A Randomized, Placebo-Controlled Trial of OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder
Abstract
Background The objective of this study was to evaluate the safety and efficacy of once-daily OROS methylphenidate (MPH) in the treatment of adults with DSM-IV attention-deficit/hyperactivity disorder (ADHD). Methods We conducted a randomized, 6-week, placebo-controlled, parallel-design study of OROS MPH in 141 adult subjects with DSM-IV ADHD, using standardized instruments for diagnosis. OROS MPH or placebo was initiated at 36 mg/day and titrated to optimal response, depending on efficacy and tolerability, up to 1.3 mg/kg/day. Results Treatment with OROS MPH was associated with clinically and statistically significant reductions in DSM-IV symptoms of inattention and hyperactivity/impulsivity relative to subjects treated with placebo. At endpoint, 66% of subjects (n = 44) receiving OROS MPH and 39% of subjects (n = 29) [corrected] receiving placebo attained our a priori definition of response of much or very much improved on the Clinical Global Impression-Improvement scale plus a >30% reduction in Adult ADHD Investigator System Report Scale score. OROS MPH was associated with small but statistically significant increases in systolic blood pressure (3.5 +/- 11.8 mm Hg), diastolic blood pressure (4.0 +/- 8.5 mm Hg), and heart rate (4.5 +/- 10.5 bpm). Conclusions These results show that treatment with OROS MPH in daily doses of up to 1.3 mg/kg/day was effective in the treatment of adults with ADHD. Because of the potential for increases in blood pressure and heart rate, subjects receiving treatment with MPH should be monitored for changes in blood pressure parameters during treatment.
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Stimulants are effective in about 70% of patients with ADHD in controlled studies, depending on the study design and maximum drug dosage.
“Stimulants are effective in about 70% of patients with ADHD in controlled studies [265-267] depending on the study design and maximum drug dosage.”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [265]
In the United States, more than ten different stimulant preparations have been developed for treatment of ADHD, the most recent being long acting formulations of oros-methylphenidate, mixed amphetamine salts, dexmethylphenidate and lis-dexamphetamine.
“In the United States, more than ten different stimulant preparations have been developed for treatment of ADHD, the most recent being long acting formulations of oros-methylphenidate, mixed amphetamine salts, dexmethylphenidate and lis-dexamphetamine [265,287,288].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [265]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1792 · Cited by 950 · see citing works
Self-citationPharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle
SPENCER, T., BIEDERMAN, J., WILENS, T., HARDING, M., O'DONNELL, D., & GRIFFIN, S. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199604000-00008 · Cited by 830 · see citing works
Self-citationATTENTION-DEFICIT HYPERACTIVITY DISORDER IN ADULTS
Wender, P. H. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70039-3 · Cited by 728 · see citing works
Kessler, R. C., Adler, L. A., Barkley, R., Biederman, J., Conners, C. K., Faraone, S. V., Greenhill, L. L., Jaeger, S., Secnik, K., Spencer, T., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.001 · Cited by 663 · see citing works
Self-citationVariables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD
Volkow, N. D., & Swanson, J. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1909 · Cited by 475 · see citing works
Spencer, T. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950180020004 · Cited by 402 · see citing works
Self-citationSpencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.043 · Cited by 385 · see citing works
Self-citationGender effects on Attention-Deficit/Hyperactivity disorder in adults, revisited
Biederman, J., Faraone, S. V., Monuteaux, M. C., Bober, M., & Cadogen, E. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.003 · Cited by 385 · see citing works
Self-citationDiagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
Wood, D. R., Reimherr, F., Wender, P., & Johnson, G. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120057005 · Cited by 323 · see citing works
Murphy, P., & Schachar, R. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1156 · Cited by 303 · see citing works
Barkley, R. A., DuPaul, G. J., & McMurray, M. B. (1991) · PEDIATRICS · doi:10.1542/peds.87.4.519 · Cited by 283 · see citing works
148th Annual Meeting of the American Psychiatric Association
Dittmann, V., Krausz, M. R., Haasen, C., Mass, R., Wagner, H.-B., Peter, H., Freyberger, H. J., Wïttchen, H., Perkonigg, A., Krausz, M. R., et al. (2010) · European Addiction Research · doi:10.1159/000319611 · Cited by 259 · see citing works
Wender, P. H., Reimherr, F. W., Wood, D., & Ward, M. F. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.5.547 · Cited by 257 · see citing works
Methylphenidate Effects on Symptoms of Attention Deficit Disorder in Adults
Mattes, J. A. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790220049008 · Cited by 177 · see citing works
Genetics of adult attention-deficit/hyperactivity disorder
Faraone, S. V. (2004) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(03)00090-x · Cited by 166 · see citing works
Attention Deficit Disorders in Adults
Gualtieri, C. T., Ondrusek, M. G., & Finley, C. C. (1985) · Clinical Neuropharmacology · doi:10.1097/00002826-198512000-00005 · Cited by 109 · see citing works
Brain function and structure in adults with attention-deficit/hyperactivity disorder
Seidman, L. J., Valera, E. M., & Bush, G. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.01.002 · Cited by 106 · see citing works
Rapport, M. D., Jones, J. T., DuPaul, G. J., Kelly, K. L., Gardner, M. J., Tucker, S. B., & Shea, M. S. (1987) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp1604_6 · Cited by 91 · see citing works
Bouffard, R., Hechtman, L., Minde, K., & Iaboni-Kassab, F. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800806 · Cited by 81 · see citing works
Attention Deficit Disorder With and Without Hyperactivity
Hynd, G. W., Nieves, N., Connor, R. T., Stone, P. A., Town, P., Becker, M. G., Lahey, B. B., & Lorys, A. R. (1989) · Journal of Learning Disabilities · doi:10.1177/002221948902200910 · Cited by 68 · see citing works
Nonstimulant treatment of adult attention-deficit/hyperactivity disorder
Spencer, T. J., Biederman, J., & Wilens, T. E. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2003.12.001 · Cited by 65 · see citing works
Self-citationMethylphenidate and Dextroamphetamine Abuse in Substance‐Abusing Adolescents
Williams, R. J., Goodale, L. A., Shay‐Fiddler, M. A., Gloster, S. P., & Chang, S. Y. (2004) · American Journal on Addictions · doi:10.1080/10550490490483053 · Cited by 63 · see citing works
Stimulant treatment of adult attention-deficit/hyperactivity disorder
Spencer, T. J., Biederman, J., & Wilens, T. E. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2003.12.002 · Cited by 52 · see citing works
Self-citationAnnual Meeting of American Psychiatric Association
(1935) · Psychiatric Quarterly · doi:10.1007/bf01563828 · Cited by 29 · see citing works
Attention Deficit Disorder and Methylphenidate
Millichap, J. G. (1987) · Pediatric Neurology Briefs · doi:10.15844/pedneurbriefs-1-3-11 · Cited by 21 · see citing works
Adult attention-deficit/hyperactivity disorder
Spencer, T. J. (2004) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(04)00017-6 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kooij, S. J., Bejerot, S., Blackwell, A., Caci, H., Casas-Brugué, M., Carpentier, P. J., Edvinsson, D., Fayyad, J., Foeken, K., Fitzgerald, M., et al. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-67 · Cited by 928 · see citing works
“In the United States, more than ten different stimulant preparations have been developed for treatment of ADHD, the most recent being long acting formulations of oros-methylphenidate, mixed amphetamine salts, dexmethylphenidate and lis-dexamphetamine [265,287,288].”
Yen, J.-Y., Ko, C.-H., Yen, C.-F., Wu, H.-Y., & Yang, M.-J. (2007) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2007.02.002 · Cited by 817 · see citing works
Sallee, F. R., Mcgough, J., Wigal, T., Donahue, J., Lyne, A., & Biederman, J. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318191769e · Cited by 391 · see citing works
Self-citationFaraone, S. V., & Glatt, S. J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04902pur · Cited by 387 · see citing works
Banaschewski, T., Coghill, D., Santosh, P., Zuddas, A., Asherson, P., Buitelaar, J., Danckaerts, M., Döpfner, M., Faraone, S. V., Rothenberger, A., et al. (2006) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-006-0549-0 · Cited by 375 · see citing works
Wolff, Ä., Joshi, R. K., Ekström, J., Aframian, D. J., Pedersen, A. M. L., Proctor, G., Narayana, N., Villa, A., Sia, Y. W., Aliko, A., et al. (2016) · Drugs in R&D · doi:10.1007/s40268-016-0153-9 · Cited by 379 · see citing works
Associations of sleep disturbance with ADHD: implications for treatment
Hvolby, A. (2015) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0151-0 · Cited by 339 · see citing works
Psychiatric Comorbidity of Internet Addiction in College Students: An Interview Study
Ko, C., Yen, J., Chen, C., Chen, C.-C., & Yen, C. (2008) · CNS Spectrums · doi:10.1017/s1092852900016308 · Cited by 254 · see citing works
Levin, F. R., Evans, S. M., Brooks, D. J., & Garawi, F. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.07.004 · Cited by 220 · see citing works
Bush, G., Spencer, T. J., Holmes, J., Shin, L. M., Valera, E. M., Seidman, L. J., Makris, N., Surman, C., Aleardi, M., Mick, E., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.16 · Cited by 201 · see citing works
Self-citationCastells, X., Ramos-Quiroga, J. A., Rigau, D., Bosch, R., Nogueira, M., Vidal, X., & Casas, M. (2011) · CNS Drugs · doi:10.2165/11539440-000000000-00000 · Cited by 197 · see citing works
Literature Review: ADHD in Adults
Davidson, M. A. (2007) · Journal of Attention Disorders · doi:10.1177/1087054707310878 · Cited by 190 · see citing works
Medori, R., Ramos-Quiroga, J. A., Casas, M., Kooij, J. J. S., Niemelä, A., Trott, G.-E., Lee, E., & Buitelaar, J. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.008 · Cited by 186 · see citing works
Distinguishing comorbidity and successful management of adult ADHD
Kooij, J. J. S., Huss, M., Asherson, P., Akehurst, R., Beusterien, K., French, A., Sasané, R., & Hodgkins, P. (2012) · Journal of Attention Disorders · doi:10.1177/1087054711435361 · Cited by 172 · see citing works
Atomoxetine treatment of adults with ADHD and comorbid alcohol use disorders
Wilens, T. E., Adler, L. A., Weiss, M. D., Michelson, D., Ramsey, J. L., Moore, R. J., Renard, D., Brady, K. T., Trzepacz, P. T., Schuh, L. M., et al. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.02.009 · Cited by 171 · see citing works
SULLIVAN, M. A., & RUDNIK‐LEVIN, F. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05783.x · Cited by 172 · see citing works
Konstenius, M., Jayaram‐Lindström, N., Guterstam, J., Beck, O., Philips, B., & Franck, J. (2014) · Addiction · doi:10.1111/add.12369 · Cited by 188 · see citing works
Pliszka, S. R. (2007) · Neuropsychology Review · doi:10.1007/s11065-006-9017-3 · Cited by 158 · see citing works
Treatment of adults with attention-deficit/hyperactivity disorder
Hechtman, L. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s6985 · Cited by 157 · see citing works
on behalf of the study group, Rösler, M., Fischer, R., Ammer, R., Ose, C., & Retz, W. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0845-4 · Cited by 155 · see citing works
Attention deficit hyperactivity disorder in adults
Rösler, M., Casas, M., Konofal, É., & Buitelaar, J. K. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.483249 · Cited by 140 · see citing works
Adler, L., Spencer, T., Brown, T. E., Holdnack, J., Saylor, K. E., Schuh, K., Trzepacz, P., Williams, D., & Kelsey, D. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318192e4a0 · Cited by 150 · see citing works
Self-citationKoesters, M., Becker, T., Kilian, R., Fegert, J., & Weinmann, S. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108092338 · Cited by 142 · see citing works
Do prescription stimulants increase the risk of adverse cardiovascular events?: A systematic review
Westover, A. N., & Halm, E. A. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-41 · Cited by 141 · see citing works
Wigal, T., Brams, M., Gasior, M., Gao, J., Squires, L., Giblin, J., & 316 Study Group (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-34 · Cited by 136 · see citing works
“The common AEs in the current study, including decreased appetite, dry mouth, headache, and insomnia, are consistently seen in studies of long-acting stimulant medications administered to adults [12,18, 35 ,36].”
BackgroundMick, E. O., McManus, D. D., & Goldberg, R. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.011 · Cited by 134 · see citing works
Self-citationRösler, M., Retz, W., Fischer, R., Ose, C., Alm, B., Deckert, J., Philipsen, A., Herpertz, S., & Ammer, R. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003624197 · Cited by 131 · see citing works
McCarthy, S., Cranswick, N., Potts, L., Taylor, E., & Wong, I. C. K. (2009) · Drug Safety · doi:10.2165/11317630-000000000-00000 · Cited by 128 · see citing works
Martínez-Raga, J., Knecht, C., Szerman, N., & Martinez, M. I. (2012) · CNS Drugs · doi:10.1007/s40263-012-0019-9 · Cited by 128 · see citing works
Cardiometabolic effects of psychotropic medications
Abosi, O. J., Lopes, S., Schmitz, S. L., & Fiedorowicz, J. G. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0065 · Cited by 128 · see citing works
Winterstein, A. G., Gerhard, T., Shuster, J., Johnson, M., Zito, J. M., & Saidi, A. (2007) · Pediatrics · doi:10.1542/peds.2007-0675 · Cited by 119 · see citing works
An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults
Wilens, T. E., Morrison, N. R., & Prince, J. B. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.137 · Cited by 113 · see citing works
Vitiello, B. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.11.010 · Cited by 110 · see citing works
Peterson, K., McDonagh, M. S., & Fu, R. (2008) · Psychopharmacology · doi:10.1007/s00213-007-0996-4 · Cited by 135 · see citing works
Blood Pressure and Heart Rate Over 10 Years in the Multimodal Treatment Study of Children With ADHD
Vitiello, B., Elliott, G. R., Swanson, J. M., Arnold, L. E., Hechtman, L. T., Abikoff, H., Molina, B. S. G., Wells, K., Wigal, T. L., Jensen, P. S., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111705 · Cited by 106 · see citing works
Liang, E., Lim, S., Tam, W., Ho, C. S. H., Zhang, M. W. B., McIntyre, R., & Ho, R. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081789 · Cited by 95 · see citing works
Adler, L. A., Zimmerman, B., Starr, H. L., Silber, S., Palumbo, J., Orman, C., & Spencer, T. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181a390ce · Cited by 106 · see citing works
Self-citationNutrient supplementation approaches in the treatment of ADHD
Rucklidge, J. J., Johnstone, J. M., & Kaplan, B. J. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.7 · Cited by 97 · see citing works
Mick, E., Faraone, S. V., Spencer, T., Zhang, H. F., & Biederman, J. (2008) · Journal of Attention Disorders · doi:10.1177/1087054707308468 · Cited by 95 · see citing works
Self-citationWeisler, R., Young, J., Mattingly, G., Gao, J., Squires, L., Adler, L., & 304 Study Group (2009) · CNS Spectrums · doi:10.1017/s1092852900024056 · Cited by 94 · see citing works
Attention Deficit Hyperactivity Disorder Across the Lifespan: The Child, Adolescent, and Adult
Greydanus, D. E., Pratt, H. D., & Patel, D. R. (2007) · Disease-a-Month · doi:10.1016/j.disamonth.2007.01.001 · Cited by 94 · see citing works
Winhusen, T. M., Somoza, E. C., Brigham, G. S., Liu, D. S., Green, C. A., Covey, L. S., Croghan, I. T., Adler, L. A., Weiss, R. D., Leimberger, J. D., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05089gry · Cited by 90 · see citing works
Elliott, J., Johnston, A., Husereau, D., Kelly, S., Eagles, C., Charach, A., Hsieh, S., Bai, Z., Hossain, A., Skidmore, B., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240584 · Cited by 93 · see citing works
Organizational-skills interventions in the treatment of ADHD
Langberg, J. M., Epstein, J. N., & Graham, A. J. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.10.1549 · Cited by 81 · see citing works
Safety of therapeutic methylphenidate in adults: a systematic review of the evidence
Godfrey, J. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108089809 · Cited by 77 · see citing works
Cervelló, X. C., Casas, M., Vidal, X., Bosch, R., Roncero, C., Ramos‐Quiroga, J. A., & Capellà, D. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01943.x · Cited by 74 · see citing works
Winterstein, A. G., Gerhard, T., Kubilis, P. S., Saidi, A. S., Linden, S., Crystal, S., Zito, J., Shuster, J. J., & Olfson, M. (2012) · BMJ · doi:10.1136/bmj.e4627 · Cited by 69 · see citing works
Drug-related hypertension and resistance to antihypertensive treatment
Rossi, G. P., Seccia, T. M., Maniero, C., & Pessina, A. C. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834c465d · Cited by 68 · see citing works
The Complexity of ADHD: Diagnosis and Treatment of the Adult Patient With Comorbidities
Newcorn, J. H., Weiss, M., & Stein, M. A. (2007) · CNS Spectrums · doi:10.1017/s1092852900026158 · Cited by 66 · see citing works
Biederman, J., Mick, E., Fried, R., Wilner, N., Spencer, T. J., & Faraone, S. V. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.11.005 · Cited by 67 · see citing works
Self-citationPerspectives on the assessment and treatment of adult ADHD in hypersexual men
Reid, R. C., Davtian, M., Lenartowicz, A., Torrevillas, R. M., & FONG, T. W. (2013) · Neuropsychiatry · doi:10.2217/npy.13.31 · Cited by 67 · see citing works
ADHD in old age: a review of the literature and proposal for assessment and treatment
Kooij, J. J. S., Michielsen, M., Kruithof, H., & Bijlenga, D. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1204914 · Cited by 60 · see citing works
Biederman, J., Fried, R. S., DiSalvo, M., Storch, B., Pulli, A., Woodworth, K. Y., Biederman, I., Faraone, S. V., & Perlis, R. H. (2019) · Psychiatric Services · doi:10.1176/appi.ps.201800515 · Cited by 64 · see citing works
Self-citationRetz, W., Rösler, M., Ose, C., Scherag, A., Alm, B., Philipsen, A., Fischer, R., Ammer, R., & The Study Group (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.540257 · Cited by 79 · see citing works
Santosh, P. J., Sattar, S., & Canagaratnam, M. (2011) · CNS Drugs · doi:10.2165/11593070-000000000-00000 · Cited by 62 · see citing works
Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults
Epstein, T., Patsopoulos, N. A., & Weiser, M. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005041.pub3 · Cited by 62 · see citing works
RetractedADHD in Children, Adolescents, and Adults
Katragadda, S., & Schubiner, H. (2007) · Primary Care: Clinics in Office Practice · doi:10.1016/j.pop.2007.04.012 · Cited by 61 · see citing works
Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.
Epstein, T., Patsopoulos, N., & Weiser, M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005041.pub2 · Cited by 87 · see citing works
RetractedBiederman, J., Fried, R., Hammerness, P., Surman, C., Mehler, B., Petty, C. R., Faraone, S. V., Miller, C., Bourgeois, M., Meller, B., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.007 · Cited by 60 · see citing works
Self-citationBiederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Kotarski, M., & Spencer, T. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181ee84a7 · Cited by 76 · see citing works
Self-citationSasaki, T. G., Hashimoto, K., Oda, Y., Ishima, T., Kurata, T., Takahashi, J., Kamata, Y., Kimura, H., Niitsu, T., Komatsu, H., et al. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.029 · Cited by 58 · see citing works
Aortic dissection in young adults who abuse amphetamines
Westover, A. N., & Nakonezny, P. A. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.05.021 · Cited by 59 · see citing works
Methylphenidate use in pregnancy and lactation: a systematic review of evidence
Bolea-Alamanac, B. M., Green, A. C., Verma, G., Maxwell, P., & Davies, S. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12138 · Cited by 54 · see citing works
Geissler, J. M., & Lesch, K. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.136 · Cited by 55 · see citing works
Ramos-Quiroga, J. A., Bosch, R., Castells, X., Valero, S., Nogueira, M., Gómez, N., Yelmo, S., Ferrer, M., Martínez, Y., & Casas, M. (2008) · CNS Drugs · doi:10.2165/00023210-200822070-00005 · Cited by 54 · see citing works
Rucklidge, J. J., Taylor, M. R., & Whitehead, K. (2010) · Journal of Attention Disorders · doi:10.1177/1087054709356173 · Cited by 54 · see citing works
Mick, E. O., Biederman, J., Spencer, T. J., Faraone, S. V., & Sklar, P. B. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30376 · Cited by 51 · see citing works
Self-citationAttention-Deficit/Hyperactivity Disorder in Adults: Evidence-Based Recommendations for Management
Rostain, A. L. (2008) · Postgraduate Medicine · doi:10.3810/pgm.2008.09.1905 · Cited by 50 · see citing works
Pharmacotherapy of ADHD in Adults
Wilens, T. E. (2008) · CNS Spectrums · doi:10.1017/s1092852900002960 · Cited by 50 · see citing works
Treatment of adult ADHD: Is current knowledge useful to clinicians?
Torgersen, T. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s1223 · Cited by 49 · see citing works
Shang, C., Yan, C., Lin, H., Tseng, W. I., Castellanos, F. X., & Gau, S. S. (2016) · Psychological Medicine · doi:10.1017/s0033291716001938 · Cited by 48 · see citing works
Do stimulants improve functioning in adults with ADHD?
Surman, C. B. H., Hammerness, P. G., Pion, K., & Faraone, S. V. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.02.010 · Cited by 47 · see citing works
Self-citationLong-Term Safety of OROS Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder
Adler, L. A., Orman, C., Starr, H. L., Silber, S., Palumbo, J., Cooper, K., Berwaerts, J., & Harrison, D. D. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318203ea0a · Cited by 47 · see citing works
Sanefuji, M., Craig, M., Parlatini, V., Mehta, M. A., Murphy, D., Catani, M., Cerliani, L., & de Schotten, M. T. (2016) · Cortex · doi:10.1016/j.cortex.2016.06.005 · Cited by 48 · see citing works
Goodman, D. W., & Thase, M. E. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.09.2049 · Cited by 46 · see citing works
Drug-Induced Hypertension: Focus on Mechanisms and Management
Lovell, A. R., & Ernst, M. E. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0736-z · Cited by 47 · see citing works
López, F. A., & Leroux, J. R. (2013) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-013-0106-x · Cited by 43 · see citing works
Atomoxetine and Cerebrovascular Outcomes in Adults
Holick, C. N., Turnbull, B., Jones, M., Chaudhry, S., Bangs, M. E., & Seeger, J. D. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181b2b828 · Cited by 42 · see citing works
Fallu, A., Richard, C., Prinzo, R., & Binder, C. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x154132 · Cited by 42 · see citing works
Methylphenidate Transdermal System in Adult ADHD and Impact on Emotional and Oppositional Symptoms
Marchant, B. K., Reimherr, F. W., Robison, R. J., Olsen, J. L., & Kondo, D. G. (2011) · Journal of Attention Disorders · doi:10.1177/1087054710365986 · Cited by 51 · see citing works
Bush, G., Holmes, J., Shin, L. M., Surman, C. B. H., Makris, N., Mick, E. O., Seidman, L. J., & Biederman, J. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.09.004 · Cited by 41 · see citing works
Self-citationStuhec, M., Lukić, P., & Locatelli, I. (2019) · Annals of Pharmacotherapy · doi:10.1177/1060028018795703 · Cited by 46 · see citing works
Chou, T.-L., Chia, S., Shang, C.-Y., & Gau, S. S.-F. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.024 · Cited by 44 · see citing works
Katzman, M. A., & Sternat, T. (2014) · CNS Drugs · doi:10.1007/s40263-014-0175-1 · Cited by 40 · see citing works
Methylphenidate for the Treatment of Parkinson Disease and Other Neurological Disorders
Auriel, E., Hausdorff, J. M., & Giladi, N. (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e318170576c · Cited by 40 · see citing works
Moncrieff, J., & Timimi, S. B. (2013) · Anthropology and Medicine · doi:10.1080/13648470.2012.747591 · Cited by 39 · see citing works
Non-medical use of methylphenidate: a review
Freese, L., Signor, L., Machado, C. A., Ferigolo, M., & Barros, H. M. T. (2012) · Trends in Psychiatry and Psychotherapy · doi:10.1590/s2237-60892012000200010 · Cited by 38 · see citing works
Predictors of treatment outcome in adults with ADHD treated with OROS® methylphenidate.
Buitelaar, J., Kooij, J. J. S., Ramos-Quiroga, J., Dejonckheere, J., Casas, M., van Oene, J. V., Schäuble, B., & Trott, G. (2011) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.016 · Cited by 43 · see citing works
Imaging dopamine neurotransmission in live human brain
Badgaiyan, R. D. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00007-6 · Cited by 38 · see citing works
Biederman, J., Mick, E. O., Surman, C. B. H., Doyle, R., Hammerness, P. G., Michel, E., Martin, J., & Spencer, T. J. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-49 · Cited by 37 · see citing works
Self-citationPharmacological treatment of adult ADHD in Europe
Retz, W., Retz‐Junginger, P., Thome, J., & Rösler, M. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.603229 · Cited by 36 · see citing works
Methylphenidate off-label use and safety
Trenque, T. C., Herlem, E., Taam, M. A., & Dramé, M. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-286 · Cited by 35 · see citing works
Toward Quality Care in ADHD: Defining the Goals of Treatment
Rostain, A., Jensen, P. S., Connor, D. F., Miesle, L. M., & Faraone, S. V. (2015) · Journal of Attention Disorders · doi:10.1177/1087054712473835 · Cited by 33 · see citing works
Corbisiero, S., Bitto, H., Newark, P. E., Mörstedt, B., Elsässer, M., Buchli-Kammermann, J., Künne, S., Nyberg, E., Fallahpour, M. H., & Stieglitz, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00571 · Cited by 33 · see citing works
Is Methylphenidate Beneficial and Safe in Pharmacological Cognitive Enhancement?
Kapur, A. (2020) · CNS Drugs · doi:10.1007/s40263-020-00758-w · Cited by 34 · see citing works
Osmotic, controlled-release methylphenidate for the treatment of ADHD
Coghill, D., & Seth, S. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.15.2119 · Cited by 33 · see citing works
Lensing, M. B., Zeiner, P., Sandvik, L., & Opjordsmoen, S. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07714 · Cited by 32 · see citing works
Mattingly, G. W., Weisler, R. H., Young, J. L., Adeyi, B. A., Dirks, B., Babcock, T., Lasser, R. A., Scheckner, B., & Goodman, D. W. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-39 · Cited by 32 · see citing works
Idrees, I., Bellato, A., Cortese, S., & Groom, M. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104968 · Cited by 34 · see citing works
Castells, X., Cunill, R., & Capellà, D. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1390-7 · Cited by 41 · see citing works
- Authors
- Biederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Harpold, T., Dunkel, S., Dougherty, M., Aleardi, M., & Spencer, T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Biederman, Joseph
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 59
- Issue
- 9
- Pages
- 829-835
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2164676183
- Cited by
- 267
- References
- 29
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 2 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 14 · 2015: 7 · 2014: 18 · 2013: 16 · 2012: 20
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- OROS methylphenidate, attention deficit hyperactivity disorder, adult ADHD, sustained-release formulation, inattention, hyperactivity/impulsivity, blood pressure, heart rate, drug safety and efficacy, dose titration
- MeSH terms
- Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Cardiovascular System, Dose-Response Relationship, Drug, Double-Blind Method, Drug Evaluation, Female, Follow-Up Studies, Humans, Male, Methylphenidate, Middle Aged, Psychiatric Status Rating Scales, Chi-Square Distribution, Treatment Outcome
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