Cited by 457Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

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Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents

Gungor, Neslihan, Saad, Rola, Janosky, Janine, Arslanian, Silva·2004·The Journal of Pediatrics

DOI 10.1016/j.jpeds.2003.09.045

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Abstract

Objectives To compare insulin sensitivity and pancreatic beta-cell function measured by the euglycemic and the hyperglycemic clamp, with simple estimates of insulin sensitivity and pancreatic beta-cell function in youth. Study design We measured insulin sensitivity with a euglycemic clamp and first- and second-phase insulin secretion with a hyperglycemic clamp in 156 AA and white youths. Estimates of insulin sensitivity (fasting insulin level [I(F)], the ratio of fasting glucose [G(F)] to I(F) [G(F)/I(F)], homeostasis model assessment estimate of insulin sensitivity [HOMA IS], and quantitative insulin sensitivity check index [QUICKI]) and estimates of pancreatic beta-cell function (I(F), the ratio of I(F) to G(F) [I(F)/G(F)], and homeostasis model assessment estimate of pancreatic beta-cell function [HOMA %B]) were derived from fasting measurements.Results In the total group, IS(Eu) correlated strongly with I(F) (r=-0.92), G(F)/I(F) (r=0.92), HOMA IS (r=0.91), and QUICKI (r=0.91) (P<.01). First-phase and second-phase insulin secretion correlated with I(F), I(F)/G(F), and HOMA %B (first-phase insulin secretion: r=0.76, 0.79, 0.82; second-phase insulin secretion: r=0.83, 0.86, 0.86, respectively; P<.01).Conclusions Simple estimates of insulin sensitivity and pancreatic beta-cell function using fasting insulin and glucose levels serve as surrogate measures of insulin sensitivity and secretion in nondiabetic youths. The validity of these conclusions in children with impaired glucose tolerance and type 2 diabetes mellitus remains to be determined.

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Authors: Gungor, N., Saad, R., Janosky, J., & Arslanian, S.
Affiliations: University of Pittsburgh (US)
Corresponding author: Arslanian, Silva
ORCID: Arslanian, Silva
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 2004-01
Volume: 144
Issue: 1
Pages: 47-55
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/j.jpeds.2003.09.045
OpenAlex: W2035586426
Cited by: 457
References: 38
Citations by year: 2026: 4 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 14 · 2021: 12 · 2020: 15 · 2019: 21 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 16 · 2014: 27 · 2013: 29 · 2012: 25
FWCI: 35.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (M01-RR-00084, M01RR000084)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01‐HD27503, R01HD027503, K24HD001357, K24 HD1357)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: insulin sensitivity, insulin secretion, beta-cell function, surrogate measures, euglycemic clamp, hyperglycemic clamp, HOMA-IR, QUICKI, fasting insulin, fasting blood glucose, children and adolescents, type 2 diabetes, impaired glucose tolerance
MeSH terms: Adolescent, Blood Glucose, Child, Fasting, Female, Homeostasis, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Obesity, Polycystic Ovary Syndrome, Reproducibility of Results, Glucose Clamp Technique, Linear Models

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Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents

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