The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Process Analytical Technologies – Advances in bioprocess integration and future perspectives
Open accessAbstract
Process Analytical Technology (PAT) instruments include analyzers capable of measuring physical and chemical process parameters and key attributes with the goal of optimizing process controls. PAT in the form of a probe or sensor is designed to integrate within the pharmaceutical manufacturing line and is coupled with computing equipment to perform chemometric modeling for result interpretation and multilayer statistical control of processes. PAT solutions are intended for understanding bioprocesses with a goal to control quality at all stages of product manufacturing and achieve quality by design (QbD). The goal of PAT implementation is to promote real-time release of products to decrease the cycle time and cost of production. This review focuses on the applications of PAT solutions at different stages of the manufacturing process for vaccine production, the advantages, challenges at present state, and the vision of the future development of biopharmaceutical industries.
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Bioreactor monitoring with spectroscopy and chemometrics: a review
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Enzyme capacity-based genome scale modelling of CHO cells
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Cited by
Bioprocessing 4.0 in Biomanufacturing: Paving the Way for Sustainable Bioeconomy
Pandey, K., Pandey, M., Kumar, V., Aggarwal, U., & Singhal, B. (2024) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-023-00206-y · Cited by 58
Graf, T., Naumann, L., Bonnington, L., Heckel, J., Spensberger, B., Klein, S., Brey, C., Nachtigall, R., Mroz, M., Hogg, T. V., et al. (2024) · Journal of Chromatography A · doi:10.1016/j.chroma.2024.465013 · Cited by 24
In‐Line Monitoring of Protein Concentration With MIR Spectroscopy During UFDF
Milewska, A., Baekelandt, G., Boutaieb, S., Mozin, V., & Falconbridge, A. (2023) · Engineering in Life Sciences · doi:10.1002/elsc.202200050 · Cited by 18
Vaskó, D., Pantea, E., Domján, J., Fehér, C., Mózner, O., Sarkadi, B., Nagy, Z. K., Marosi, G. J., & Hirsch, E. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124251 · Cited by 12
The application of bubble column photobioreactor for algal cultivation
O'Higgins, L., Haider, M. N., Verma, N., & Bose, A. (2025) · Algal Bioreactors · doi:10.1016/b978-0-443-14058-7.00003-8 · Cited by 6
Metadata
- Authors
- Gerzon, G., Sheng, Y., & Kirkitadze, M.
- Venue
- Journal of Pharmaceutical and Biomedical Analysis
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 207
- Pages
- 114379
- ISSN
- 0731-7085 (ISSN-L)
- OpenAlex
- W3203851743
- Cited by
- 176
- References
- 11
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gerzon, G., Sheng, Y., & Kirkitadze, M. (2022). Process Analytical Technologies – Advances in bioprocess integration and future perspectives. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114379
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
