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Cited by 234Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchNeurological diseases and metabolism

Voxel-based morphometry in autopsy proven PSP and CBD

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Josephs, Keith A., Whitwell, Jennifer L., Dickson, Dennis W., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Parisi, Joseph E., Jack, Clifford R.·2008·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2006.09.019PMC PMC2702857
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Abstract

The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.

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  • CXCR4 and EGFR demonstrated elevated transcripts within the cerebellum and deep gray nuclei, regions more affected in CBD and PSP than FTD.

    “Interestingly, CXCR4 and EGFR demonstrated elevated transcripts within the cerebellum and deep gray nuclei (thalamus and globus pallidus), regions more affected in CBD and PSP than FTD [6, 22, 34].”

    From Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia (2017) · cites this paper as [22]

    The Discussion (page unavailable) reports pallidal atrophy in CBD and apparent cerebellar-region atrophy in PSP, supporting involvement of some named regions. It does not establish that these regions are more affected in CBD and PSP than in FTD. This MRI study also does not report CXCR4 or EGFR transcript levels, although the multiple citations do not identify this paper as the source of that finding. (LLM, conf=0.83)

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Authors
Josephs, K. A., Whitwell, J. L., Dickson, D. W., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., & Jack, C. R.
Affiliations
  • Mayo Clinic (US)
  • Mayo Clinic in Florida (US)
Corresponding author
Josephs, Keith A.
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2008-02
Volume
29
Issue
2
Pages
280-289
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2006.09.019
PMC
PMC2702857
OpenAlex
W2076342549
Cited by
234
References
1
Citations by year
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FWCI
6.73
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Mayo Foundation for Medical Education and Research
  • National Institutes of Health
  • National Institute on Aging (R01AG11378, P50‐AG16574, U01AG06786, U01AG006786, R01AG011378, P50AG016574)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD049078, K12 HD 49078)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
progressive supranuclear palsy, corticobasal degeneration, brain atrophy patterns, gray matter atrophy, white matter atrophy, brainstem atrophy, extrapyramidal symptoms, dementia syndromes, regional brain atrophy
MeSH terms
Aged, Aged, 80 and over, Autopsy, Basal Ganglia, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Supranuclear Palsy, Progressive, Statistics, Nonparametric, Neurodegenerative Diseases, Imaging, Three-Dimensional

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