Systematic review and meta-analysis: fussing and crying durations and prevalence of colic in infants
Open accessAbstract
Objective To determine the mean duration of fussing and crying and prevalence of colic using modified Wessel criteria in infants in the first 3 months of life.Study design A systematic literature search was performed using the databases Medline, PsycINFO, and Embase. The major outcome measure was mean total fuss/cry duration during 24 hours at ages 1-2 weeks (11 samples), 3-4 weeks (6 samples), 5-6 weeks (28 samples), 8-9 weeks (9 samples), and 10-12 weeks (12 samples).Results Of 5687 articles reviewed, 28 diary studies (33 samples) were suitable for inclusion in meta-analysis; these studies included 8690 infants. No statistical evidence for a universal crying peak at 6 weeks of age across studies was found. Rather, the mean fuss/cry duration across studies was stable at 117-133 minutes (SDs: 66-70) in the first 6 weeks and dropped to a mean of 68 minutes (SD: 46.2) by 10-12 weeks of age. Colic was much more frequent in the first 6 weeks (17%-25%) compared with 11% by 8-9 weeks of age and 0.6% by 10-12 weeks of age, according to modified Wessel criteria and lowest in Denmark and Japan.Conclusions The duration of fussing/crying drops significantly after 8-9 weeks of age, with colic as defined by modified Wessel criteria being rare in infants older than 9 weeks. Colic or excessive fuss/cry may be more accurately identified by defining fuss/cry above the 90th percentile in the chart provided based on the review.
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By 6 weeks of age, as many as one quarter of infants show infant colic.
“Infant colic, a characteristic group of behaviors featuring prolonged crying, is present in up to 25% of infants at 6 weeks of life173”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [173]
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- Authors
- Wolke, D., Bilgin, A., & Samara, M.
- Affiliations
- University of Warwick (GB)
- Kingston University London (GB)
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 185
- Pages
- 55-61.e4
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2604359107
- Cited by
- 255
- References
- 89
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 32 · 2023: 23 · 2022: 35 · 2021: 43 · 2020: 36 · 2019: 17 · 2018: 20 · 2017: 6
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Research Repository (Kingston University London) (acceptedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Funders
- University of Warwick
- Topics
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- infantile colic, infant crying, crying duration
- MeSH terms
- Colic, Crying, Humans, Infant, Infant, Newborn, Irritable Mood, Time Factors, Prevalence, Infant Behavior
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