The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
Open accessAbstract
Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).Conclusions Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, in the postnatal period (before surgery), a reduction of 20 per cent in cerebellar volume in neonates with SVP and TGA (n=19) has been observed.34”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In the citing paper
“In neonatal studies, white matter and CGM are comparably reduced in TGA and SVP.34,39”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In the citing paper
“In addition, the basal ganglia and thalami are smaller in SVP and TGA when compared with healthy controls, in both the fetal 38 and neonatal 34 period.”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
Citations
Cites
Abnormal brain development in newborns with congenital heart disease
Miller, S. P., McQuillen, P. S., Hamrick, S., Xu, D., Glidden, D. V., Charlton, N., Karl, T., Azakie, A., Ferriero, D. M., Barkovich, A. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067393 · Cited by 860
Bellinger, D. C., Wypij, D., duPlessis, A. J., Rappaport, L. A., Jonas, R. A., Wernovsky, G., & Newburger, J. W. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00711-6 · Cited by 681
Limperopoulos, C., Tworetzky, W., McElhinney, D. B., Newburger, J. W., Brown, D. W., Robertson, R. L., Guizard, N., McGrath, E., Geva, J., Annese, D., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.865568 · Cited by 663
Brain maturation is delayed in infants with complex congenital heart defects
Licht, D. J., Shera, D. M., Clancy, R. R., Wernovsky, G., Montenegro, L. M., Nicolson, S. C., Zimmerman, R. A., Spray, T. L., Gaynor, J. W., & Vossough, A. (2009) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.10.025 · Cited by 629
An MRI Study of Neurological Injury Before and After Congenital Heart Surgery
Mahle, W. T., Tavani, F., Zimmerman, R. A., Nicolson, S. C., Galli, K. K., Gaynor, J. W., Clancy, R. R., Montenegro, L. M., Spray, T. L., Chiavacci, R. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000032908.33237.b1 · Cited by 541
Sun, L., Macgowan, C. K., Sled, J. G., Yoo, S.-J., Manlhiot, C., Porayette, P., Grosse-Wortmann, L., Jaeggi, E., McCrindle, B. W., Kingdom, J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013051 · Cited by 533
Bellinger, D. C., Wypij, D., Rivkin, M. J., DeMaso, D. R., Robertson, R. L., Dunbar-Masterson, C., Rappaport, L. A., Wernovsky, G., Jonas, R. A., & Newburger, J. W. (2011) · Circulation · doi:10.1161/circulationaha.111.026963 · Cited by 476
Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects
McQuillen, P. S., Barkovich, A. J., Hamrick, S. E. G., Perez, M., Ward, P., Glidden, D. V., Azakie, A., Karl, T., & Miller, S. P. (2007) · Stroke · doi:10.1161/01.str.0000247941.41234.90 · Cited by 379
Delayed cortical development in fetuses with complex congenital heart disease
Clouchoux, C., du Plessis, A. J., Bouyssi-Kobar, M., Tworetzky, W., McElhinney, D. B., Brown, D. W., Gholipour, A., Kudelski, D., Warfield, S. K., McCarter, R. J., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs281 · Cited by 309
Beca, J., Gunn, J. K., Coleman, L., Hope, A., Reed, P. W., Hunt, R. W., Finucane, K., Brizard, C., Dance, B., & Shekerdemian, L. S. (2013) · Circulation · doi:10.1161/circulationaha.112.001089 · Cited by 301
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–128 of 128
Sex effects on cortical alterations in infants with complex congenital heart disease
Wen, X., Xue, P., Ma, S., Zhu, M., Liu, Y., Liu, P., Jing, B., Ge, R., Yang, M., Mo, X., et al. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf339 · Cited by 1
Long-Term Neurologic Outcomes in Children With Congenital Heart Disease
Peyvandi, S., & McQuillen, P. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-40139-5.00057-7 · Cited by 1
Is routine preoperative head ultrasound screening before congenital cardiac surgery mandatory?
Farooq, S., Hassan, H. A., Alsasi, O., Alfawzan, T., Eltayeb, A., Mohamed, S., Rafique, S., Ali, G. M., Alanezi, T. J., Alharbi, A. H., et al. (2025) · The Cardiothoracic Surgeon · doi:10.1186/s43057-024-00143-z · Cited by 1
Anesthesia for Children Undergoing Heart Surgery
McEwan, A. I., & Rolo, V. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00017-3 · Cited by 2
A Little Sugar Never Hurt Anyone: Hyperglycemia after Infant Heart Surgery
Mahle, W. T. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.09.002 · Cited by 1
Glass, T. J. A., Seed, M., & Chau, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-54392-7.00015-7 · Cited by 1
Pediatric Neurovascular Conditions: Developmental and Neuropsychological Implications
Westmacott, R., & Baron, I. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-49586-2_16
Linking congenital heart disease and brain functional connectivity in newborns
Asis‐Cruz, J. D., & Limperopoulos, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817988-8.00024-5
Brain growth in congenital heart disease from prenatal environment to adulthood
Ortinau, C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817988-8.00025-7
Preoperative Diagnostic Evaluation
Deal, B. J., Hauck, A. L., Tsao, S. S. L., Patel, A., Lee, S., & McElhinney, D. B. (2023) · Wiley eBooks · doi:10.1002/9781119282327.ch4
Lee, V. K., Ceschin, R. C., Reynolds, W. T., Meyers, B., Wallace, J., Landsittel, D. P., Joseph, H. M., Badaly, D., Gaynor, J. W., Licht, D. J., et al. (2023) · medRxiv · doi:10.1101/2023.10.11.23296856
Hu, L., Wu, K., Li, H., Zhu, M., Zhang, Y., Fu, M., Tang, M., Lu, F., Cai, X., An, J., et al. (2024) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-024-01764-0
Reynolds, W. T., Votava‐Smith, J. K., Gabriel, G. C., Lee, V., Rajagopalan, V., Wu, Y. L., Liu, X., Yagi, H., Slabicki, R., Gibbs, B., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195772
Aguirre-Martínez, M. A., Bautista, L. F. C., Hernández-Carrillo, M., & Montero, A. F. S. (2024) · Birth Defects Research · doi:10.1002/bdr2.2402
Maternal and Fetal Conditions With Consequences for the Fetal Brain
du Plessis, A. J., & Volpe, J. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-10513-5.00011-5
Born too young or too blue tips the scaling of a folded brain
McQuillen, P. S., & Harasymiw, L. A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2506954122
Cardiovascular Hemodynamics and Brain Health in Congenital Heart Disease
Hogan, W. J., & Peyvandi, S. (2025) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2025.05.008
Cortical surface area drives volumetric and cognitive deficits in complex congenital heart diseasePreprint
Toyofuku, A., Ehrler, M., Kretschmar, O., Latal, B., & Tuura, R. (2025) · medRxiv · doi:10.1101/2025.10.09.25337644
Self-citationDeRose, L., Martin, M. M., George, E., Silva, K. L., Gallegos, F. N., Steurer, M. A., Xu, D., McQuillen, P. S., & Peyvandi, S. (2026) · Pediatric Cardiology · doi:10.1007/s00246-026-04308-x
Intrathalamic morphometry in infants with congenital heart disease and infants born pretermPreprint
Clayden, B., Gal-Er, B., van der Meijden, M. E. M., Cromb, D., Wilson, S., Pushparajah, K., Simpson, J. M., Kelly, C. J., Chew, A. T. M., Hajnal, J. V., et al. (2026) · medRxiv · doi:10.64898/2026.03.16.26348485
Cortical morphology and cognitive impairments in adolescents with complex congenital heart disease
Toyofuku, A., Ehrler, M., Kretschmar, O., Latal, B., & Tuura, R. (2026) · Brain Communications · doi:10.1093/braincomms/fcag124
Self-citationHofmann, M., Schmiady, M., Schulte, D., Aigner, T., Bektas, R. N., Wieser, M., Lentini, M., Chicca, F. D., Loeschmann, C., Hübler, M., et al. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13050182
Dagur, G., Ortinau, C. M., Chin, T. I., Morris, G., Kleinmahon, J. A., Gurvitz, M. Z., & Bora, S. (2026) · PEDIATRICS · doi:10.1542/peds.2025-071101
Gal-Er, B., Bonthrone, A. F., Chew, A. T. M., Wilson, S., Cromb, D., Egloff, A. M., Pushparajah, K., Simpson, J. M., van der Meijden, M. E. M., Rutherford, M., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-55283-5
Brain volumes in congenital heart disease from childhood to adulthood: A pooled neuroimaging study
Toyofuku, A., Naef, N., Rousson, V., Ehrler, M., Wehrle, F. M., Schlosser, L., von Rhein, M., Liamlahi, R., Greutmann, M., Kretschmar, O., et al. (2026) · Neuroimage Reports · doi:10.1016/j.ynirp.2026.100379
Self-citationFetal MRI Reveals Altered Subplate Development in Congenital Heart DiseasePreprint
Gondová, A., Jeong, S., Stepovich, N., Tworetzky, W., Bradford, V. R., Sadhwani, A., Zhang, J., You, S., Grant, P. E., Im, K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.18.745587
Dogan, Y. E., Vargas-Boggiano, D., Bleiweis, M. S., Philip, J., Narasimhulu, S. S., Tuna, İ. S., & Weiss, M. D. (2026) · Pediatric Research · doi:10.1038/s41390-026-05454-x
Metadata
- Authors
- von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., Dave, H., Prêtre, R., Hagmann, C., Knirsch, W., Kretschmar, O., Kellenberger, C., Scheer, I., Latal, B., Liamlahi, R., von Rhein, M., Plecko, B. R., & Sennhauser, F. H.
- Affiliations
- University Hospital Zurich (CH)
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 167
- Issue
- 6
- Pages
- 1259-1263.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1601921345
- Cited by
- 128
- References
- 29
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Else Kröner-Fresenius-Stiftung
- Schweizerische Herzstiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PMPDP3_129104)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- congenital heart disease, brain volumetry, fetal brain development, open heart surgery
- MeSH terms
- Brain, Developmental Disabilities, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Prospective Studies, Switzerland, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
