Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables
Abstract
Laboratory pain research has been criticized as being irrelevant to the clinical experience of pain. Previous findings have been inconsistent with some studies suggesting that experimental pain responses may be related to the reported presence or severity of chronic pain, while others report no such associations. However, few of these studies assess a variety of laboratory pain responses, and none has assessed relationships between clinical pain and diffuse noxious inhibitory controls (DNIC) in healthy subjects. We administered questionnaire measures of pain, quality of life, and psychological variables to a sample of healthy adults participating in a laboratory study of age differences in pain responses. DNIC was not related to other laboratory pain responses, psychological variables, or physiological variables measured in the present study. Regression models predicting health-related quality of life (e.g. pain, physical functioning) revealed that age, sex, and DNIC responses explained between 10 and 25% of the variance in these dependent measures. Of the laboratory pain variables, only DNIC was the sole consistent predictor of clinical pain and physical health, with greater DNIC responses related to less pain, better physical functioning, and better self-rated health. In addition, age differences in DNIC appeared to partially mediate age differences in physical functioning. These findings highlight the potential clinical relevance of experimental pain procedures and suggest that DNIC may be the laboratory pain response most closely associated with clinical pain and health-related variables.
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From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [87]
Cites
(1992) · PubMed · Cited by 33,716 · see citing works
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
Pearlin, L. I., Menaghan, E. G., Lieberman, M. A., & Mullan, J. T. (1981) · Journal of Health and Social Behavior · doi:10.2307/2136676 · Cited by 6,289 · cited 2× · see citing works
“The seven-item SOM scale (Pearlin et al., 1981) was used to assess respondents’ general sense of life control and mastery.”
MethodDevelopment of the multidimensional health locus of control (MHLC) scales
Wallston, K. A., Strudler Wallston, B., & DeVellis, R. (1978) · Health Education Monographs · doi:10.1177/109019817800600107 · Cited by 3,373 · cited 2× · see citing works
“Multidimensional health locus of control (MHLC) The MHLC (Wallston et al., 1978) is an 18-item instrument assessing three dimensions of health-specific locus of control.”
MethodBonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,533 · see citing works
Salivary cortisol in psychoneuroendocrine research: recent developments and applications
Kirschbaum, C., & Hellhammer, D. H. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90013-2 · Cited by 2,107 · see citing works
Salivary Cortisol in Psychobiological Research: An Overview
Kirschbaum, C., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000118611 · Cited by 1,532 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · cited 1× · see citing works
“Relative to controls, patients with fibromyalgia (FM; Hurtig et al., 2001), whiplash (Kasch et al., 2001), headache (Bendtsen, 2000), temporomandibular disorder (TMD; Svensson et al., 2001), and irritable bowel syndrome (Whitehead et al., 2002) show enhanced pain sensitivity.”
BackgroundPrevalence of chronic benign pain disorder among adults: a review of the literature
Verhaak, P. F. M., Kerssens, J. J., Dekker, J., Sorbi, M. J., & Bensing, J. M. (1998) · Pain · doi:10.1016/s0304-3959(98)00117-1 · Cited by 743 · see citing works
Central Sensitization in Tension-Type Headache—Possible Pathophysiological Mechanisms
Bendtsen, L. (2000) · Cephalalgia · doi:10.1046/j.1468-2982.2000.00070.x · Cited by 593 · see citing works
Possible Deficiencies of Pain Modulation in Fibromyalgia
Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546 · see citing works
Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539 · see citing works
Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476 · see citing works
The epidemiology of pain in elderly people
Helme, R. D., & Gibson, S. J. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70078-1 · Cited by 451 · see citing works
Age-related differences in pain perception and report
Gibson, S. J., & Helme, R. D. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70079-3 · Cited by 432 · see citing works
Social Psychology of Health and Illness
Sanders, G. S., & Suls, J. M. (2013) · Psychology Press eBooks · doi:10.4324/9780203762967 · Cited by 386 · see citing works
Motivation, emotion, and personality
SPENCE, J. T., & Izard, C. E. (1985) · Elsevier eBooks · Cited by 373 · see citing works
Ethnic Differences in Pain Tolerance: Clinical Implications in a Chronic Pain Population
Edwards, R. R., Doleys, D. M., Fillingim, R. B., & Lowery, D. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200103000-00018 · Cited by 358 · see citing works
Self-citationEdwards, R. R., Fillingim, R. B., & Ness, T. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00324-x · Cited by 356 · see citing works
Self-citationChronic pain in elderly people
Gagliese, L., & Melzack, R. (1997) · Pain · doi:10.1016/s0304-3959(96)03266-6 · Cited by 334 · see citing works
Ware, J. E., Kosinski, M. R., & Keller, S. (1990) · Cited by 312 · see citing works
Sex differences in temporal summation but not sensory-discriminative processing of thermal pain
Fillingim, R. B., Maixner, W., Kincaid, S., & Silva, S. (1998) · Pain · doi:10.1016/s0304-3959(97)00214-5 · Cited by 289 · see citing works
Self-citationMulti-method assessment of experimental and clinical pain in patients with fibromyalgia
Lautenbacher, S., Rollman, G. B., & McCain, G. A. (1994) · Pain · doi:10.1016/0304-3959(94)90046-9 · Cited by 270 · see citing works
Optimism, self-mastery, and symptoms of depression in women professionals.
Marshall, G. N., & Lang, E. L. (1990) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.59.1.132 · Cited by 259 · see citing works
Optimism, self-mastery, and symptoms of depression in women professionals.
Marshall, G. N., & Lang, E. L. (1990) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.59.1.132 · Cited by 259 · see citing works
Washington, L. L., Gibson, S. J., & Helme, R. D. (2000) · Pain · doi:10.1016/s0304-3959(00)00352-3 · Cited by 223 · see citing works
The relationship of sex and clinical pain to experimental pain responses
Fillingim, R. B., Edwards, R. R., & Powell, T. (1999) · Pain · doi:10.1016/s0304-3959(99)00128-1 · Cited by 223 · see citing works
Self-citationEthnic Differences in Thermal Pain Responses
Edwards, R. R., & Fillingim, R. B. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199905000-00014 · Cited by 221 · see citing works
Self-citationHu, J. W. (1990) · Pain · doi:10.1016/0304-3959(90)90010-b · Cited by 202 · see citing works
Pain Sensitivity as a Correlate of Clinical Status in Individuals With Chronic Low Back Pain
Clauw, D. J., Williams, D. A., Lauerman, W. C., Dahlman, M., Aslami, A., NACHEMSON, A. L., Kobrine, A. I., & Wiesel, S. W. (1999) · Spine · doi:10.1097/00007632-199910010-00013 · Cited by 191 · see citing works
Edwards, R. R., & Fillingim, R. B. (2001) · Journal of Pain · doi:10.1054/jpai.2001.25525 · Cited by 189 · see citing works
Self-citationDiffuse noxious inhibitory controls in man: Involvement of an opioidergic link
Willer, J. C., Bars, D. L., & de Broucker, T. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90293-f · Cited by 186 · see citing works
Hurtig, I., Raak, R., Kendall, S., Gerdle, B., & Wahren, L. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200112000-00005 · Cited by 177 · see citing works
Analysis of stimulus-evoked pain in patients with myofascial temporomandibular pain disorders
Svensson, P. J., List, T., & Hector, G. (2001) · Pain · doi:10.1016/s0304-3959(01)00284-6 · Cited by 157 · see citing works
Adrenocortical and hemodynamic predictors of pain perception in men and women
Al’Absi, M., Petersen, K. L., & Wittmers, L. E. (2002) · Pain · doi:10.1016/s0304-3959(01)00447-x · Cited by 154 · see citing works
Age-Associated Differences in Responses to Noxious Stimuli
Edwards, R. R., & Fillingim, R. B. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.3.m180 · Cited by 144 · see citing works
Self-citationGibson, S. J., Katz, B., Corran, T. M., Farrell, M. J., & Helme, R. D. (1994) · Disability and Rehabilitation · doi:10.3109/09638289409166289 · Cited by 142 · see citing works
Price, D. D., & McHaffie, J. G. (1988) · Pain · doi:10.1016/0304-3959(88)90119-4 · Cited by 125 · see citing works
Endogenous mechanisms of sensory modulation
Dubner, R. A., & Ren, K. (1999) · Pain · doi:10.1016/s0304-3959(99)00137-2 · Cited by 118 · see citing works
Fillingim, R. B., Maixner, W. D., Kincaid, S., Sigurðsson, Á., & Harris, M. B. (1996) · Clinical Journal of Pain · doi:10.1097/00002508-199612000-00005 · Cited by 106 · see citing works
Self-citationPienimäki, T., Tarvainen, T. K., Siira, P. T., Malmivaara, A. V., & Vanharanta, H. V. (2002) · Clinical Journal of Pain · doi:10.1097/00002508-200205000-00005 · Cited by 93 · see citing works
Pain Thresholds and Tenderness in Neck and Head Following Acute Whiplash Injury: A Prospective Study
Kasch, H., Stengaard‐Pedersen, K., Arendt‐Nielsen, L., & Jensen, T. S. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00179.x · Cited by 92 · see citing works
Measuring Ankle Systolic Blood Pressure: Validation of the Dinamap 1846 SX
Mundt, K. A., Chambless, L. E., Burnham, C. B., & HEISS, G. M. (1992) · Angiology · doi:10.1177/000331979204300703 · Cited by 77 · see citing works
The encoding of thermal stimuli by diffuse noxious inhibitory controls (DNIC)
Bars, D. L., Chitour, D., & Clot, A. M. (1981) · Brain Research · doi:10.1016/0006-8993(81)90422-4 · Cited by 77 · see citing works
Effects of experimental and clinical noxious counterirritants on pain perception
Sigurðsson, Á., & Maixner, W. D. (1994) · Pain · doi:10.1016/0304-3959(94)90002-7 · Cited by 72 · see citing works
Reactivity and response to pain
Dubreuil, D. L., & Kohn, P. M. (1986) · Personality and Individual Differences · doi:10.1016/0191-8869(86)90093-0 · Cited by 66 · see citing works
Mostofsky, D. I., & Lomranz, J. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0283-2 · Cited by 58 · see citing works
Neuroendocrinology of Aging in the Male and Female
Urban, R. J. (1992) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30195-6 · Cited by 48 · see citing works
Cadden, S. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90938-j · Cited by 33 · see citing works
Dewhurst, G., Wood, D. A., Walker, F., Lampe, F. C., JEFFREYS, M., Cooper, M. E., & Williams, J. D. (1991) · Age and Ageing · doi:10.1093/ageing/20.5.353 · Cited by 31 · see citing works
Experimental pain sensitivity and reports of negative thoughts in adults with sickle cell disease
Gil, K. M., Phillips, G., Webster, D. A., Martin, N. J., Abrams, M. A., Grant, M. M., Clark, W. C., & Janal, M. N. (1995) · Behavior Therapy · doi:10.1016/s0005-7894(05)80106-6 · Cited by 29 · see citing works
Sheps, D. S., McMahon, R. P., Light, K. C., Maixner, W. D., Pepine, C. J., Cohen, J. D., Goldberg, A. D., Bonsall, R. W., Carney, R. M., Stone, P. H., et al. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00099-6 · Cited by 26 · see citing works
Pain and Psychological Function in Late Life
Parmelee, P. A. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0283-2_10 · Cited by 22 · see citing works
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Sex, gender, and pain: a review of recent clinical and experimental findings
Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B., & Riley, J. L. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2008.12.001 · Cited by 2,766 · see citing works
Self-citationPrediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750 · see citing works
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Self-citationConditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
Yarnitsky, D., Granot, M., Nahman‐Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012) · Pain · doi:10.1016/j.pain.2012.02.021 · Cited by 561 · see citing works
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548 · see citing works
Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions
Chapman, C. R., Tuckett, R. P., & Song, C. W. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.006 · Cited by 541 · see citing works
The effects of sleep deprivation on pain inhibition and spontaneous pain in women
Smith, M. T., Edwards, R. R., McCann, U. D., & Haythornthwaite, J. A. (2007) · Sleep · doi:10.1093/sleep/30.4.494 · Cited by 539 · see citing works
Self-citationReliability of conditioned pain modulation: a systematic review
Kennedy, D. L., Kemp, H. I., Ridout, D., Yarnitsky, D., & Rice, A. S. C. (2016) · Pain · doi:10.1097/j.pain.0000000000000689 · Cited by 456 · see citing works
Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.06.029 · Cited by 371 · see citing works
Ruscheweyh, R., Marziniak, M., Stumpenhorst, F., Reinholz, J., & Knecht, S. (2009) · Pain · doi:10.1016/j.pain.2009.06.020 · Cited by 364 · see citing works
Guidelines for the understanding and management of pain in chronic pancreatitis
Drewes, A. M., Bouwense, S. A. W., Campbell, C. M., Ceyhan, G. O., Delhaye, M., Demir, I. E., Garg, P. K., van Goor, H., Halloran, C., Isaji, S., et al. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.006 · Cited by 321 · see citing works
Nir, R., & Yarnitsky, D. (2015) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000126 · Cited by 317 · see citing works
Ethnic differences in responses to multiple experimental pain stimuli
Campbell, C. M., Edwards, R. R., & Fillingim, R. B. (2005) · Pain · doi:10.1016/j.pain.2004.08.013 · Cited by 302 · see citing works
Self-citationAbnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions
Staud, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.41 · Cited by 290 · see citing works
Individual differences in endogenous pain modulation as a risk factor for chronic pain
Edwards, R. R. (2005) · Neurology · doi:10.1212/01.wnl.0000171862.17301.84 · Cited by 283 · see citing works
Self-citationKing, C. D., Wong, F., Currie, T., Mauderli, A. P., Fillingim, R. B., & Riley, J. L. (2009) · Pain · doi:10.1016/j.pain.2008.12.027 · Cited by 284 · see citing works
Self-citationvan Wijk, G., & Veldhuijzen, D. S. (2010) · The Journal of Pain · doi:10.1016/j.jpain.2009.10.009 · Cited by 281 · see citing works
Sex and gender differences in pain and analgesia
Mogil, J. S., & Bailey, A. L. (2010) · Progress in brain research · doi:10.1016/b978-0-444-53630-3.00009-9 · Cited by 269 · see citing works
Edwards, R. R., Haythornthwaite, J. A., Sullivan, M. J., & Fillingim, R. B. (2004) · Pain · doi:10.1016/j.pain.2004.07.012 · Cited by 250 · see citing works
Self-citationO’Brien, A. T., Deitos, A., Pego, Y. T., Fregni, F., & Carrillo‐de‐la‐Peña, M. T. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.01.010 · Cited by 225 · see citing works
Wilder‐Smith, O. H. G., & Arendt‐Nielsen, L. (2006) · Anesthesiology · doi:10.1097/00000542-200603000-00028 · Cited by 219 · see citing works
Effects of catastrophizing on pain perception and pain modulation
Weissman-Fogel, I., Sprecher, E., & Pud, D. (2008) · Experimental Brain Research · doi:10.1007/s00221-007-1206-7 · Cited by 214 · see citing works
Prolonged pain and disability are common after rib fractures
Fabricant, L. J., Ham, B., Mullins, R. J., & Mayberry, J. C. (2013) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2012.12.007 · Cited by 200 · see citing works
Review: Central pain mechanisms in the rheumatic diseases: Future directions
Phillips, K., & Clauw, D. J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37739 · Cited by 194 · see citing works
Quantitative assessment of experimental pain perception: multiple domains of clinical relevance
Edwards, R. R., Sarlani, E., Wesselmann, U., & Fillingim, R. B. (2005) · Pain · doi:10.1016/j.pain.2005.01.007 · Cited by 187 · see citing works
Self-citationAssociations Between Catastrophizing and Endogenous Pain-Inhibitory Processes: Sex Differences
Goodin, B. R., McGuire, L. M., Allshouse, M., Stapleton, L. M., Haythornthwaite, J. A., Burns, N., Mayes, L. A., & Edwards, R. R. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.08.012 · Cited by 185 · see citing works
Self-citationAn experimental model to measure excitatory and inhibitory pain mechanisms in humans
Tousignant-Laflamme, Y., Pagé, S., Goffaux, P., & Marchand, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.120 · Cited by 182 · see citing works
Wilder‐Smith, O. H. G., Schreyer, T., Scheffer, G. J., & Arendt‐Nielsen, L. (2010) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360281003706069 · Cited by 177 · see citing works
Central Nervous System Reorganization in a Variety of Chronic Pain States: A Review
Henry, D. E., Chiodo, A. E., & Yang, W. (2011) · PM&R · doi:10.1016/j.pmrj.2011.05.018 · Cited by 172 · see citing works
Diagnosing and treating chronic musculoskeletal pain based on the underlying mechanism(s)
Clauw, D. J. (2015) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2015.04.024 · Cited by 169 · see citing works
‘Pain inhibits pain’ mechanisms: Is pain modulation simply due to distraction?
Moont, R., Pud, D., Sprecher, E., Sharvit, G., & Yarnitsky, D. (2010) · Pain · doi:10.1016/j.pain.2010.04.009 · Cited by 169 · see citing works
The Physiology of Pain Mechanisms: From the Periphery to the Brain
Marchand, S. (2008) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2008.04.003 · Cited by 165 · see citing works
Differential endogenous pain modulation in complex-regional pain syndrome
Seifert, F. C., Kiefer, G., DeCol, R., Schmelz, M., & Maihöfner, C. (2009) · Brain · doi:10.1093/brain/awn346 · Cited by 161 · see citing works
Functional Abdominal Pain Syndrome
Clouse, R. E., Mayer, E. A., Aziz, Q., Drossman, D. A., Dumitrascu, D. L., Mönnikes, H., & Naliboff, B. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.062 · Cited by 158 · see citing works
Edwards, R. R., Grace, E., Peterson, S., Klick, B., Haythornthwaite, J. A., & Smith, M. T. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2008.12.007 · Cited by 158 · see citing works
Self-citationWilder‐Smith, C. H. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i27.3699 · Cited by 156 · see citing works
Nir, R., Granovsky, Y., Yarnitskyl, D., Sprecherl, E., & Granot, M. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.10.001 · Cited by 154 · see citing works
Physical activity behavior predicts endogenous pain modulation in older adults
Naugle, K. M., Ohlman, T., Naugle, K. E., Riley, Z. A., & Keith, N. R. (2017) · Pain · doi:10.1097/j.pain.0000000000000769 · Cited by 154 · see citing works
Mechanisms by which sleep disturbance contributes to osteoarthritis pain: A conceptual model
Smith, M. T., Quartana, P. J., Okonkwo, R., & Nasir, A. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0073-2 · Cited by 152 · see citing works
Effects of diffuse noxious inhibitory controls on temporal summation of the RIII reflex in humans
Serrao, M., Rossi, P., Sandrini, G., Parisi, L., Amabile, G. A., Nappi, G., & Pierelli, F. (2004) · Pain · doi:10.1016/j.pain.2004.09.018 · Cited by 149 · see citing works
The role of sleep problems in central pain processing in rheumatoid arthritis
Lee, Y., Lü, B., Edwards, R. R., Wasan, A. D., Nassikas, N. J., Clauw, D. J., Solomon, D. H., & Karlson, E. W. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37733 · Cited by 142 · see citing works
Self-citationDamien, J., Colloca, L., Belleï-Rodriguez, C.-É., & Marchand, S. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.024 · Cited by 142 · see citing works
Tan, E.-C., Lim, E. C., Teo, Y.-Y., Lim, Y., Law, H.-Y., & Sia, A. T. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-32 · Cited by 133 · see citing works
The common link between functional somatic syndromes may be central sensitisation
Bourke, J. H., Langford, R. M., & White, P. D. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.01.003 · Cited by 124 · see citing works
Stein, N., Sprenger, C., Scholz, J., Wiech, K., & Bingel, U. (2012) · Pain · doi:10.1016/j.pain.2012.07.010 · Cited by 116 · see citing works
Cognitive-Behavioral Therapy for Comorbid Insomnia and Chronic Pain
Finan, P. H., Buenaver, L. F., Runko, V. T., & Smith, M. T. (2014) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.02.007 · Cited by 117 · see citing works
Ethnic differences in diffuse noxious inhibitory controls
Campbell, C. M., France, C. R., Robinson, M. E., Logan, H. L., Geffken, G. R., & Fillingim, R. B. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2008.03.010 · Cited by 113 · see citing works
Self-citationThe Influence of Menstrual Phases on Pain Modulation in Healthy Women
Rezaii, T., Hirschberg, A. L., Carlström, K., & Ernberg, M. M. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.04.002 · Cited by 112 · see citing works
Hackett, J., Naugle, K. E., & Naugle, K. M. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.09.005 · Cited by 112 · see citing works
Stress and tension-type headache mechanisms
Cathcart, S., Winefield, A. H., Lushington, K., & Rolan, P. E. (2010) · Cephalalgia · doi:10.1177/0333102410362927 · Cited by 108 · see citing works
Wickwire, E. M., Schnyer, D. M., Germain, A., Smith, M. T., Williams, S. G., Lettieri, C. J., McKeon, A. B., Scharf, S. M., Stocker, R., Albrecht, J. S., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5243 · Cited by 106 · see citing works
A Subgroup of Chronic Low Back Pain Patients With Central Sensitization
Aoyagi, K., He, J., Chadwick, A. L., Clauw, D. J., Kluding, P. M., Jernigan, S. D., & Sharma, N. K. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000755 · Cited by 107 · see citing works
Noxious Inhibition of Temporal Summation is Impaired in Chronic Tension‐Type Headache
Cathcart, S., Winefield, A. H., Lushington, K., & Rolan, P. E. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01545.x · Cited by 102 · see citing works
Edwards, R. R., Campbell, C. M., & Fillingim, R. B. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.02.013 · Cited by 99 · see citing works
Self-citationSex differences in endogenous pain modulation by distracting and painful conditioning stimulation
Quiton, R. L., & Greenspan, J. D. (2007) · Pain · doi:10.1016/j.pain.2007.09.001 · Cited by 98 · see citing works
Tesarz, J., Gerhardt, A., Schommer, K., Treede, R., & Eich, W. (2013) · Pain · doi:10.1016/j.pain.2013.03.014 · Cited by 97 · see citing works
Nir, R., Yarnitsky, D., Honigman, L., & Granot, M. (2011) · Pain · doi:10.1016/j.pain.2011.10.010 · Cited by 97 · see citing works
Cortical influences on brainstem circuitry responsible for conditioned pain modulation in humans
Youssef, A. M., Macefield, V. G., & Henderson, L. A. (2016) · Human Brain Mapping · doi:10.1002/hbm.23199 · Cited by 95 · see citing works
Homotopic and heterotopic effects of endogenous analgesia in healthy volunteers
Pud, D., Sprecher, E., & Yarnitsky, D. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.037 · Cited by 94 · see citing works
Grosen, K., Vase, L., Pilegaard, H. K., Pfeiffer‐Jensen, M., & Drewes, A. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090185 · Cited by 92 · see citing works
Martel, M. O., Wasan, A. D., & Edwards, R. R. (2013) · Pain Medicine · doi:10.1111/pme.12220 · Cited by 92 · see citing works
Self-citationSex differences in experimental measures of pain sensitivity and endogenous pain inhibition
Goodin, B. R., Bulls, H. W., Freeman, E. L., Robbins, M. T., Anderson, A., & Ness, T. J. (2015) · Journal of Pain Research · doi:10.2147/jpr.s84607 · Cited by 90 · see citing works
Self-citationCentral pain processing is altered in people with Achilles tendinopathy
Tompra, N., van Dieën, J. H., & Coppieters, M. W. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095476 · Cited by 87 · see citing works
Johannesson, U., de Boussard, C. N., Jansen, G. B., & Bohm‐Starke, N. (2006) · Pain · doi:10.1016/j.pain.2006.10.022 · Cited by 84 · see citing works
Heymen, S., Maixner, W., Whitehead, W. E., Klatzkin, R. R., Mechlin, B., & Light, K. C. (2010) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181bff800 · Cited by 82 · see citing works
Goodin, B. R., Glover, T. L., Sotolongo, A. S., King, C. D., Sibille, K. T., Herbert, M. S., Cruz‐Almeida, Y., Sanden, S. H., Staud, R. M., Redden, D. T., et al. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.10.007 · Cited by 83 · see citing works
Self-citationIncreased conditioned pain modulation in athletes
Flood, A. P., Waddington, G. S., Thompson, K., & Cathcart, S. (2016) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1210196 · Cited by 81 · see citing works
Can quantitative sensory testing predict responses to analgesic treatment?
Grosen, K., Fischer, I. W. D., Olesen, A. E., & Drewes, A. M. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00330.x · Cited by 81 · see citing works
Analysis of Meaningful Conditioned Pain Modulation Effect in a Pain-Free Adult Population
Locke, D., Gibson, W., Moss, P., Munyard, K., Mamotte, C. D. S., & Wright, A. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.09.001 · Cited by 81 · see citing works
Ablin, K., & Clauw, D. J. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.06.006 · Cited by 79 · see citing works
Yu, R., Gollub, R. L., Vangel, M. G., Kaptchuk, T. J., Smoller, J. W., & Kong, J. (2014) · Human Brain Mapping · doi:10.1002/hbm.22496 · Cited by 79 · see citing works
Fujii, K., Motohashi, K., & Umino, M. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.07.002 · Cited by 74 · see citing works
Herbert, M. S., Goodin, B. R., Pero, S. T., Schmidt, J. K., Sotolongo, A. S., Bulls, H. W., Glover, T. L., King, C. D., Sibille, K. T., Cruz‐Almeida, Y., et al. (2013) · Annals of Behavioral Medicine · doi:10.1007/s12160-013-9563-x · Cited by 72 · see citing works
Self-citationThe role of stimulation parameters on the conditioned pain modulation response
Nahman‐Averbuch, H., Yarnitsky, D., Granovsky, Y., Gerber, E., Dagul, P., & Granot, M. (2013) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2012.08.001 · Cited by 71 · see citing works
Valencia, C., Fillingim, R. B., & George, S. Z. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.06.002 · Cited by 71 · see citing works
Self-citationTest-Retest Reliability of Thermal Temporal Summation Using an Individualized Protocol
Kong, J., Johnson, K. A., Balise, R. R., & Mackey, S. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.10.010 · Cited by 70 · see citing works
Abnormal Pain Modulation in Patients with Spatially Distributed Chronic Pain: Fibromyalgia
Staud, R. M. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.05.006 · Cited by 70 · see citing works
Functional abdominal pain syndrome
DROSSMAN, D. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00118-1 · Cited by 67 · see citing works
Goodin, B. R., Kronfli, T., King, C. D., Glover, T. L., Sibille, K. T., & Fillingim, R. B. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9411-7 · Cited by 68 · see citing works
Self-citationInvestigation of Central Pain Processing in Postoperative Shoulder Pain and Disability
Valencia, C., Fillingim, R. B., Bishop, M. D., Wu, S. S., Wright, T. W., Moser, M., Farmer, K. W., & George, S. Z. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000029 · Cited by 64 · see citing works
Self-citationVidor, L. P., Torres, I. L. D. S., Medeiros, L. F., Dussán‐Sarria, J. A., Dall’Agnol, L., Deitos, A., Brietzke, A. P., Laste, G., Rozisky, J. R., Fregni, F., et al. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-42 · Cited by 64 · see citing works
Larauche, M. H., Mulak, A., Kim, Y. S., Labus, J. S., Million, M., & Taché, Y. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01980.x · Cited by 60 · see citing works
Lee, J. E., Watson, D., & Law, L. A. F. (2010) · Journal of Pain · doi:10.1016/j.jpain.2009.10.013 · Cited by 61 · see citing works
Treister, R., Eisenberg, E., Gershon, E., Haddad, M., & Pud, D. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2009.10.005 · Cited by 60 · see citing works
Valencia, C., Kindler, L. L., Fillingim, R. B., & George, S. Z. (2013) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-14-182 · Cited by 60 · see citing works
Self-citationWilliams, A. E., Heitkemper, M. M., Self, M. M., Czyzewski, D. I., & Shulman, R. J. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.003 · Cited by 58 · see citing works
An Endogenous Pain Control System is Altered in Subjects with Interstitial Cystitis
Ness, T. J., Lloyd, L. K., & Fillingim, R. B. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.08.024 · Cited by 57 · see citing works
Self-citationde Vries, M., Van Rijckevorsel, D. C. M., Vissers, K. C. P., Wilder‐Smith, O. H. G., & Van Goor, H. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12811 · Cited by 54 · see citing works
Prediction of pain sensitivity in healthy volunteers
Ravn, P., Werner, M. U., Fredriksen, Skovsen, A. P., & Christrup, L. L. (2012) · Journal of Pain Research · doi:10.2147/jpr.s33925 · Cited by 47 · see citing works
Endogenous Pain Modulation Profiles Among Individuals With Chronic Pain: Relation to Opioid Use
Martel, M. O., Petersen, K. K., Cornelius, M. C., Arendt‐Nielsen, L., & Edwards, R. R. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.10.004 · Cited by 47 · see citing works
Self-citationGrinberg, K., Granot, M., Löwenstein, L., Abramov, L., & Weissman‐Fogel, I. (2017) · Pain · doi:10.1097/j.pain.0000000000000869 · Cited by 46 · see citing works
Staudl, R., Robinson, M. E., Goldman, C. T., & Price, D. D. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.01.011 · Cited by 45 · see citing works
Vagal stomach afferents inhibit somatic pain perception
Sedan, O., Sprecher, E., & Yarnitsky, D. (2004) · Pain · doi:10.1016/j.pain.2004.11.012 · Cited by 45 · see citing works
Endogenous Opioids, Blood Pressure, and Diffuse Noxious Inhibitory Controls: A Preliminary Study
Edwards, R. R., Ness, T. J., & Fillingim, R. B. (2004) · Perceptual and Motor Skills · doi:10.2466/pms.99.2.679-687 · Cited by 45 · see citing works
Self-citationMakovac, E., Venezia, A., Hohenschurz-Schmidt, D., Dipasquale, O., Jackson, J. B., Medina, S., O’Daly, O., Williams, S. C., McMahon, S. B., & Howard, M. A. (2021) · The Journal of Physiology · doi:10.1113/jp282013 · Cited by 44 · see citing works
Does Exercise Decrease Pain via Conditioned Pain Modulation in Adolescents?
Stolzman, S. C., & Bement, M. H. (2016) · Pediatric Physical Therapy · doi:10.1097/pep.0000000000000312 · Cited by 44 · see citing works
Heterotopic pruritic conditioning and itch – Analogous to DNIC in pain?
van Laarhoven, A. I. M., Kraaimaat, F. W., Wilder‐Smith, O. H. G., van de Kerkhof, P. C. M., & Evers, A. W. M. (2010) · Pain · doi:10.1016/j.pain.2010.02.026 · Cited by 42 · see citing works
Campbell, C., Boundsl, S. C., Simangol, M. B., Witmerl, K. R., Campbelll, J. N., Edwardsl, R. R., Haythornthwaitel, J. A., & Smithl, M. T. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.11.014 · Cited by 40 · see citing works
Smith, A. D., & Pedler, A. R. (2017) · European Journal of Pain · doi:10.1002/ejp.1093 · Cited by 40 · see citing works
Tavares, D. R. B., Trevisani, V. F. M., Okazaki, J. É. F., Santana, M. V. D. A., Pinto, A. C. P. N., Tutiya, K. K., Gazoni, F. M., Pinto, C. B., Santos, F. C., & Fregni, F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05723 · Cited by 39 · see citing works
- Authors
- Edwards, R. R., Ness, T. J., Weigent, D. A., & Fillingim, R. B.
- Affiliations
- Johns Hopkins University (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- Corresponding author
- Edwards, Robert R
- Venue
- Pain
- Published
- 2003-12
- Volume
- 106
- Issue
- 3
- Pages
- 427-437
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2080207646
- Cited by
- 220
- References
- 55
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 11 · 2013: 17 · 2012: 16
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Alabama at Birmingham
- National Institutes of Health
- National Institute on Drug Abuse (DA 06060)
- National Institute of Dental and Craniofacial Research (DE 12261, R29DE012261)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- diffuse noxious inhibitory control, experimental pain, chronic pain, health-related quality of life, physical function, self-rated health, age differences, sex differences, individual differences
- MeSH terms
- Adult, Age Factors, Aged, Analysis of Variance, Female, Follow-Up Studies, Humans, Individuality, Inhibition, Psychological, Male, Middle Aged, Pain Measurement, Quality of Life, Regression Analysis, Chi-Square Distribution, Pain Threshold
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