Cited by 128Congenital Heart Disease StudiesFetal and Pediatric Neurological DisordersCongenital heart defects research

Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes

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von Rhein, Michael, Buchmann, Andreas, Hagmann, Cornelia, Dave, Hitendu, Bernet, Vera, Scheer, Ianina, Knirsch, Walter, Latal, Beatrice +14 more·2015·The Journal of Pediatrics

Abstract

Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).Conclusions Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.

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Crossref · 10.1016/j.jpeds.2015.07.006

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Authors
von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., Dave, H., Prêtre, R., Hagmann, C., Knirsch, W., Kretschmar, O., Kellenberger, C., Scheer, I., Latal, B., Liamlahi, R., von Rhein, M., Plecko, B. R., & Sennhauser, F. H.
Affiliations
University Hospital Zurich (CH)
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2015-12
Volume
167
Issue
6
Pages
1259-1263.e1
ISSN
0022-3476 (ISSN-L)
OpenAlex
W1601921345
Cited by
128
References
29
Citations by year
2026: 10 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 1
FWCI
7.59
Type
journal article
Language
en
Open access
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Else Kröner-Fresenius-Stiftung
  • Schweizerische Herzstiftung
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PMPDP3_129104)
Topics
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
congenital heart disease, brain volumetry, fetal brain development, open heart surgery
MeSH terms
Brain, Developmental Disabilities, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Prospective Studies, Switzerland, Cohort Studies

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