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Cited by 26Pain Mechanisms and TreatmentsOsteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitation

Neural and immune roles in osteoarthritis pain: Mechanisms and intervention strategies

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Zou, Yi, Liu, Changyu, Wang, Zhenggang, Li, Guanghui, Xiao, Jun·2024·Journal of Orthopaedic Translation
DOI 10.1016/j.jot.2024.07.010PMC PMC11363721
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Abstract

Pain is the leading symptom for most individuals with osteoarthritis (OA), a complex condition marked by joint discomfort. Recently, the dynamic interplay between the nervous and immune systems has become a focal point for understanding pain regulation. Despite this, there is still a substantial gap in our comprehensive understanding of the neuroimmune interactions and their effects on pain in OA. This review examines the bidirectional influences between immune cells and nerves in OA progression. It explores current approaches that target neuroimmune pathways, including promoting M2 macrophage polarization and specific neuronal receptor targeting, for effective pain reduction. Translational potential statement: This review provides a comprehensive overview of the mechanisms underlying the interplay between the immune system and nervous system during the progression of OA, as well as their contributions to pain. Additionally, it compiles existing intervention strategies targeting neuroimmunity for the treatment of OA pain. This information offers valuable insights for researchers seeking to address the challenge of OA pain.

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Cited by

Sorted by citations

Authors
Zou, Y., Liu, C., Wang, Z., Li, G., & Xiao, J.
Affiliations
Tongji Hospital (CN)
Corresponding author
  • Li, Guanghui
  • Xiao, Jun
ORCID
Venue
Journal of Orthopaedic Translation
Publisher
Elsevier BV
Published
2024-09
Volume
48
Pages
123-132
ISSN
2214-031X (ISSN-L)
DOI
10.1016/j.jot.2024.07.010
PMC
PMC11363721
OpenAlex
W4401386012
Cited by
26
References
4
Citations by year
2026: 11 · 2025: 13 · 2024: 2
FWCI
1.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Orthopaedic Translation (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords
osteoarthritis pain, neuroimmunity, neuroimmune interactions, M2 macrophage polarization, neuronal receptors, pain modulation

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