Cited by 114Bioactive natural compoundsEssential Oils and Antimicrobial ActivitySesquiterpenes and Asteraceae Studies

Two Flavonols from Artemisa annua which Potentiate the Activity of Berberine and Norfloxacin Against a Resistant Strain of Staphylococcus aureus

Stermitz, Frank R., Scriven, Lacey N., Tegos, George, Lewis, Kim·2002·Planta Medica

Abstract

Bioassay-guided fractionation of an extract of Artemisia annua L. (Asteraceae) was conducted in order to assess the possible presence in the plant material of inhibitors of bacterial multidrug resistance pumps. Fractions were tested for Staphylococcus aureus growth inhibition in the presence of a subinhibitory dose of the weak antibacterial alkaloid berberine. Active fractions yielded the flavones chrysosplenol-D and chrysoplenetin, which themselves had very weak growth inhibitory action, but which made a potent combination with berberine. In comparison with work on other flavonols, it is likely that potentiation is due to the inhibition of an S. aureus multidrug resistance (MDR) pump. These same two flavonols were earlier reported to potentiate the activity of artemisinin against Plasmodium falciparum.

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Crossref · 10.1055/s-2002-36347

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Authors
Stermitz, F. R., Scriven, L. N., Tegos, G., & Lewis, K.
Affiliations
  • Colorado State University (US)
  • Northeastern University (US)
Venue
Planta Medica
Published
2002-12
Volume
68
Issue
12
Pages
1140-1141
ISSN
  • 0032-0943 (ISSN-L)
  • 1439-0221
OpenAlex
W2039587632
Cited by
114
References
0
Citations by year
2026: 1 · 2025: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 9
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Locations
  • Planta Medica (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Colorado State University
  • National Institutes of Health (5r01gm059903-03)
  • National Institute of General Medical Sciences (R01 GM 59903)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
Keywords
Artemisia annua, flavonols, berberine, norfloxacin, Staphylococcus aureus, multidrug resistance, efflux pump inhibitors, bioassay-guided fractionation
MeSH terms
Anti-Infective Agents, Berberine, Drug Synergism, Flavonoids, Norfloxacin, Plant Extracts, Staphylococcus aureus, Molecular Structure, Drug Resistance, Bacterial, Artemisia annua

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