Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
Open accessAbstract
Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).Conclusions Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
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In the postnatal period before surgery, cerebellar volume is reduced by 20% in neonates with single ventricle pathology and transposition of the great arteries.
“However, in the postnatal period (before surgery), a reduction of 20 per cent in cerebellar volume in neonates with SVP and TGA (n=19) has been observed.34”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In neonatal studies, white matter and cortical gray matter are comparably reduced in transposition of the great arteries and single ventricle pathology.
“In neonatal studies, white matter and CGM are comparably reduced in TGA and SVP.34,39”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
The basal ganglia and thalami are smaller in single ventricle pathology and transposition of the great arteries than in healthy controls, in both fetal and neonatal periods.
“In addition, the basal ganglia and thalami are smaller in SVP and TGA when compared with healthy controls, in both the fetal 38 and neonatal 34 period.”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
Cites
Abnormal brain development in newborns with congenital heart disease
Miller, S. P., McQuillen, P. S., Hamrick, S., Xu, D., Glidden, D. V., Charlton, N., Karl, T., Azakie, A., Ferriero, D. M., Barkovich, A. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067393 · Cited by 860 · see citing works
Bellinger, D. C., Wypij, D., duPlessis, A. J., Rappaport, L. A., Jonas, R. A., Wernovsky, G., & Newburger, J. W. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00711-6 · Cited by 681 · see citing works
Limperopoulos, C., Tworetzky, W., McElhinney, D. B., Newburger, J. W., Brown, D. W., Robertson, R. L., Guizard, N., McGrath, E., Geva, J., Annese, D., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.865568 · Cited by 663 · see citing works
Brain maturation is delayed in infants with complex congenital heart defects
Licht, D. J., Shera, D. M., Clancy, R. R., Wernovsky, G., Montenegro, L. M., Nicolson, S. C., Zimmerman, R. A., Spray, T. L., Gaynor, J. W., & Vossough, A. (2009) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.10.025 · Cited by 629 · see citing works
An MRI Study of Neurological Injury Before and After Congenital Heart Surgery
Mahle, W. T., Tavani, F., Zimmerman, R. A., Nicolson, S. C., Galli, K. K., Gaynor, J. W., Clancy, R. R., Montenegro, L. M., Spray, T. L., Chiavacci, R. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000032908.33237.b1 · Cited by 541 · see citing works
Sun, L., Macgowan, C. K., Sled, J. G., Yoo, S.-J., Manlhiot, C., Porayette, P., Grosse-Wortmann, L., Jaeggi, E., McCrindle, B. W., Kingdom, J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013051 · Cited by 533 · see citing works
Bellinger, D. C., Wypij, D., Rivkin, M. J., DeMaso, D. R., Robertson, R. L., Dunbar-Masterson, C., Rappaport, L. A., Wernovsky, G., Jonas, R. A., & Newburger, J. W. (2011) · Circulation · doi:10.1161/circulationaha.111.026963 · Cited by 476 · see citing works
Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects
McQuillen, P. S., Barkovich, A. J., Hamrick, S. E. G., Perez, M., Ward, P., Glidden, D. V., Azakie, A., Karl, T., & Miller, S. P. (2007) · Stroke · doi:10.1161/01.str.0000247941.41234.90 · Cited by 379 · see citing works
Delayed cortical development in fetuses with complex congenital heart disease
Clouchoux, C., du Plessis, A. J., Bouyssi-Kobar, M., Tworetzky, W., McElhinney, D. B., Brown, D. W., Gholipour, A., Kudelski, D., Warfield, S. K., McCarter, R. J., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs281 · Cited by 309 · see citing works
Beca, J., Gunn, J. K., Coleman, L., Hope, A., Reed, P. W., Hunt, R. W., Finucane, K., Brizard, C., Dance, B., & Shekerdemian, L. S. (2013) · Circulation · doi:10.1161/circulationaha.112.001089 · Cited by 301 · see citing works
Petit, C. J., Rome, J. J., Wernovsky, G., Mason, S. E., Shera, D. M., Nicolson, S. C., Montenegro, L. M., Tabbutt, S., Zimmerman, R. A., & Licht, D. J. (2009) · Circulation · doi:10.1161/circulationaha.107.760819 · Cited by 282 · see citing works
Limperopoulos, C., Majnemer, A., Shevell, M. I., Rosenblatt, B., Rohlicek, C., & Tchervenkov, C. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.109152 · Cited by 274 · see citing works
A Systematic Review of Motor and Cognitive Outcomes After Early Surgery for Congenital Heart Disease
Snookes, S. H., Gunn, J. K., Eldridge, B. J., Donath, S. M., Hunt, R. W., Galea, M. P., & Shekerdemian, L. (2010) · Pediatrics · doi:10.1542/peds.2009-1959 · Cited by 260 · see citing works
Brain injury and development in newborns with critical congenital heart disease
Dimitropoulos, A., McQuillen, P. S., Sethi, V., Moosa, A., Chau, V., Xu, D., Brant, R., Azakie, A., Campbell, A., Barkovich, A. J., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31829bfdcf · Cited by 236 · see citing works
Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease
von Rhein, M., Buchmann, A., Hagmann, C., Huber, R., Klaver, P., Knirsch, W., & Latal, B. (2014) · Brain · doi:10.1093/brain/awt322 · Cited by 187 · see citing works
Self-citationHövels-Gürich, H. H., Konrad, K., Skorzenski, D., Nacken, C., Minkenberg, R., Messmer, B. J., & Seghaye, M.-C. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.09.010 · Cited by 157 · see citing works
Developmental and Functional Outcomes at School Entry in Children with Congenital Heart Defects
Majnemer, A., Limperopoulos, C., Shevell, M. I., Rohlicek, C. V., Rosenblatt, B., & Tchervenkov, C. I. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.12.019 · Cited by 154 · see citing works
Prenatal Head Growth and White Matter Injury in Hypoplastic Left Heart Syndrome
Hinton, R. B., Andelfinger, G., Sekar, P., Hinton, A. C., Gendron, R. L., Michelfelder, E. C., Robitaille, Y., & Benson, D. W. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e3181827bf4 · Cited by 118 · see citing works
Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects
Owen, M., Shevell, M., Donofrio, M., Majnemer, A., McCarter, R., Vezina, G., Bouyssi-Kobar, M., Evangelou, I., Freeman, D., Weisenfeld, N., et al. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.11.033 · Cited by 115 · see citing works
PIPARI Study Group, Lind, A., Parkkola, R. K., Lehtonen, L., Munck, P., Maunu, J., Lapinleimu, H., & Haataja, L. M. (2011) · Pediatric Radiology · doi:10.1007/s00247-011-2071-x · Cited by 110 · see citing works
Impact of congenital heart disease on fetal brain development and injury
Donofrio, M. T., duPlessis, A. J., & Limperopoulos, C. (2011) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32834aa583 · Cited by 104 · see citing works
Ortinau, C., Beca, J., Lambeth, J., Ferdman, B., Alexopoulos, D., Shimony, J. S., Wallendorf, M., Neil, J., & Inder, T. (2012) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2011.10.039 · Cited by 94 · see citing works
Encephalopathy of Congenital Heart Disease– Destructive and Developmental Effects Intertwined
Volpe, J. J. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.002 · Cited by 90 · see citing works
Owen, M., Shevell, M. I., Majnemer, A., & Limperopoulos, C. (2011) · Journal of Child Neurology · doi:10.1177/0883073811402073 · Cited by 73 · see citing works
Bertholdt, S., Latal, B., Liamlahi, R., Pretre, R., Scheer, I., Goetti, R., Dave, H., Bernet, V., Schmitz, A., von Rhein, M., et al. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezt422 · Cited by 64 · see citing works
Self-citationStructural Brain Lesions in Adolescents with Congenital Heart Disease
von Rhein, M., Scheer, I., Loenneker, T., Huber, R., Knirsch, W., & Latal, B. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.11.040 · Cited by 61 · see citing works
Self-citationDiffusion-Weighted Imaging in Fetuses with Severe Congenital Heart Defects
Berman, J., Hamrick, S. E. G., McQuillen, P. S., Studholme, C., Xu, D., Henry, R. G., Hornberger, L. K., & Glenn, O. A. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1975 · Cited by 36 · see citing works
Congenital Heart Disease Affects Cerebral Size but Not Brain Growth
Ortinau, C. M., Inder, T. E., Lambeth, J., Wallendorf, M., Finucane, K. A., & Beca, J. (2012) · Pediatric Cardiology · doi:10.1007/s00246-012-0269-9 · Cited by 34 · see citing works
Makki, M., Scheer, I., Hagmann, C., Liamlahi, R., Knirsch, W., Dave, H., Bernet, V., Batinic, K., & Latal, B. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3256 · Cited by 10 · see citing works
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Brain Injury and Neurodevelopmental Outcome in Congenital Heart Disease: A Systematic Review
Mebius, M. J., Kooi, E. M. W., Bilardo, C. M., & Bos, A. F. (2017) · PEDIATRICS · doi:10.1542/peds.2016-4055 · Cited by 166 · see citing works
The neonatal brain in critical congenital heart disease: Insights and future directions
Peyvandi, S., Latal, B., Miller, S. P., & McQuillen, P. S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.045 · Cited by 165 · see citing works
Self-citationCognitive and Executive Function in Congenital Heart Disease: A Meta-analysis
Feldmann, M., Bataillard, C., Ehrler, M., Ullrich, C., Knirsch, W., Gosteli, M., Held, U., & Latal, B. (2021) · PEDIATRICS · doi:10.1542/peds.2021-050875 · Cited by 144 · see citing works
Self-citationHuisenga, D. C., Gemert, S. L. B., Bergen, A. V., Sweeney, J. K., & Hadders‐Algra, M. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14512 · Cited by 128 · see citing works
Claessens, N. H. P., Algra, S. O., Ouwehand, T. L., Jansen, N. J. G., Schappin, R., Haas, F., Eijsermans, M. J. C., de Vries, L. S., Benders, M. J. N. L., & CHD Lifespan Study Group Utrecht (2018) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13747 · Cited by 123 · see citing works
Ware, J., Butcher, J. L., Latal, B., Sadhwani, A., Rollins, C. K., Brosig, C. L., Butler, S., Eiler-Sims, P. B., Shade, C. U., & Wernovsky, G. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003534 · Cited by 126 · see citing works
Self-citationIlardi, D. L., Sanz, J. H., Cassidy, A. R., Sananes, R., Rollins, C. K., Shade, C. U., Carroll, G., & Bellinger, D. C. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003546 · Cited by 103 · see citing works
Cerebral oxygen delivery is reduced in newborns with congenital heart disease
Lim, J. M., Kingdom, T., Saini, B., Chau, V., Post, M., Blaser, S., Macgowan, C., Miller, S. P., & Seed, M. (2016) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.05.027 · Cited by 86 · see citing works
Peyvandi, S., Kim, H., Lau, J. C. Y., Barkovich, A. J., Campbell, A., Miller, S. P., Xu, D., & McQuillen, P. S. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.08.019 · Cited by 84 · see citing works
Guo, T., Chau, V., Peyvandi, S., Latal, B., McQuillen, P. S., Knirsch, W., Synnes, A. R., Feldmann, M., Naef, N., Chakravarty, M. M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.06.004 · Cited by 85 · see citing works
Self-citationNeurodevelopmental outcomes of children with congenital heart disease: A review
Howell, H. B., Zaccario, M. L., Kazmi, S. H., Desai, P. V., Sklamberg, F. E., & Mally, P. (2019) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2019.100685 · Cited by 84 · see citing works
Delayed cortical gray matter development in neonates with severe congenital heart disease
; on behalf of the Research Group Heart and Brain, Claessens, N. H. P., Moeskops, P., Buchmann, A., Latal, B., Knirsch, W., Scheer, I., Išgum, I., de Vries, L. S., Benders, M. J. N. L., et al. (2016) · Pediatric Research · doi:10.1038/pr.2016.145 · Cited by 66 · see citing works
Self-citationWhite Matter Volume Predicts Language Development in Congenital Heart Disease
Rollins, C. K., Asaro, L. A., Akhondi-Asl, A., Kussman, B. D., Rivkin, M. J., Bellinger, D. C., Warfield, S. K., Wypij, D., Newburger, J. W., & Soul, J. S. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.09.070 · Cited by 70 · see citing works
Prenatal to postnatal trajectory of brain growth in complex congenital heart disease
Ortinau, C. M., Mangin-Heimos, K., Moen, J., Alexopoulos, D. K., Inder, T. E., Gholipour, A., Shimony, J. S., Eghtesady, P., Schlaggar, B. L., & Smyser, C. D. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.09.029 · Cited by 69 · see citing works
Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes
León, R. L., Mir, I. N., Herrera, C. L., Sharma, K., Spong, C. Y., Twickler, D. M., & Chalak, L. F. (2021) · Pediatric Research · doi:10.1038/s41390-021-01521-7 · Cited by 68 · see citing works
Fetal Brain Development in Congenital Heart Disease
Peyvandi, S., & Rollins, C. K. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.09.020 · Cited by 68 · see citing works
Meuwly, E., Feldmann, M., Knirsch, W., von Rhein, M., Payette, K., Dave, H. H., Tuura, R., Kottke, R., Hagmann, C. F., Latal, B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47328-9 · Cited by 65 · see citing works
Self-citationNeurodevelopmental outcome of children with congenital heart disease
Liamlahi, R., & Latal, B. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64029-1.00016-3 · Cited by 67 · see citing works
Self-citationOptimizing Neurodevelopmental Outcomes in Neonates With Congenital Heart Disease
Ortinau, C. M., Smyser, C. D., Arthur, L., Gordon, E. E., Heydarian, H. C., Wolovits, J. S., Nedrelow, J. H., Marino, B. S., & Levy, V. Y. (2022) · PEDIATRICS · doi:10.1542/peds.2022-056415l · Cited by 64 · see citing works
Factors Influencing Neurodevelopment after Cardiac Surgery during Infancy
Hövels-Gürich, H. H. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00137 · Cited by 64 · see citing works
; on behalf of the Research Group Heart and Brain., Latal, B., Patel, P., Liamlahi, R., Knirsch, W., O’Gorman Tuura, R., & von Rhein, M. (2016) · Pediatric Research · doi:10.1038/pr.2016.122 · Cited by 62 · see citing works
Self-citationRoberts, S. D., Kazazian, V., Ford, M. K., Marini, D., Miller, S. P., Chau, V., Seed, M., Ly, L. G., Williams, T. S., & Sananes, R. (2021) · The Clinical Neuropsychologist · doi:10.1080/13854046.2021.1896037 · Cited by 63 · see citing works
Verrall, C. E., Yang, J. Y., Chen, J., Schembri, A. J., d’Udekem, Y., Zannino, D., Kasparian, N. A., du Plessis, K., Grieve, S. M., Welton, T., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.048202 · Cited by 60 · see citing works
Claessens, N. H. P., Kelly, C. J., Counsell, S. J., & Benders, M. J. N. L. (2017) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13461 · Cited by 59 · see citing works
Claessens, N. H. P., Khalili, N., Išgum, I., ter Heide, H., Steenhuis, T. J., Turk, E., Jansen, N. J. G., de Vries, L. S., Breur, J. M. P. J., de Heus, R., et al. (2019) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6021 · Cited by 48 · see citing works
Cortical Dysmaturation in Congenital Heart Disease
Leonetti, C., Back, S. A., Gallo, V., & Ishibashi, N. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.003 · Cited by 48 · see citing works
Ceschin, R. C., Zahner, A., Reynolds, W., Gaesser, J. M., Zuccoli, G., Lo, C. W. Y., Gopalakrishnan, V., & Panigrahy, A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.049 · Cited by 43 · see citing works
Delayed maturation of the structural brain connectome in neonates with congenital heart disease
Feldmann, M., Guo, T., Miller, S. P., Knirsch, W., Kottke, R., Hagmann, C. F., Latal, B., & András, J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa209 · Cited by 44 · see citing works
Self-citationRollins, C. K., Newburger, J. W., & Roberts, A. E. (2017) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000530 · Cited by 42 · see citing works
Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease
Barkhuizen, M., Abella, R. F., Vles, J. S. H., Zimmermann, L. J. I., Gazzolo, D., & Gavilanes, A. W. D. (2020) · Pediatric Cardiology · doi:10.1007/s00246-020-02440-w · Cited by 42 · see citing works
Individualized brain development and cognitive outcome in infants with congenital heart disease
Bonthrone, A. F., Dimitrova, R., Chew, A. T. M., Kelly, C. J., Cordero‐Grande, L., Carney, O., Egloff, A. M., Hughes, E., Vecchiato, K., Simpson, J. M., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab046 · Cited by 42 · see citing works
Pironkova, R. P., Giamelli, J., Seiden, H., Parnell, V. A., Gruber, D., Sison, C. P., Kowal, C., & Ojamaa, K. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4493 · Cited by 40 · see citing works
Pike, N. A., Roy, B., Gupta, R., Singh, S., Woo, M. A., Halnon, N. J., Lewis, A. B., & Kumar, R. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24215 · Cited by 41 · see citing works
Brain volumes in adults with congenital heart disease correlate with executive function abilities
Naef, N., Schlosser, L., Brugger, P., Greutmann, M., Oxenius, A., Wehrle, F. M., Kottke, R., Latal, B., & Tuura, R. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00424-1 · Cited by 37 · see citing works
Self-citationStegeman, R., Sprong, M. C. A., Breur, J. M. P. J., Groenendaal, F., de Vries, L. S., Haas, F., van der Net, J. J., Jansen, N. J. G., Benders, M. J. N. L., Claessens, N. H. P., et al. (2021) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15024 · Cited by 38 · see citing works
Cerebral Blood Flow Monitoring in High-Risk Fetal and Neonatal Populations
León, R. L., Ortigoza, E. B., Ali, N., Angelis, D., Wolovits, J. S., & Chalak, L. F. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2021.748345 · Cited by 37 · see citing works
Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease
Cromb, D., Uus, A. U., van Poppel, M. P. M., Steinweg, J. K., Bonthrone, A. F., Maggioni, A., Cawley, P., Egloff, A. M., Kyriakopolous, V., Matthew, J., et al. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29078 · Cited by 37 · see citing works
Schmithorst, V. J., Votava‐Smith, J. K., Tran, N., Kim, R., Lee, V., Ceschin, R. C., Lai, H., Johnson, J. A., Sánchez-de-Toledo, J., Blüml, S., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24308 · Cited by 34 · see citing works
Fetal and neonatal neuroimaging
Counsell, S. J., Arichi, T., Arulkumaran, S., & Rutherford, M. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64029-1.00004-7 · Cited by 33 · see citing works
Ng, I. H. X., Bonthrone, A. F., Kelly, C. J., Cordero‐Grande, L., Hughes, E., Price, A. N., Hutter, J. M., Victor, S., Schuh, A., Rueckert, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72009-3 · Cited by 34 · see citing works
Szwast, A. L., Putt, M. E., Gaynor, J. W., Licht, D. J., & Rychik, J. R. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18919 · Cited by 30 · see citing works
Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth
Rajagopalan, V., Votava‐Smith, J. K., Zhuang, X., Brian, J., Marshall, L., Panigrahy, A., & Paquette, L. B. (2018) · Prenatal Diagnosis · doi:10.1002/pd.5374 · Cited by 30 · see citing works
Congenital Heart Defects and Measures of Prenatal Brain Growth: A Systematic Review
Hansen, T., Henriksen, T. B., Bach, C. C., & Matthiesen, N. B. (2017) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2017.03.014 · Cited by 29 · see citing works
MRI studies of brain size and growth in individuals with congenital heart disease
Bonthrone, A. F., Kelly, C. J., Ng, I. H. X., & Counsell, S. J. (2021) · Translational Pediatrics · doi:10.21037/tp-20-282 · Cited by 24 · see citing works
Badaly, D., Beers, S. R., Ceschin, R. C., Lee, V., Sulaiman, S., Zahner, A., Wallace, J., Berdaa-Sahel, A., Burns, C., Lo, C. W. Y., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.827780 · Cited by 27 · see citing works
Watson, C. G., Stopp, C. D., Wypij, D., Newburger, J. W., & Rivkin, M. J. (2017) · Pediatric Research · doi:10.1038/pr.2017.30 · Cited by 27 · see citing works
Gertsvolf, N., Votava‐Smith, J. K., Ceschin, R. C., del Castillo, S., Lee, V., Lai, H., Blüml, S., Paquette, L. B., & Panigrahy, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32288-3 · Cited by 26 · see citing works
Left temporal plane growth predicts language development in newborns with congenital heart disease
András, J., Meuwly, E., Feldmann, M., von Rhein, M., Kottke, R., Tuura, R., Latal, B., & Knirsch, W. (2019) · Brain · doi:10.1093/brain/awz067 · Cited by 25 · see citing works
Self-citationBhroin, M. N., Seada, S. A., Bonthrone, A. F., Kelly, C. J., Christiaens, D., Schuh, A., Pietsch, M., Hutter, J. M., Tournier, J., Cordero‐Grande, L., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102423 · Cited by 22 · see citing works
Campbell, M. J., Ziviani, J. M., Stocker, C. F., Khan, A., & Sakzewski, L. (2018) · Cardiology in the Young · doi:10.1017/s1047951118001622 · Cited by 21 · see citing works
Rudisill, S. S., Wang, J. T., Jaimes, C. E., Mongerson, C. R., Hansen, A. R., Jennings, R. W., & Bajic, D. (2019) · Brain Sciences · doi:10.3390/brainsci9120383 · Cited by 21 · see citing works
Selvanathan, T., Smith, J., Miller, S. P., & Field, T. S. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.02.009 · Cited by 21 · see citing works
Infants with congenital heart defects have reduced brain volumes
Skotting, M. B., Eskildsen, S. F., Ovesen, A. S. L., Fonov, V., Ringgaard, S., Hjortdal, V. E., & Lauridsen, M. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-83690-3 · Cited by 21 · see citing works
Dovjak, G. O., Hausmaninger, G., Zalewski, T., Schmidbauer, V. U., Weber, M., Worda, C., Mlczoch, E., Berger‐Kulemann, V., Prayer, D., Kasprian, G. J., et al. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.03.030 · Cited by 19 · see citing works
Cromb, D., Bonthrone, A. F., Maggioni, A., Cawley, P., Dimitrova, R., Kelly, C. J., Cordero‐Grande, L., Carney, O., Egloff, A. M., Hughes, E., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.028565 · Cited by 19 · see citing works
Fetal somatic growth trajectory differs by type of congenital heart disease
Puri, K., Warshak, C. R., Habli, M. A., Yuan, A., Sahay, R. D., King, E. C., Divanovic, A. A., & Cnota, J. F. (2017) · Pediatric Research · doi:10.1038/pr.2017.275 · Cited by 19 · see citing works
Growth and Intellectual Abilities of Six-Year-Old Children with Congenital Heart Disease
Heye, K., Rousson, V., Knirsch, W., Beck, I., Liamlahi, R., Bernet, V., Dave, H. H., & Latal, B. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.08.060 · Cited by 18 · see citing works
Self-citationSchiller, R. M., & Tibboel, D. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00494 · Cited by 18 · see citing works
Ma, S., Li, Y., Liu, Y., Xu, C., Li, H., Yao, Q., Wang, Y., Yang, Z., Zuo, P., Yang, M., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00691 · Cited by 14 · see citing works
“Fortunately, with advances in neuroimaging technology, brain injuries in children with CHDs are frequently identified early by magnetic resonance imaging (MRI) (27, 28); these brain injuries include delayed cerebral maturation (29), brain volume decline (30), white matter injury (WMI) (31), and stroke (32).”
BackgroundThe Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care
Ortinau, C. M., & Shimony, J. S. (2020) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2020.01.002 · Cited by 17 · see citing works
Onset of brain injury in infants with prenatally diagnosed congenital heart disease
Mebius, M. J., Bilardo, C. M., Kneyber, M. C. J., Modestini, M., Ebels, T., Berger, R. M. F., Bos, A. F., & Kooi, E. M. W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230414 · Cited by 17 · see citing works
Ehrler, M., Naef, N., Tuura, R., & Latal, B. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-032363 · Cited by 15 · see citing works
Self-citationNeuropathology of Congenital Heart Disease in an Inpatient Autopsy Cohort 2000–2017
Rettenmaier, L. A., Kirby, P., Reinking, B. E., Viaene, A. N., & Hefti, M. M. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.013575 · Cited by 14 · see citing works
Pérez‐Cruz, M., Gómez, O., Gibert, M., Masoller, N., Marimon, E., Lip‐Sosa, D. L., Bennasar, M., Bonet-Carné, E., Gómez‐Roig, M. D., Martínez-Crespo, J. M., et al. (2021) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23684 · Cited by 13 · see citing works
Juergensen, S., Liu, J., Xu, D., Zhao, Y., Moon‐Grady, A. J., Glenn, O. A., McQuillen, P. S., & Peyvandi, S. (2023) · Prenatal Diagnosis · doi:10.1002/pd.6450 · Cited by 14 · see citing works
Dijkhuizen, E. I., de Munck, S., de Jonge, R. C. J., Dulfer, K., van Beynum, I. M., Hunfeld, M., Rietman, A. B., Joosten, K. F. M., & van Haren, N. E. M. (2023) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15588 · Cited by 10 · see citing works
Loo, L. V., Cools, B., Dereymaeker, A., & Jansen, K. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1502762 · Cited by 11 · see citing works
DWI in Brains of Fetuses with Congenital Heart Disease: A Case-Control MR Imaging Study
Ren, J., Ji, H., Zhu, M., & Dong, S. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7267 · Cited by 10 · see citing works
Knirsch, W., Heye, K., Tuura, R., Hahn, A., Wetterling, K., Latal, B., Schranz, D., & Reich, B. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.03.055 · Cited by 8 · see citing works
Self-citationFourdain, S., Provost, S., Tremblay, J., Vannasing, P., Doussau, A., Caron-Desrochers, L., Gaudet, I., Roger, K., Hüsser, A. M., Dehaes, M., et al. (2023) · Child Neuropsychology · doi:10.1080/09297049.2023.2170340 · Cited by 9 · see citing works
Koning, I. V., van Graafeiland, A. W., Groenenberg, I. A. L., Husen, S. C., Go, A. T. J. I., Dudink, J., Willemsen, S. P., Cornette, J. M. J., & Steegers‐Theunissen, R. P. M. (2017) · Prenatal Diagnosis · doi:10.1002/pd.5135 · Cited by 10 · see citing works
Postnatal Brain Trajectories and Maternal Intelligence Predict Childhood Outcomes in Complex CHD
Lee, V., Ceschin, R. C., Reynolds, W. T., Meyers, B., Wallace, J., Landsittel, D. P., Joseph, H. M., Badaly, D., Gaynor, J. W., Licht, D. J., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102922 · Cited by 7 · see citing works
Steger, C., Feldmann, M., Borns, J., Hagmann, C. F., Latal, B., Held, U., András, J., Tuura, R., & Knirsch, W. (2022) · Pediatric Research · doi:10.1038/s41390-022-02253-y · Cited by 8 · see citing works
Self-citationProfiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Fan, X.-R., He, Y., Wang, Y.-S., Li, L., Adamson, C. L., Adler, S., Alexander‐Bloch, A. F., Anagnostou, E. A., Anderson, K. M., Areces-González, A., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08573-z · Cited by 9 · see citing works
Sajid, A., Chavez‐Valdez, R., Sharp, A. N., & Shah, D. K. (2025) · Pediatric Research · doi:10.1038/s41390-025-04360-y · Cited by 8 · see citing works
Asschenfeldt, B., Evald, L., Salvig, C. D., Heiberg, J., Østergaard, L., Eskildsen, S. F., & Hjortdal, V. E. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.020915 · Cited by 7 · see citing works
Chan, F., Bellsham‐Revell, H., Duggan, H., Simpson, J. M., Hulse, T., & Bell, A. (2016) · Cardiology in the Young · doi:10.1017/s104795111600024x · Cited by 7 · see citing works
Ehrler, M., von Rhein, M., Schlosser, L., Brugger, P., Greutmann, M., Kretschmar, O., Latal, B., & Tuura, R. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102885 · Cited by 7 · see citing works
Self-citationBonthrone, A. F., Chew, A. T. M., Bhroin, M. N., Morassutti, F. R., Kelly, C. J., Christiaens, D., Pietsch, M., Tournier, J., Cordero‐Grande, L., Price, A. N., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103153 · Cited by 6 · see citing works
Pfitzer, C., Sievers, L. K., Hütter, A., Khaliq, H. A., Poryo, M., Berger, F. F., Bauer, U. M. M., Helm, P., & Schmitt, K. R. L. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.917507 · Cited by 5 · see citing works
Neurodevelopmental outcomes in congenital heart disease: modifiable and nonmodifiable substrates
Wolfe, K. R., & Peyvandi, S. (2025) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001218 · Cited by 5 · see citing works
SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability
O’Brien, M. P., Pryzhkova, M. V., Lake, E. M. R., Mandino, F., Shen, X., Karnik, R., Atkins, A., Xu, M. J., Ji, W., Konstantino, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010430 · Cited by 5 · see citing works
Chao, B. K., Claessens, N. H. P., Lim, J. M., Gorodetsky, C., Au‐Young, S. H., Guerguerian, A., Marini, D., Blasér, S., Shroff, M. M., Saini, A., et al. (2020) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002336 · Cited by 5 · see citing works
Palmis, S., Easson, K., Devenyi, G. A., Gilbert, G., Saint‐Martin, C., Chakravarty, M. M., & Brossard‐Racine, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-94584-z · Cited by 4 · see citing works
Boutalbi, N., Dahan, S., Rozalen, W., Beretti, T., Fortis, L., Delefosse, L., Cloarec, R., Testud, B., Fouilloux, V., Gran, C., et al. (2025) · Pediatric Research · doi:10.1038/s41390-025-04437-8 · Cited by 4 · see citing works
Steger, C., Boegeholz, A., Latal, B., Feldmann, M., Kottke, R., Hagmann, C. F., Restin, T., Tuura, R., András, J., Reinehr, M. D., et al. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1556289 · Cited by 4 · see citing works
Self-citationVolpe, J. J. (2022) · Journal of Neonatal-Perinatal Medicine · doi:10.3233/npm-210942 · Cited by 5 · see citing works
Roberts, S. D., Sananes, R., Wojtowicz, M. A., Seed, M., Miller, S. P., Chau, V., Au‐Young, S. H., Guo, T., Ly, L. G., Kazazian, V., et al. (2024) · Cardiology in the Young · doi:10.1017/s1047951123004316 · Cited by 4 · see citing works
Wilson, S., Gal-Er, B., Cromb, D., Bonthrone, A. F., Chew, A., Pushparajah, K., Simpson, J. M., Falconer, S., Hajnal, J. V., Arichi, T., et al. (2025) · Imaging Neuroscience · doi:10.1162/imag.a.1063 · Cited by 4 · see citing works
Wen, X., Xue, P., Zhu, M., Zhong, J., Yu, W., Ma, S., Liu, Y., Liu, P., Jing, B., Yang, M., et al. (2025) · Human Brain Mapping · doi:10.1002/hbm.70155 · Cited by 3 · see citing works
Ceschin, R. C., Zahner, A., Reynolds, W., Beluk, N., & Panigrahy, A. (2022) · Diagnostics · doi:10.3390/diagnostics12071644 · Cited by 3 · see citing works
Machine learning for automatic segmentation of neonatal and fetal MR brain images
Khalili, N. (2020) · doi:10.33540/230 · Cited by 3 · see citing works
Ji, H., Wu, Z., Speckert, A., Tuura, R., Hagmann, C. F., Latal, B., Knirsch, W., & András, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.27.608544 · Cited by 3 · see citing works
Self-citationSun, Y. K., Liu, Y., Yu, W., & Zhong, Y. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.803006 · Cited by 2 · see citing works
Hippocampal morphometry is altered in infants with congenital heart disease
Gal-Er, B., Bonthrone, A. F., Nichols, E. S., Chew, A. T. M., Cromb, D., Casella, C., Egloff, A. M., Pushparajah, K., Simpson, J. M., Rutherford, M., et al. (2026) · Brain Communications · doi:10.1093/braincomms/fcag060 · Cited by 2 · see citing works
A low incidence of preoperative neurosonographic abnormalities in neonates with heart defects
Jansen, F. A. R., Haak, M. C., van Wesemael, M. S., ten Harkel, A. D. J., Lith, J. M. M. V., Blom, N. A., & Steggerda, S. J. (2020) · Early Human Development · doi:10.1016/j.earlhumdev.2020.105097 · Cited by 2 · see citing works
Long-Term Neurologic Outcomes in Children With Congenital Heart Disease
Peyvandi, S., & McQuillen, P. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-82823-9.00051-9 · Cited by 2 · see citing works
Lauridsen, M. H., Uldbjerg, N., Peters, D. A., Ringgaard, S., & Hjortdal, V. E. (2023) · Global Pediatrics · doi:10.1016/j.gpeds.2023.100052 · Cited by 2 · see citing works
Lee, V., Wallace, J., Meyers, B., Racki, A., Shah, A., Beluk, N., Cabral, L. M., Beers, S. R., Badaly, D., Lo, C. W. Y., et al. (2023) · medRxiv · doi:10.1101/2023.10.16.23297055 · Cited by 2 · see citing works
Semmel, E. S., Dawkins-Henry, O. S., Bernstein, J. H., Wypij, D., Calderon, J., Bellinger, D. C., Newburger, J. W., Gurvitz, M. Z., & Cassidy, A. R. (2024) · The Clinical Neuropsychologist · doi:10.1080/13854046.2024.2442424 · Cited by 1 · see citing works
- Authors
- von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., Dave, H., Prêtre, R., Hagmann, C., Knirsch, W., Kretschmar, O., Kellenberger, C., Scheer, I., Latal, B., Liamlahi, R., von Rhein, M., Plecko, B. R., & Sennhauser, F. H.
- Affiliations
- University Hospital Zurich (CH)
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 167
- Issue
- 6
- Pages
- 1259-1263.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1601921345
- Cited by
- 128
- References
- 29
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Else Kröner-Fresenius-Stiftung
- Schweizerische Herzstiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PMPDP3_129104)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- congenital heart disease, brain volumetry, fetal brain development, open heart surgery
- MeSH terms
- Brain, Developmental Disabilities, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Prospective Studies, Switzerland, Cohort Studies
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