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The effect of Substance P/Heparin conjugated PLCL polymer coating of bioinert ePTFE vascular grafts on the recruitment of both ECs and SMCs for accelerated regeneration

Kim, D., Chung, J. J., Jung, Y., & Kim, S. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-53514-6 · Cited by 35 · see citing works

Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective

Lan, H., We, Z., Jin, K., Liu, Y., & Wang, Z. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1809559 · Cited by 34 · see citing works

Angiotensin-converting enzyme (ACE) inhibitor prescription affects non-small-cell lung cancer (NSCLC) patients response to PD-1/PD-L1 immune checkpoint blockers

Medjebar, S., Truntzer, C., Perrichet, A., Limagne, E., Fumet, J.-D., Richard, C., Elkrief, A., Routy, B., Rébé, C., & Ghiringhelli, F. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1836766 · Cited by 34 · see citing works

Aedes aegypti sialokinin facilitates mosquito blood feeding and modulates host immunity and vascular biology

Martín-Martín, I., Leon, P. C. V., Amo, L., Shrivastava, G., Iniguez, E., Aryan, A., Brooks, S., Kojin, B. B., Williams, A. E., Bolland, S. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110648 · Cited by 34 · see citing works

Substance P accelerates wound repair by promoting neovascularization and preventing inflammation in an ischemia mouse model

Kim, S., Piao, J., Hwang, D. Y., Park, J. S., Son, Y., & Hong, H. S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.015 · Cited by 32 · see citing works

Neurokinin-1 Receptor Antagonists against Hepatoblastoma

Muñoz, M., Rosso, M., & Coveñas, R. (2019) · Cancers · doi:10.3390/cancers11091258 · Cited by 31 · see citing works

COVID-19 Usurps Host Regulatory Networks

Curran, C. S., Rivera, D. R. R., & Kopp, J. B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01278 · Cited by 30 · see citing works

Neuropeptides in Cancer: Friend and Foe?

Wu, Y., Berisha, A., & Borniger, J. C. (2022) · Advanced Biology · doi:10.1002/adbi.202200111 · Cited by 30 · see citing works

A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization, extracellular matrix deposition, and nerve regeneration

Li, H., Li, M., Liu, P., Wang, K., Fang, H., Yin, J., Zhu, D., Yang, Q., Gao, J., Ke, Q., et al. (2021) · Biomaterials Science · doi:10.1039/d1bm00357g · Cited by 29 · see citing works

Substance P enhances BMSC osteogenic differentiation via autophagic activation

Geng, W., Shi, H., Zhang, X., Tan, W., Cao, Y., & Mei, R. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10257 · Cited by 29 · see citing works

The role of peptidase neurolysin in neuroprotection and neural repair after stroke

Karamyan, V. T. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.284904 · Cited by 28 · see citing works

The role of neuropeptides in cutaneous wound healing: a focus on mechanisms and neuropeptide-derived treatments

Xing, L., Chen, B., Qin, Y., Li, X., Zhou, S., Yuan, K., Zhao, R., & Qin, D. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1494865 · Cited by 27 · see citing works

Impaired functional capacity of polarised neonatal macrophages

Dreschers, S., Ohl, K., Schulte, N., Tenbrock, K., & Orlikowsky, T. W. (2020) · Scientific Reports · doi:10.1038/s41598-019-56928-4 · Cited by 27 · see citing works

The Role of Neuropeptides in Pathogenesis of Dry Eye

Hwang, D. D.-J., Lee, S. J., Kim, J., & Lee, S. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184248 · Cited by 27 · see citing works

Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes

Widiapradja, A., Kasparian, A. O., McCaffrey, S. L., Kolb, L. L., Imig, J. D., Lacey, J. L., Meléndez, G. C., & Levick, S. P. (2021) · Cells · doi:10.3390/cells10102659 · Cited by 27 · see citing works

LBO-EMSC Hydrogel Serves a Dual Function in Spinal Cord Injury Restoration via the PI3K-Akt-mTOR Pathway

Yu, Q., Liao, M., Sun, C., Zhang, Q., Deng, W., Cao, X., Wang, Q., Omari‐Siaw, E., Bi, S., Zhang, Z., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c12013 · Cited by 27 · see citing works

Substance P promotes epidural fibrosis via induction of type 2 macrophages

Feng, H., Wang, H., Bai, Y.-F., Sun, J.-P., Wang, W.-S., Xu, Y., Wang, W.-S., & Liu, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.369120 · Cited by 27 · see citing works

Neural and immune roles in osteoarthritis pain: Mechanisms and intervention strategies

Zou, Y., Liu, C., Wang, Z., Li, G., & Xiao, J. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.07.010 · Cited by 26 · see citing works

mTOR Signaling in Macrophages: All Depends on the Context

Fedor, A., Bryniarski, K., & Nazimek, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157598 · Cited by 26 · see citing works

Modification of Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles by Calcitonin Gene Related Peptide (CGRP) Antagonist: Potential Implications for Inflammation and Pain Reversal

Liebmann, K., Castillo, M. A., Jergová, S., Best, T. M., Sagen, J., & Kouroupis, D. (2024) · Cells · doi:10.3390/cells13060484 · Cited by 26 · see citing works

Neuroimmune Interaction: A Widespread Mutual Regulation and the Weapons for Barrier Organs

Zhu, Y., Duan, S., Wang, M., Deng, Z., & Li, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.906755 · Cited by 25 · see citing works

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Zhan, C., Dai, Q., Ren, J., Jin, L., Wang, W., Ye, Z., Tsoi, J. K. H., & Lin, Y. (2025) · Advanced Science · doi:10.1002/advs.202506438 · Cited by 24 · see citing works

Anti-Aging Potential of Substance P-Based Hydrogel for Human Skin Longevity

Kim, D. J., Chang, S. S., & Lee, J. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184453 · Cited by 24 · see citing works

Substance-P Inhibits Cardiac Microvascular Endothelial Dysfunction Caused by High Glucose-Induced Oxidative Stress

‍Kim, D. Y., Piao, J., & Hong, H. S. (2021) · Antioxidants · doi:10.3390/antiox10071084 · Cited by 24 · see citing works

Neuropeptide substance P: A promising regulator of wound healing in diabetic foot ulcers

Chen, J., Ye, P., Gu, R., Zhu, H., He, W., Mu, X., Wu, X., Pang, H., Han, F. Y., & Nie, X. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115736 · Cited by 23 · see citing works

SP prevents T2DM complications by immunomodulation

Baek, S.-M., Kim, K., Kim, S., Son, Y., Hong, H. S., & Yu, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-73994-1 · Cited by 23 · see citing works

Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages

Muschter, D., Beiderbeck, A.-S., Späth, T., Kirschneck, C., Schröder, A., & Grässel, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030503 · Cited by 22 · see citing works

The mTOR kinase inhibitor rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human microglial cells

Cappoli, N., Mezzogori, D., Tabolacci, E., Coletta, I., Navarra, P., Pani, G., & Russo, C. D. (2019) · EXCLI journal · doi:10.17179/excli2019-1715 · Cited by 22 · see citing works

Baccatin III ameliorates bleomycin-induced pulmonary fibrosis via suppression of TGF-β1 production and TGF-β1-induced fibroblast differentiation

Nie, Y., Zhang, D., Qian, F., & Wu, Y. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105696 · Cited by 22 · see citing works

Endogenous Stem Cells in Homeostasis and Aging

Lim, J. E., & Son, Y. (2017) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-017-0097-3 · Cited by 21 · see citing works

Substance P Reduces Infarct Size and Mortality After Ischemic Stroke, Possibly Through the M2 Polarization of Microglia/Macrophages and Neuroprotection in the Ischemic Rat Brain

Ahn, W., Chi, G., Kim, S., Son, Y., & Zhang, M. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01284-7 · Cited by 20 · see citing works

Neuroimmune Circuits in Allergic Diseases

Cai, H., Zhu, X., & Sokol, C. L. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082423-032154 · Cited by 19 · see citing works

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Fehér, J., Élő, Á., István, L., Nagy, Z. Z., Radak, Z. O., Scuderi, G., Artico, M., & Kovács, I. (2022) · GeroScience · doi:10.1007/s11357-022-00620-5 · Cited by 19 · see citing works

The role of the neuronal microenvironment in sensory function and pain pathophysiology

Starobova, H., Alshammari, A., Winkler, I. G., & Vetter, I. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15724 · Cited by 19 · see citing works

The roles of the nerve-immune axis in modulating bone regeneration

Zhao, Y., Xu, K., Wu, K., Guo, Z., Li, H., Lin, N., Ye, Z., Huang, X., Xu, J., & Huang, D. (2026) · Bone Research · doi:10.1038/s41413-025-00476-3 · Cited by 18 · see citing works

Neuropeptides SP and CGRP Diminish theMoraxella catarrhalisOuter Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils

Augustyniak, D., Roszkowiak, J., Wiśniewska, I., Skała, J., Gorczyca, D., & Drulis‐Kawa, Z. (2018) · Mediators of Inflammation · doi:10.1155/2018/4847205 · Cited by 18 · see citing works

Sutureless neurorrhaphy system using a macrophage-polarizing in situ visible light-crosslinkable adhesive protein hydrogel for functional nerve regeneration

Cheong, H., Jun, Y. J., Jeon, E. Y., Lee, J. I., Jo, H. J., Park, H., Kim, E., Rhie, J. W., Joo, K. I., & Chi, H. J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.136641 · Cited by 18 · see citing works

The Yin/Yang Balance of Communication between Sensory Neurons and Macrophages in Traumatic Peripheral Neuropathic Pain

Gheorghe, R., Grosu, A. V., Bica-Popi, M., & Ristoiu, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012389 · Cited by 18 · see citing works

The neural niche in cancer: mechanistic insights into tumor–neuron–immune crosstalk and therapeutic opportunities

Ayşit, N., Altintas, E., Alkan, F. K., Öztürk, G., & Körkaya, H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1667459 · Cited by 17 · see citing works

Panax notoginseng Saponins Regulate Macrophage Polarization under Hyperglycemic Condition via NF-κB Signaling Pathway

Zhao, Y., Zheng, J., Yu, Y., & Wang, L. (2018) · BioMed Research International · doi:10.1155/2018/9239354 · Cited by 17 · see citing works

Mechanical loading and orthobiologic therapies in the treatment of post-traumatic osteoarthritis (PTOA): a comprehensive review

Gardashli, M., Baron, M., Huang, C. ‐. C., Kaplan, L. D., Meng, Z., Kouroupis, D., & Best, T. M. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1401207 · Cited by 15 · see citing works

Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response

Kim, D.-J., Moon, J.-Y., Kim, S.-M., Seo, J.-W., Lee, Y. H., Jung, S. W., Kim, K., Kim, Y., Lim, S., Lee, S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00600 · Cited by 15 · see citing works

Ropivacaine Promotes Axon Regeneration by Regulating Nav1.8-mediated Macrophage Signaling after Sciatic Nerve Injury in Rats

Cui, Y., Wang, X., Xu, Y., Cao, Y., Luo, G., Zhao, Z., & Zhang, J. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004761 · Cited by 14 · see citing works

Substance P regulates memory Th17 cell generation and maintenance in chronic dry eye disease

Wang, S., Naderi, A., Kahale, F., Ortiz, G., Forouzanfar, K., Chen, Y., & Dana, R. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae142 · Cited by 14 · see citing works

Docosahexaenoic acid induces changes in microglia/macrophage polarization after spinal cord injury in rats

Manzhulo, O. S., Tyrtyshnaia, A. A., Kipryushina, Y. O., Dyuizen, I. V., & Manzhulo, I. (2018) · Acta Histochemica · doi:10.1016/j.acthis.2018.08.005 · Cited by 14 · see citing works

Substance-P Restores Cellular Activity of ADSC Impaired by Oxidative Stress

Park, J. S., Piao, J., Park, G., & Hong, H. S. (2020) · Antioxidants · doi:10.3390/antiox9100978 · Cited by 14 · see citing works

SP protects Nile tilapia (Oreochromis niloticus) against acute Streptococcus agalatiae infection

Li, Q., Jiang, B., Zhang, Z., Huang, Y., Xu, Z., Chen, X., Huang, Y., & Jian, J. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.03.002 · Cited by 14 · see citing works

Substance P modulates BMSCs migration for tissue repair through NK-1R/CXCR4/p-Akt signal activation

Tao, R., Qu, Z., Zhang, K., Chen, J., Wang, X., & Deng, Y. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07044-y · Cited by 13 · see citing works

Control of myeloid cell functions by nociceptors

Hanč, P., Messou, M.-A., Wang, Y., & von Andrian, U. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127571 · Cited by 13 · see citing works

Osteoporotic Bone Regeneration via Plenished Biomimetic PLGA Scaffold with Sequential Release System

Lee, J., Kim, D., Park, S., Jung, J., Baek, S., Lee, S., Kim, J. H., Ahn, T., & Han, D. K. (2023) · Small · doi:10.1002/smll.202310734 · Cited by 13 · see citing works

Macrophage: A key player in neuropathic pain

Ye, Y., Cheng, H., Wang, Y., Sun, Y., Zhang, L., & Tang, J. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2344170 · Cited by 13 · see citing works

An active marine halophenol derivative attenuates lipopolysaccharide-induced acute liver injury in mice by improving M2 macrophage-mediated therapy

Yang, F., Cai, H.-H., Zhang, X., Sun, J., Feng, X., Yuan, H., Zhang, X., Xiao, B., & Li, Q. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107676 · Cited by 13 · see citing works

A novel marine halophenol derivative attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via activating phosphoinositide 3-kinase/Akt pathway

Yang, F., Cai, H.-H., Feng, X., & Li, Q. (2020) · Pharmacological Reports · doi:10.1007/s43440-019-00018-9 · Cited by 12 · see citing works

Members of the CUGBP Elav‐like family of RNA‐binding proteins are expressed in distinct populations of primary sensory neurons

Grlickova‐Duzevik, E., Reimonn, T. M., Michael, M., Tian, T. M., Owyoung, J. N., McGrath‐Conwell, A., Neufeld, P., Mueth, M. G., Molliver, D. C., Ward, P. J., et al. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25520 · Cited by 11 · see citing works

Substance P Increases STAT6-Mediated Transcription Activation of Lymphocyte Cytosolic Protein 2 to Sustain M2 Macrophage Predominance in Pediatric Asthma

Li, M., Zhong, X., & Xu, W. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.11.003 · Cited by 11 · see citing works

The Neurokinin-1 Receptor: A Promising Antitumor Target

Coveñas, R., Rodriguez, F. D., & Muñoz, M. (2022) · Receptors · doi:10.3390/receptors1010005 · Cited by 10 · see citing works

Radiotherapy Plus the Neurokinin-1 Receptor Antagonist Aprepitant: A Potent Therapeutic Strategy for the Treatment of Diffuse Intrinsic Pontine Glioma

Muñoz, M., & Rosso, M. (2025) · Cancers · doi:10.3390/cancers17030520 · Cited by 9 · see citing works

Insights into the mechanisms of angiogenesis in hepatoblastoma

Kong, M., Zhai, Y., Liu, H., Zhang, S., Chen, D., Li, W., Ma, X., & Ji, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1535339 · Cited by 9 · see citing works

Nociceptor–Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain

Menon, N., & Kishen, A. (2023) · Biomolecules · doi:10.3390/biom13081193 · Cited by 9 · see citing works

Association of Neurokinin-1 Receptor Signaling Pathways with Cancer

Rodriguez, F. D., & Coveñas, R. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230818110812 · Cited by 9 · see citing works

Causal relationship between inflammatory factors and gynecological cancer: a Bayesian Mendelian randomization study

Dang, C., Liu, M., Liu, P., Liu, J., Yu, X., Dong, Y., & Zhao, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-80747-x · Cited by 9 · see citing works

Transcription factor specificity protein 1 modulates TGFβ1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P

Yamaguchi, R., Sakamoto, A., Yamaguchi, R., Haraguchi, M., 楢原, 真., Sugiuchi, H., & Yamaguchi, Y. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.011 · Cited by 9 · see citing works

Functional Assessment of Genetically Modified Infrapatellar Fat Pad Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles (EVs): Potential Implications for Inflammation/Pain Reversal in Osteoarthritis

Liebmann, K., Castillo, M., Jergova, S., Rahimi, B., Kaplan, L. D., Best, T. M., Sagen, J., & Kouroupis, D. (2025) · Cells · doi:10.3390/cells14241952 · Cited by 8 · see citing works

Inhibition of mTOR in bovine monocyte derived macrophages and dendritic cells provides a potential mechanism for postpartum immune dysfunction in dairy cows

Sipka, A. S., Chandler, T. L., Weichhart, T., Schuberth, H., & Mann, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-19295-1 · Cited by 8 · see citing works

PEGylated substance P augments therapeutic angiogenesis in diabetic critical limb ischemia

Park, H., Kim, S., Jeon, E. J., Song, I. T., Lee, H., Son, Y., Hong, H. S., & Cho, S. (2019) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2019.05.030 · Cited by 8 · see citing works

Substance P blocks β-aminopropionitrile-induced aortic injury through modulation of M2 monocyte-skewed monocytopoiesis

Piao, J., Park, J. S., Hwang, D. Y., Hong, H. S., & Son, Y. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.005 · Cited by 8 · see citing works

Peptide TK-HR from the Skin of Chinese Folk Medicine Frog Hoplobatrachus Rugulosus Accelerates Wound Healing via the Activation of the Neurokinin-1 Receptor

Wu, J., Xiong, W., Li, J., Liao, H., Chai, J., Huang, X., Lai, S., Kozlov, S. A., Chu, X., & Xu, X. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01434 · Cited by 7 · see citing works

The neuro-cutaneous axis: the role of nerve cells in wound healing

Zhou, Y., Yang, J., Chen, L., Yu, Q., & Yang, Y. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.153038 · Cited by 6 · see citing works

ID: 25

Lim, J. E., Chung, E., & Son, Y. (2015) · Cytokine · doi:10.1016/j.cyto.2015.08.055

Substance P induces M2-type macrophages after spinal cord injury

Jiang, M., Chung, E., Chi, G. F., Ahn, W., Lim, J. E., Hong, H. S., Kim, D., Choi, H., Kim, J., & Son, Y. (2012) · Neuroreport · doi:10.1097/wnr.0b013e3283572206 · Cited by 119 · see citing works

Role of Protein Kinase C and Phosphoinositide 3‐Kinase‐Akt in Substance P‐Induced Proinflammatory Pathways in Mouse Macrophages

Bhatia, M., & Sun, J. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.762.2 · Cited by 1 · see citing works

Substance P Diminishes Lipopolysaccharide and Interferon-γ-Induced TGF-β1 Production by Cultured Murine Macrophages

Marriott, I., & Bost, K. L. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1248 · Cited by 65 · see citing works

Neural stem cells induce M2 polarization of macrophages through the upregulation of interleukin‑4

Ji, Z., Jiang, X., Li, Y., Song, J., Chai, C., & Lu, X. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9277 · Cited by 21 · see citing works