CoChat
Sign Up
Cited by 126Viral Infections and Immunology ResearchLiterature Analysis and CriticismNeonatal and Maternal Infections

Diagnosis and Outcomes of Enterovirus Infections in Young Infants

Rittichier, Kristine R., Bryan, Paul A., Bassett, Kathlene E., Taggart, E William, Enriquez, F Rene, Hillyard, David R., Byington, Carrie L.·2005·Pediatric Infectious Disease Journal
DOI 10.1097/01.inf.0000164810.60080.ad
Open this paper in CoChat — free account

Abstract

BACKGROUND: Enterovirus (EV) infections commonly cause fever in infants younger than 90 days of age. The polymerase chain reaction (PCR) has improved our ability to diagnose EV infections. OBJECTIVE: To evaluate the utility of blood and cerebrospinal fluid (CSF) specimens for the diagnosis of EV infections by PCR and to describe a large cohort of EV-infected infants. DESIGN/METHODS: Febrile infants younger than 90 days of age evaluated for sepsis at Primary Children's Medical Center in Salt Lake City, UT, were enrolled in a prospective study designed to identify viral infections from December 1996 to June 2002. All patients had bacterial cultures of blood, urine and CSF. Testing for EV was performed by PCR and/or viral cultures. Patients who were positive for EV were identified for this study. RESULTS: Of 1779 febrile infants enrolled, 1061 had EV testing and 214 (20%) were EV-positive. EV infections were diagnosed by PCR of blood, CSF or both in 93% of infants. PCR testing was positive in blood in 57%, and blood was the only positive specimen for 22% of EV infected infants. PCR of CSF was positive in 74%. The mean age of infants with EV infection was 33 days, with 18% younger than 14 days and 5% younger than 7 days. Fifty percent of EV-positive infants had CSF pleocytosis. Of EV PCR-positive infants, 91% were admitted, and 2% required intensive care. Possible serious EV disease was diagnosed in <1%, and there were no deaths. Twelve infants (5.6%) had concomitant urinary tract infection, and 3 (1%) had bacteremia. CONCLUSIONS: EV infections are common in febrile infants younger than 90 days. Blood and CSF are equally likely to yield positive results by PCR, but the combination of both specimens improved the diagnostic yield.

Integrity signals

Registry

Crossref · 10.1097/01.inf.0000164810.60080.ad

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Rittichier, K. R., Bryan, P. A., Bassett, K. E., Taggart, E. W., Enriquez, F. R., Hillyard, D. R., & Byington, C. L.
Affiliations
  • University of Utah (US)
  • Houston Methodist (US)
Corresponding author
  • Bryan, Paul A.
  • Bassett, Kathlene E.
ORCID
Byington, Carrie L.
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-06
Volume
24
Issue
6
Pages
546-550
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/01.inf.0000164810.60080.ad
OpenAlex
W1987546663
Cited by
126
References
49
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 10 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 7
FWCI
4.79
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (M01RR000064)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
enterovirus infection, febrile infants, infants under 90 days, PCR diagnosis, cerebrospinal fluid, blood samples, cerebrospinal fluid pleocytosis, urinary tract infection, bacteremia, sepsis, intensive care unit admission
MeSH terms
Blood, Cerebrospinal Fluid, Enterovirus Infections, Enterovirus, Fever, Humans, Infant, Infant, Newborn, Viremia, Virus Cultivation, Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review