supranuclear palsy performed significantly worse than those with P arkinson's disease on measures of processing speed, verbal fluency, planning, verbal abstract reasoning, verbal memory, and made more perseverative responses on a set shifting task. Measures of executive function, manual dexterity and processing speed were most diagnostically useful ( C ohen's d > 2.0) in differentiating between progressive supranuclear palsy and P arkinson's disease. These findings suggest that more severe and prominent ‘frontal’ cognitive deficits in patients with progressive parkinsonism would be helpful in predicting progressive supranuclear palsy rather than P arkinson's disease and these findings may contribute to the development of diagnostic criteria.
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PET-CT imaging showed lower glucose metabolism in the frontal lobe of patients with PSP than those with PD at the early stage.
“Meanwhile, PET-CT imaging also showed lower glucose metabolism in the frontal lobe of patients with PSP than those with PD at the early stage [64, 65], which indirectly further verifies our findings.”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [64]
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The discriminative linguistic profiles of progressive supranuclear palsy and Parkinson's disease
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- Authors
- Lee, Y. C., Williams, D. R., & Anderson, J. F. I.
- Affiliations
- Melbourne School of Psychological Sciences University of Melbourne Victoria Australia
- The Alfred Hospital (AU)
- The University of Melbourne (AU)
- Corresponding author
- Anderson, Jacqueline F. I.
- Venue
- Journal of Neuropsychology
- Publisher
- Wiley
- Published
- 2014-09-16
- Volume
- 10
- Issue
- 1
- Pages
- 1-14
- ISSN
- 1748-6645 (ISSN-L)
- 1748-6653
- OpenAlex
- W2104052604
- Cited by
- 26
- References
- 45
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Victorian Brain Bank
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- progressive supranuclear palsy, Parkinson's disease, differential diagnosis, frontal lobe dysfunction, executive function, processing speed, perseveration, set-shifting, verbal fluency, planning, verbal memory, cognitive profile
- MeSH terms
- Aged, Cognition, Diagnosis, Differential, Female, Humans, Male, Neuropsychological Tests, Parkinson Disease, Supranuclear Palsy, Progressive, Case-Control Studies
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