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Cited by 57Attention Deficit Hyperactivity DisorderBlood Pressure and Hypertension StudiesPharmacology and Obesity Treatment

Cardiovascular Effects of Longer-Term, High-Dose OROS Methylphenidate in Adolescents with Attention Deficit Hyperactivity Disorder

Hammerness, Paul, Wilens, Timothy, Mick, Eric, Spencer, Thomas, Doyle, Robert, McCreary, Michelle, Becker, Judith, Biederman, Joseph·2009·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2009.02.008
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Abstract

Objective To examine the effects of high doses of extended-release methylphenidate (OROS MPH) on cardiovascular variables in adolescents with attention deficit hyperactivity disorder (ADHD).Study design ECG indices plus systolic blood pressure (SBP), diastolic BP (DBP) and heart rate (HR) were assessed during an open-label study of OROS MPH in 114 adolescents with ADHD (doses up to 1.5 mg/kg/d). Cardiovascular parameters were assessed at 6 weeks and 6 months.Results Small but statistically significant changes in DBP and HR were observed at 6 weeks, without further increases up to 6 months' follow-up. A small but statistically significant increase in SBP was observed over time. Twenty-nine percent of patients had isolated elevations in BP readings prior to study entry, and 14% had >3 consecutive visits at which elevated BP were observed during OROS MPH treatment. No clinically significant changes in ECG parameters were observed. No serious cardiovascular adverse events occurred.Conclusions Treatment with relatively high doses of OROS MPH was associated with small but statistically significant mean increases in BP and HR, primarily during the first 6 weeks of treatment, without clinically meaningful changes in ECG. These observations are consistent with previous reports using lower doses.

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  • Common effects of stimulants on blood pressure, heart rate and exercise parameters are usually of no clinical significance.

    “however, the common effects on blood pressure, heart rate and exercise parameters are usually of no clinical significance [55-57].”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [55]

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Authors
Hammerness, P., Wilens, T., Mick, E., Spencer, T., Doyle, R., McCreary, M., Becker, J., & Biederman, J.
Affiliations
  • Harvard University (US)
  • Massachusetts General Hospital (US)
Corresponding author
Hammerness, Paul
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2009-07
Volume
155
Issue
1
Pages
84-89.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2009.02.008
OpenAlex
W1993782358
Cited by
57
References
28
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 10
FWCI
5.53
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
extended-release methylphenidate, attention deficit hyperactivity disorder, adolescents, cardiovascular effects, blood pressure, heart rate, electrocardiogram, cardiovascular adverse events
MeSH terms
Adolescent, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Blood Pressure, Child, Delayed-Action Preparations, Diastole, Dose-Response Relationship, Drug, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Male, Methylphenidate, Prospective Studies, Systole

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