The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Defective Endogenous Pain Modulation in Fibromyalgia: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation Paradigms
Open accessAbstract
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for studies using TS or CPM comparing FM patients with healthy controls. We computed Hedges' g, risk of bias, sensitivity analysis, and meta-regression tests with 10,000 Monte-Carlo permutations. Twenty-three studies (625 female and 23 male FM patients and 591 female and 81 male healthy controls) were included. The meta-analyses showed an effect size of .53 for TS (P < .001; 95% confidence interval = .23-.83), which is a 68% relative difference between patients and controls, and of .57 for CPM (P < .001; 95% confidence interval = -.88 to -.26), representing a 65% relative difference between the groups. The qualitative analyses revealed large heterogeneity between study protocols. Although studies were of low risk of bias, lack of blinding was substantial. Sensitivity analysis and meta-regression identified type and site of stimulation, age, lab, sample size, and medication control as important sources of between-study variability. We showed a significant alteration of pain modulation mechanisms in FM patients. PERSPECTIVE This novel meta-analysis provides evidence for defective endogenous pain modulation in FM patients. We explored the effect of covariates on between-study variability in these paradigms. These biomarkers may aid in diagnosis, and treatment of patients. However, validation requires further investigation under strict methodological settings, and into individual patient covariates.
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Controlling the risk of spurious findings from meta-regression
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Worldwide epidemiology of fibromyalgia
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Reliability of conditioned pain modulation: a systematic review
Kennedy, D. L., Kemp, H. I., Ridout, D., Yarnitsky, D., & Rice, A. S. C. (2016) · Pain · doi:10.1097/j.pain.0000000000000689 · Cited by 456
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Influences of gender role and anxiety on sex differences in temporal summation of pain
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Pain relief through expectation supersedes descending inhibitory deficits in fibromyalgia patients
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Metadata
- Authors
- O'Brien, A. T., Deitos, A., Triñanes Pego, Y., Fregni, F., & Carrillo-de-la-Peña, M. T.
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 19
- Issue
- 8
- Pages
- 819-836
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W2790266628
- Cited by
- 227
- References
- 11
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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