CoChat
Sign Up
Cited by 26Viral Infections and Immunology ResearchInfectious Encephalopathies and EncephalitisNeonatal and Maternal Infections

Impact of Enteroviral Polymerase Chain Reaction Testing on Length of Stay for Infants 60 Days Old or Younger

Open access
Aronson, Paul L., Lyons, Todd W., Cruz, Andrea T., Freedman, Stephen B., Okada, Pamela J., Fleming, Alesia H., Arms, Joseph L., Thompson, Amy D. +21 more·2017·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2017.06.021PMC PMC5870831
Open this paper in CoChat — free account

Abstract

Objective To determine the impact of a cerebrospinal fluid enterovirus polymerase chain reaction (PCR) test performance on hospital length of stay (LOS) in a large multicenter cohort of infants undergoing evaluation for central nervous system infection.Study design We performed a planned secondary analysis of a retrospective cohort of hospitalized infants ≤60 days of age who had a cerebrospinal fluid culture obtained at 1 of 18 participating centers (2005-2013). After adjustment for patient age and study year as well as clustering by hospital center, we compared LOS for infants who had an enterovirus PCR test performed vs not performed and among those tested, for infants with a positive vs negative test result.Results Of 19 953 hospitalized infants, 4444 (22.3%) had an enterovirus PCR test performed and 945 (21.3% of tested infants) had positive test results. Hospital LOS was similar for infants who had an enterovirus PCR test performed compared with infants who did not (incident rate ratio 0.98 hours; 95% CI 0.89-1.06). However, infants PCR positive for enterovirus had a 38% shorter LOS than infants PCR negative for enterovirus (incident rate ratio 0.62 hours; 95% CI 0.57-0.68). No infant with a positive enterovirus PCR test had bacterial meningitis (0%; 95% CI 0-0.4).Conclusions Although enterovirus PCR testing was not associated with a reduction in LOS, infants with a positive enterovirus PCR test had a one-third shorter LOS compared with infants with a negative enterovirus PCR test. Focused enterovirus PCR test use could increase the impact on LOS for infants undergoing cerebrospinal fluid evaluation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jpeds.2017.06.021

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • It has been shown in a number of studies that rapid detection of EV can decrease unnecessary antimicrobials, length of hospital stay, and hospital costs.

    “it has been shown in a number of studies that rapid detection of EV can decrease unnecessary antimicrobials, length of hospital stay, and hospital costs (5, 7, 20).”

    From Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel (2018) · cites this paper as [5]

    The paper’s introduction reports that positive EV PCR results have been associated with shorter hospital stays and less time on parenteral antibiotics. Its Results and Conclusions find shorter stays for infants with positive results, but no reduction in length of stay from testing overall. The Discussion describes lower healthcare costs as a conditional projection from a prior cost analysis, not an observed result of this study. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 30 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Aronson, P. L., Lyons, T. W., Cruz, A. T., Freedman, S. B., Okada, P. J., Fleming, A. H., Arms, J. L., Thompson, A. D., Schmidt, S. M., Louie, J., Alfonzo, M. J., Monuteaux, M. C., Nigrovic, L. E., Alpern, E. R., Balamuth, F., Bradin, S. A., Curtis, S. J., Garro, A. C., Grether-Jones, K. L., Ishimine, P. T., Kulik, D., Mahajan, P., Miller, A. S., Mistry, R. D., Pruitt, C. M., Schnadower, D., Shah, S. S., Thomson, J. E., & Uspal, N. G.
Affiliations
  • Yale University (US)
  • Boston Children's Hospital (US)
  • Baylor College of Medicine (US)
  • University of Calgary (CA)
  • The University of Texas Southwestern Medical Center (US)
  • Emory University (US)
  • Children's Minnesota (US)
  • Alfred I. duPont Hospital for Children (US)
  • Northwestern University (US)
  • University of Minnesota (US)
  • NewYork–Presbyterian Hospital (US)
Corresponding author
Nigrovic, Lise E.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2017-10
Volume
189
Pages
169-174.e2
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2017.06.021
PMC
PMC5870831
OpenAlex
W2735947021
Cited by
26
References
30
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 5
FWCI
3.38
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Section of Emergency Medicine
  • Baylor College of Medicine
  • CTSA) (KL2 TR001862)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH) Childhood (5T32HD040128-12)
  • Alberta Children's Hospital Foundation Professorship in Child Health and Wellness
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
enterovirus, PCR testing, cerebrospinal fluid, length of hospital stay, infants, central nervous system infection, bacterial meningitis, pediatric neurology
MeSH terms
Cerebrospinal Fluid, Enterovirus Infections, Enterovirus, Female, Humans, Infant, Length of Stay, Male, Meningitis, Viral, Retrospective Studies, Cohort Studies, Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review